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Condition: Mania
Drug: Lithium

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Total 19 results found since Jan 2013.

Mood stabilisers and risk of stroke in bipolar disorder.
CONCLUSIONS: Use of carbamazepine and valproic acid, but not lithium and lamotrigine, is associated with increased risk of stroke in patients with bipolar disorder.Declaration of interestNone. PMID: 30295208 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - October 10, 2018 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

A reduced risk of stroke with lithium exposure in bipolar disorder: a population‐based retrospective cohort study
ConclusionsLithium use was significantly related to a reduced risk of stroke in patients with bipolar disorder.
Source: Bipolar Disorders - September 23, 2015 Category: Psychiatry Authors: Chen‐Chia Lan, Chia‐Chien Liu, Ching‐Heng Lin, Tzuo‐Yun Lan, Melvin G McInnis, Chin‐Hong Chan, Tsuo‐Hung Lan Tags: Original Article Source Type: research

Lithium intoxication in the pre-hospital care with stroke symptoms - Case report.
Authors: Peran D, Pukovcova K, Pekara J, Nesvadba M, Nedved V, Christian Cmorej P, Cmorej PC, Bohm P, Mamova A Abstract Lithium is widely used in psychiatry to treat bipolar affective disorders since 1970 but little is known about the incidence, clinical course and associated factors of acute lithium intoxication. Moderate and severe cases of lithium intoxication are rare. This case reports a patient with acute lithium intoxication (serum level of 3.7 mmol/L) with neurological symptoms imitating stroke, which affects the differential diagnosis in the pre-hospital and hospital care. Patient was treated with forced d...
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Phosphorylation of PI3K/Akt at Thr308, but not MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Exp Neurol. 2022 Feb 2:113996. doi: 10.1016/j.expneurol.2022.113996. Online ahead of print.ABSTRACTLithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its modulatory effect on GSK pathway. Therefore, we initially analyzed the dose-dependent effects of lithium on neurological deficits, infarct volume, brain edema and blood-brain barrier integrity, along with neuronal injury and survival in mice subjected to focal cerebral ischemia. Thereafter, we investigated the in...
Source: Experimental Neurology - February 5, 2022 Category: Neurology Authors: Nilay Ates Aysun Caglayan Zeynep Balcikanli Elif Sertel Mustafa Caglar Beker Pelin Dilsiz Ahmet Burak Caglayan S üleyman Celik Muhammed Furkan Dasdelen Berrak Caglayan T ürkan Yigitbasi Hanefi Ozbek Thorsten Roland Doeppner Dirk Matthias Hermann Ertugru Source Type: research

Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/ β-catenin signaling in mice.
Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/β-catenin signaling in mice. Neuropharmacology. 2021 Jan 29;:108474 Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Abstract Although upregulation of endothelial Wnt/β-catenin signaling may be used to treat blood-brain barrier (BBB) breakdown caused by cerebral ischemia/reperfusion injury, no agents based on this mechanism are available clinically. Lithium, a medication used for treating bipolar mood disorders, upregulates Wnt/β-...
Source: Neuropharmacology - January 29, 2021 Category: Drugs & Pharmacology Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Tags: Neuropharmacology Source Type: research

A differential impact of lithium on endothelium–dependent but not on endothelium–independent vessel relaxation
Publication date: Available online 10 February 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Bert Bosche, Marek Molcanyi, Thomas Noll, Soham Rej, Birgit Zatschler, Thorsten R. Doeppner, Jürgen Hescheler, Daniel J. Müller, R. Loch Macdonald, Frauke V. Härtel Lithium is drug for bipolar disorders with a narrow therapeutic window. Lithium was recently reported to prevent stroke and protect vascular endothelium but tends to accumulate particularly in the brain and kidney. Here, adverse effects are common; however mechanisms are still vaguely understood. If lithium could al...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 12, 2016 Category: Psychiatry Source Type: research

A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation
Publication date: 3 June 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 67 Author(s): Bert Bosche, Marek Molcanyi, Thomas Noll, Soham Rej, Birgit Zatschler, Thorsten R. Doeppner, Jürgen Hescheler, Daniel J. Müller, R. Loch Macdonald, Frauke V. Härtel Lithium is drug for bipolar disorders with a narrow therapeutic window. Lithium was recently reported to prevent stroke and protect vascular endothelium but tends to accumulate particularly in the brain and kidney. Here, adverse effects are common; however mechanisms are still vaguely understood. If lithium could also negative...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 17, 2016 Category: Psychiatry Source Type: research

Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature
AbstractThis was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2  weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and longest foll...
Source: The Cerebellum - June 8, 2017 Category: Neurology Source Type: research

Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature.
Abstract This was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2 weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and lon...
Source: Cerebellum - June 8, 2017 Category: Neuroscience Authors: Rossi FH, Rossi EM, Hoffmann M, Liu W, Cruz RR, Antonovich N, Rezaei A, Gonzalez E, Franco MC, Estevez A, Thomas F Tags: Cerebellum Source Type: research

The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3 β inhibition in intracerebral hemorrhage rats.
In this study, Male Sprague-Dawley rats, subjected to intrastriatal blood infusion, were treated with lithium chloride and underwent neurobehavioral test for equivalent injury severity and neurological functional deficits, Morris water maze test for cognitive impairment, high performance liquid chromatography analysis for excitotoxic index determination, immunohistochemistry analysis for neuronal apoptosis, and Western blot analysis for glycogen synthase kinase-3β activity. Our results showed lithium chloride inhibited glycogen synthase kinase-3β activation, which on one hand, suppressed downstream CRMP-2/NR2B, thus dimi...
Source: European Journal of Pharmacology - October 15, 2018 Category: Drugs & Pharmacology Authors: Liu Z, Li R, Jiang C, Zhao S, Li W, Tang X Tags: Eur J Pharmacol Source Type: research

Lithium intoxication presenting as altered consciousness and arrhythmia with cardiogenic shock: A case report
Rationale: Lithium has been used to treat bipolar disorder. Lithium has a narrow therapeutic index, with a therapeutic level between 0.6 and 1.5 mEq/L. The possible complications of lithium overdose include altered mental status, hand tremor, muscle weakness, nausea, vomiting, diarrhea, seizure, syncope, and arrhythmia. Lithium intoxication can be fatal and is difficult to diagnose in patients without a history of lithium intake. The occurrence of serious cardiac arrhythmias is rare in lithium intoxication. Patient concerns: An 81-year-old man was brought to the emergency department because of consciousness disturba...
Source: Medicine - November 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3 β inhibitors: A critical review.
Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review. Eur J Med Chem. 2018 Dec 31;164:448-470 Authors: Xu M, Wang SL, Zhu L, Wu PY, Dai WB, Rakesh KP Abstract Glycogen Synthase Kinase-3 (GSK-3) is a constitutively dynamic, omnipresent serine/threonine protein kinase regularly called as a "multitasking kinase" due to its pliable function in diverse signaling pathways. It exists in two isoforms i.e., GSK-3α and GSK-3β. Inhibition of GSK-3 may be useful in curing various diseases such as Alzheimer's disease, type II diabetes, mood disorde...
Source: European Journal of Medicinal Chemistry - December 31, 2018 Category: Chemistry Authors: Xu M, Wang SL, Zhu L, Wu PY, Dai WB, Rakesh KP Tags: Eur J Med Chem Source Type: research

Atorvastatin in the treatment of lithium-induced nephrogenic diabetes insipidus: the protocol of a randomized controlled trial
Lithium is the gold-standard treatment for bipolar disorder, is highly effective in major depressive disorder, and is being investigated for therapeutic benefits in dementia, stroke, and even cancer. Approximately 350,000 Canadians use lithium and more could benefit. Despite this, clinicians are avoiding lithium, largely due to fear of renal toxicity, including irreversible chronic kidney disease (CKD). Nephrogenic Diabetes Insipidus (NDI) occurs in 20% of lithium users and independently predicts a 2-3 times increased risk of CKD.
Source: The American Journal of Geriatric Psychiatry - February 28, 2019 Category: Geriatrics Authors: Jocelyn Fotso Soh, Gabriela Torres-Platas, Serge Beaulieu, Outi Mantere, Robert Platt, Istvan Mucsi, Sybille Saury, Suzane Renaud, Andrea Levinson, Ana Andreazza, Benoit Mulsant, Daniel Mueller, Ayal Schaffer, Annemiek Dols, Nancy Low, Pablo Cervantes, Na Tags: Poster Number: EI - 48 Source Type: research