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Molecules, Vol. 23, Pages 719: Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3 β Inhibitors
Molecules, Vol. 23, Pages 719: Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors Molecules doi: 10.3390/molecules23040719 Authors: Daniela Hulcová Kateřina Breiterová Tomáš Siatka Kamila Klímová Lara Davani Marcela Šafratová Anna Hošťálková Angela De Simone Vincenza Andrisano Lucie Cahlíková Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism. It plays a key role in diverse physiological processes including metabolism, the cel...
Source: Molecules - March 21, 2018 Category: Chemistry Authors: Daniela Hulcov á Kate řina Breiterová Tom áš Siatka Kamila Kl ímová Lara Davani Marcela Šafratová Anna Ho šťálková Angela De Simone Vincenza Andrisano Lucie Cahl íková Tags: Article Source Type: research

Let us Break the Heart Attack Related Myths in Women on the Eve of International Women ’s Day
Several myths surrounding heart diseases state that heart diseases attract only elder people and more men than women are prone to heart attacks. Contrary to the belief, cardiovascular cases are on rise in women than men and it is deadlier than all forms of cancers combined. Both physiological and psychological factors are causing heart diseases and it affects people of all ages with no bias. Women that have suffered from mental illness are more susceptible to attract heart risks like stroke. Mental ill health like schizophrenia, anxiety disorders and bipolar disorders are mostly treated with antidepressants, antipsychotics...
Source: Sciences Blog - March 9, 2018 Category: Science Authors: srinivas_s at omicsgroup.co.in (OMICS Publishing Group) Tags: OMICS Anxiety Disorders bipolar disorders cardiovascular cases heart attacks heart diseases psychological factors Source Type: blogs

Comorbid Psychiatric Disease Is Associated With Lower Rates of Thrombolysis in Ischemic Stroke Brief Report
Background and Purpose—Intravenous thrombolysis (IVT) improves outcomes after acute ischemic stroke but is underused in certain patient populations. Mental illness is pervasive in the United States, and patients with comorbid psychiatric disease experience inequities in treatment for a range of conditions. We aimed to determine whether comorbid psychiatric disease is associated with differences in IVT use in acute ischemic stroke.Methods—Acute ischemic stroke admissions between 2007 and 2011 were identified in the Nationwide Inpatient Sample. Psychiatric disease was defined by International Classification of Diseases, ...
Source: Stroke - February 26, 2018 Category: Neurology Authors: Diana M. Bongiorno, Gail L. Daumit, Rebecca F. Gottesman, Roland Faigle Tags: Quality and Outcomes, Ischemic Stroke Brief Reports Source Type: research

Wants Talk Psychotherapy but Cannot Talk: EMDR for Post-stroke Depression with Expressive Aphasia
CONCLUSION This is the first reported case demonstrating that EMDR can be effective for depression, even in those with severe expressive aphasia. In our case, there was no reluctance to disclose information, simply a neurological inability to do so. Through preparation, patience, perseverance, and plasticity (clinician flexibility, though perhaps also neuroplasticity), the patient’s PSD gradually improved, and she was able to reinvent her life within her limitations. ACKNOWLEDGMENTS The authors gratefully acknowledge Eugene Schwartz, E.C. Hurley, and Mark Hubner for providing consultation during patient care. REFERENCES ...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Neurologic Systems and Symptoms Neurology Psychotherapy Stroke aphasia depression EMDR Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Psychotropic Use and Risk of Stroke among Patients with Bipolar Disorders: 10-Year Nationwide Population Based Study
To investigate the association between psychotropic agents (including antipsychotics, antidepressants and mood stabilizers) and risk of stroke among patients with bipolar disorders.
Source: Journal of Affective Disorders - September 21, 2017 Category: Neurology Authors: Chi-Shin Wu, Kuan-Yi Wu, Yu-Ru Lo, Ya-Wen Huang, Yu-Ting Tsai, Yashiun Li, Hui-Ju Tsai Tags: Research paper Source Type: research

Associations between illness duration and health-related quality of life in specified mental and physical chronic health conditions: results from a population-based survey
ConclusionsLoss of HRQOL associated with longer  duration of chronic illness is most apparent in stroke and mental illness and differs between age groups.
Source: Quality of Life Research - September 13, 2017 Category: Health Management Source Type: research

The risk of initiating fluoxetine for motor deficits after ischemic stroke in patients with bipolar disorder
Discussion Ayahuasca administration in controlled settings appear to be safe. Moreover, ayahuasca seem to have therapeutic effects for treatment-resistant psychiatric disorders that should be further investigated in randomized controlled clinical trials. However, medical complications and cases of prolonged psychotic reactions have been reported, and people with personal or family history of psychotic disorders should avoid ayahuasca intake.
Source: Revista de Psiquiatria Clinica - August 31, 2017 Category: Psychiatry Source Type: research

Surgical Treatment of Atrial Fibrillation in Patients with Rheumatic Valve Disease
Conclusion: Atrial fibrillation ablation surgery with surgical approach of rheumatic mitral valve resulted in 63.1% patients in sinus rhythm after one year. Discharge from hospital in sinus rhythm was a predictor of maintenance of this rhythm. Increased left atrium and use of unipolar radiofrequency were associated with lower chance of sinus rhythm. Operative mortality rate of 7.7% and survival and stroke-free survival contribute to excellent care results for this approach.
Source: Revista Brasileira de Cirurgia Cardiovascular - August 17, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

May 2010
Major Ups and Downs : Bipolar Disorder Brings Extreme Mood Swings Strike Out Stroke : Quick Action Can Keep Damage at Bay Extra Vitamin C& E Don ’t Reduce Pregnancy Blood Pressure Risks Diabetes and Risk for Heart Disease and Stroke Advances in Medical Imaging
Source: NIH News in Health - August 15, 2017 Category: Consumer Health News Source Type: news

Surgical Treatment of Atrial Fibrillation in Patients with Rheumatic Valve Disease
Objective: To assess heart rhythm and predictive factors associated with sinus rhythm after one year in patients with rheumatic valve disease undergoing concomitant surgical treatment of atrial fibrillation. Operative mortality, survival and occurrence of stroke after one year were also evaluated.Methods: Retrospective longitudinal observational study of 103 patients undergoing rheumatic mitral valve surgery and ablation of atrial fibrillation using uni- or bipolar radiofrequency between January 2013 and December 2014. Age, gender, functional class (NYHA), type of atrial fibrillati...
Source: Brazilian Journal of Cardiovascular Surgery - August 14, 2017 Category: Cardiology Source Type: research

For Humanitarian Workers, Mental Health Needs Are Often Overlooked
July 19, 2017It ' s time to take mental well-being during complex emergencies seriously.In my family there was always a strong culture of suffering in silence. We were encouraged as children to ignore small injuries and illnesses, and to soldier on without complaint.I only realized the full extent of this embedded behavior when my elderly mother dislocated her shoulder and refused to go to the hospital for 24 hours, somehow believing that it would get better on its own.It has always been difficult to shake off this deeply ingrained sense that to ask for help is somehow weak. When, in a one year period, my son had a serious...
Source: IntraHealth International - July 19, 2017 Category: International Medicine & Public Health Authors: mnathe Source Type: news

Does Surgical Ablation Energy Source Affect Long-Term Success of the Concomitant Cox Maze Procedure?
Conclusions Concomitant CM procedures performed with cryothermal energy alone or combined with bipolar radiofrequency ablation are safe and exceedingly effective. The association of cryothermal energy alone with higher rates of sinus rhythm and stroke reduction should be investigated further.
Source: The Annals of Thoracic Surgery - June 17, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Thoracoscopic radiofrequency ablation for lone atrial fibrillation: Box-lesion technique
Conclusion The thoracoscopic box-lesion ablation procedure is a safe, effective, and minimally invasive method for the treatment of isolated (lone) AF. This procedure provided excellent short-term freedom from AF.
Source: Cor et Vasa - June 14, 2017 Category: Cardiology Source Type: research

Overfed and Underfed: Global Food Extremes
The international community of nations has made commitments to eliminate hunger, achieve food security and improved nutrition by 2030 and also to promote and protect health through nutritious diet, healthy eating and increased physical activity. Credit: IPSBy Joseph ChamieNEW YORK, Jun 12 2017 (IPS)Global food extremes of chronic undernourishment and obesity have brought about a bipolar world of hundreds of millions of underfed and overfed people. Of the world’s population of 7.5 billion the proportions suffering from chronic undernourishment and those afflicted by obesity are similar, approximately 11 percent or togethe...
Source: IPS Inter Press Service - Health - June 12, 2017 Category: International Medicine & Public Health Authors: Joseph Chamie Tags: Development & Aid Food & Agriculture Global Headlines Health Poverty & SDGs Regional Categories Source Type: news