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Condition: Huntington's Disease
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Total 289 results found since Jan 2013.
Molecules, Vol. 27, Pages 6804: Alzheimer & rsquo;s Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms
This study highlights various neuroprotective mechanisms of saponins including free radical scavenging, modulation of neuroprotective signaling pathways, activation of neurotrophic factors, modulation of neurotransmitters, inhibition of BACE1 enzyme and tau hyper-phosphorylation. The study concludes that saponins have considerable efficacy against various pathological targets of neurological disorders, especially AD, and might be an important source of leads against neurodegenerative disorders.
Source: Molecules - October 11, 2022 Category: Chemistry Authors: Abduljawad Elawad Elkhalifa Ahmed Hamdoon Salim Ashraf Ayaz Hassan Bungau Tags: Review Source Type: research
Role of Nrf2 in Aging, Alzheimer's and Other Neurodegenerative Diseases
This article also highlights the Nrf2 structural and functional activities in healthy and disease states, and also discusses the current status of Nrf2 research and therapeutic strategies to treat aging and neurodegenerative diseases.PMID:36243357 | DOI:10.1016/j.arr.2022.101756
Source: Ageing Research Reviews - October 15, 2022 Category: Genetics & Stem Cells Authors: Mathew George Matthan Tharakan John Culberson Arubala P Reddy P Hemachandra Reddy Source Type: research
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases
Ageing Res Rev. 2022 Nov 9:101785. doi: 10.1016/j.arr.2022.101785. Online ahead of print.ABSTRACTAge-related diseases have become more common with the advancing age of the worldwide population. Such diseases involve multiple organs, with tissue degeneration and cellular apoptosis. To date, there is a general lack of effective drugs for treatment of most age-related diseases and there is therefore an urgent need to identify novel drug targets for improved treatment. Acid-sensing ion channel 1a (ASIC1a) is a degenerin/epithelial sodium channel family member, which is activated in an acidic environment to regulate pathophysio...
Source: Ageing Research Reviews - November 12, 2022 Category: Genetics & Stem Cells Authors: Ren-Peng Zhou Hong-Yu Liang Wei-Rong Hu Jie Ding Shu-Fang Li Yong Chen Ying-Jie Zhao Chao Lu Fei-Hu Chen Wei Hu Source Type: research
An analysis of neurovascular disease markers in the hippocampus of Tupaia chinensis at different growth stages
DiscussionIt was suggested that when the hippocampus of T. chinensis developed from day 15 to 3 months, the expression of oxidatively phosphorylated proteins and RPs would vary over time. Meanwhile, the hippocamppal protein expression profile of T. chinensis after 3 months had become stable. Moreover, the study underlines that, during the early development of the hippocampus of T. chinensis, energy demand increases while protein synthesis decreases. The mitochondria of T. chinensis changes with age, and the oxidative phosphorylation metabolic pathway of mitochondria is closely related to neurovascular diseases, such as str...
Source: Frontiers in Neurology - January 17, 2023 Category: Neurology Source Type: research
Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice
Food Funct. 2023 May 16. doi: 10.1039/d3fo00156c. Online ahead of print.ABSTRACTAloe emodin is a natural anthraquinone derived from aloe or rhubarb, showing anti-renal fibrosis, anti-atherosclerosis and anti-cancer effects. Aloe emodin also shows neuroprotective effects in ischemic stroke rats. Naturally, anthraquinone derivatives generally have the effect of inhibiting the transforming growth factor-β1 (TGF-β1) pathway. There is an increase in the calcium/calmodulin-dependent protein kinase II (CaMKII) and TGF-β1 levels in both Huntington's disease (HD) patients' brains and HD transgenic mice. Thus, we hypothesized tha...
Source: Atherosclerosis - May 16, 2023 Category: Cardiology Authors: Nan Yan Shuai Wang Haotian Gao Jiaqi Chen Jiahui Cao Pengsheng Wei Xue Li Ying Yu Yan Wang Yalin Niu Yijie Wang Shuyuan Liu Ge Jin Source Type: research
Is exercise actually good for the brain?
There are plenty of reasons to get off your duff and exercise—but is improving your brain one of them? The U.S. Centers for Disease Control and Prevention touts exercise as a way to “
boost brain health
,
” while the World Health Organization suggests that about 2 hours of moderate activity or 75 minutes of vigorous activity per week can
help improve thinking and memory skills
.
But new research reveals a more complex picture. One recent review of the literature suggests
the studies tying exercise to brain health may have important limitations
, including small sample sizes. Othe...
Source: ScienceNOW - June 30, 2023 Category: Science Source Type: news
Perspectives and new aspects of histone deacetylase inhibitors in the therapy of CNS diseases
Eur J Med Chem. 2023 Jun 29;258:115613. doi: 10.1016/j.ejmech.2023.115613. Online ahead of print.ABSTRACTMany populations worldwide are suffering from central nervous system (CNS) diseases such as brain tumors, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease) and stroke. There is a shortage of effective drugs for most CNS diseases. As one of the regulatory mechanisms of epigenetics, the particular role and therapeutic benefits of histone deacetylases (HDACs) in the CNS have been extensively studied. In recent years, HDACs have attracted increasing attention as potential drug ta...
Source: European Journal of Medicinal Chemistry - July 3, 2023 Category: Chemistry Authors: Bo Han Mengfei Wang Jiayi Li Qiushi Chen Niubing Sun Xuezhi Yang Qingwei Zhang Source Type: research
Ataxia and hyperkinetic movement disorders
Hyperkinetic movement disorders comprise excessive involuntary movements, the different types of movement having characteristic clinical features. Ataxia is a disorder of impaired coordination and balance, most commonly caused by cerebellar pathology. Sensory ataxia occurs when the pathways conveying proprioceptive sensory information are impaired. Chorea is a random writhing involuntary movement that can be caused by acute medical causes such as stroke and hyperglycaemia. Huntington disease is the most common cause of progressive chorea.
Source: Medicine - July 24, 2023 Category: Internal Medicine Authors: Christopher Kobylecki Tags: Movement disorders Source Type: research
The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds
Eur J Pharmacol. 2023 Aug 5:175966. doi: 10.1016/j.ejphar.2023.175966. Online ahead of print.ABSTRACTAberrant innate immunity in the brain has been implicated in the pathogenesis of several central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, amyotrophic lateral sclerosis, and depression. Except for extraparenchymal CNS-associated macrophages, which predominantly afford protection against peripheral invading pathogens, it has been reported that microglia, a population of macrophage-like cells governing CNS immune defense in nearly all neurological disease...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Hua Fan Qianqian Bai Yang Yang Xiaofei Shi Ganqin Du Junqiang Yan Jian Shi Dongmei Wang Source Type: research
