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Specialty: Neurology
Condition: Heatstroke

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Total 26 results found since Jan 2013.

Acute Vertebrobasilar Territory Infarcts due to Heat Stroke
We report an unusual case of acute vertebrobasilar territory infarcts due to heat stroke. A middle-aged man developed hyperpyrexia (42.2°C) after strenuous fieldwork in a hot summer day. Next morning, he was found in altered sensorium. The brain imaging showed acute posteromedial midbrain and cerebellar infarcts. A diagnosis of acute ischemic stroke due to heat stroke was made, and the patient was put under the intensive care unit.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2015 Category: Neurology Authors: Rajendra Singh Jain, Sunil Kumar, Rakesh Agarwal, Pankaj Kumar Gupta Tags: Case Report Source Type: research

Analysis of Clinical Symptoms and Brain MRI of Heat Stroke: 2 Case Reports and a Literature Review
Introduction: Heat stroke is defined as high body temperature causing multiple organ failure, psychological change, seizure, and consciousness disturbance, which lead to its high mortality rate. However, the involvement of brain injury is rare, and heat-stroke has only been reported in a few case reports or case series. The purpose of this case study was to evaluate the clinical symptoms and radiological features of heat stroke. Methods: We reviewed our hospital records and previously published reports to find cases of heat stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 25, 2019 Category: Neurology Authors: Tomoyo Shimada, Nobukazu Miyamoto, Yoshiaki Shimada, Masao Watanabe, Hideki Shimura, Yuji Ueno, Kazuo Yamashiro, Nobutaka Hattori, Takao Urabe Source Type: research

Unusual manifestation of heat stroke: Isolated trochlear nerve palsy
Heat stroke is a life-threatening disease characterized by hyperthermia and neurological dysfunction. The central nervous system is highly sensitive to hyperthermia, which causes neurological complications due to the involvement of the cerebellum, basal ganglia, anterior horn cells, and peripheral nerves. Several studies reported about clinical symptoms and brain image findings of heat stroke. Isolated cranial nerve dysfunction caused by lacunar infarction is an extremely rare condition in patient with heat stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Sanghoon Han, Baik-kyun Kim, Kyu Sun Yum Tags: Case report Source Type: research

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Both conditions are characterized by disturbed homeostasis in which inflammatory pathways play a central role. Splanchnic vasoconstriction, increased gut permeability, gut-related endotoxemia, systemic inflammatory response, central nervous system dysfunction, blood coagulation disorder, endothelial-cell injury, and mitochondrial dysfunction underlie heat stroke. These mechanisms have also been documented in ME/CFS. Moreover, initial transc...
Source: Frontiers in Neurology - December 13, 2021 Category: Neurology Source Type: research

Analysis of Clinical Symptoms of Guillain –Barré Syndrome Induced by Heat Stroke: Three Case Reports and Literature Review
ConclusionsThe number of the cases of GBS induced by HS reported in this study has been the most in the recent 5 years. Clinicians should pay attention to patients with heat stroke with sustained coma and the sudden quadriplegia. Early, exact and timely diagnosis and treatment of GBS need to be performed, to accelerate recovery and improve prognosis.
Source: Frontiers in Neurology - June 17, 2022 Category: Neurology Source Type: research

Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies
Prog Brain Res. 2021;266:301-348. doi: 10.1016/bs.pbr.2021.06.014. Epub 2021 Oct 6.ABSTRACTMilitary personnel are often exposed to high environmental heat associated with industrial or ambient abundance of nanoparticles (NPs) affecting brain function. We have shown that engineered metal NPs Ag and Cu exacerbate hyperthermia induced brain pathology. Thus, exploration of novel drug therapy is needed for effective neuroprotection in heat stroke intoxicated with NPs. In this investigation neuroprotective effects of cerebrolysin, a balanced composition of several neurotrophic factors and active peptides fragments exhibiting pow...
Source: Brain Research - October 25, 2021 Category: Neurology Authors: Hari Shanker Sharma Dafin F Muresanu Asya Ozkizilcik Seaab Sahib Z Ryan Tian Jos é Vicente Lafuente Rudy J Castellani Ala Nozari Lianyuan Feng Anca D Buzoianu Preeti K Menon Ranjana Patnaik Lars Wiklund Aruna Sharma Source Type: research

Mesenchymal stem cell ‐based treatments for stroke, neural trauma, and heat stroke
ConclusionThis review offers a testable platform for targeting microglial‐mediated cytokines in clinical trials based upon the rational design of MSC therapy in the future. MSCs that are derived from the placenta provide a great choice for stem cell therapy. Although targeting the microglial activation is an important approach to reduce the burden of the injury, it is not the only one. This review focuses on this specific aspect. Ischemic stroke, neural trauma, and heatstroke all cause cerebral ischemia‐related deficits. Exogenous MSC therapy is promising as a means of augmenting brain ischemia‐induced deficits. MSC...
Source: Brain and Behavior - August 2, 2016 Category: Neurology Authors: Yogi Chang ‐Yo Hsuan, Cheng‐Hsien Lin, Ching‐Ping Chang, Mao‐Tsun Lin Tags: Review Source Type: research

Diffusion tensor imaging of the cerebellum in patients after heat stroke
Abstract To explore the application value of cerebellar diffusion tensor imaging (DTI) in patients after heat stroke (HS). Eleven patients after HS with a score of 3–9 in Glasgow Coma Scale (GCS) and seven age-matched healthy volunteers were selected to undergo MR examinations during the same hot summer. The MR studies including DTI were performed with a 1.5 T scanner. Fractional anisotropy (FA) values of normal-appearing cerebellar white and gray matter were measured and the differences between the two groups were evaluated with Mann–Whitney U test. The FA value of normal-appearing cerebellar white matte...
Source: Acta Neurologica Belgica - May 20, 2015 Category: Neurology Source Type: research

Heat Stroke from Prolonged Sauna Producing Bilateral Thalamic and Brainstem Hyperintensities on Diffusion-Weighted MRI (P4.400)
Conclusions: We present a case of prolonged hyperthermia producing marked, reversible restricted diffusion in the thalami and brainstem and with a good clinical outcome despite the severity of the initial deficit and imaging findings. This report illustrates the potential reversibility of thermal brain insults and some of the characteristic findings of MR imaging.Disclosure: Dr. Fois has nothing to disclose. Dr. Farrar has nothing to disclose. Dr. Tisch has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Fois, A., Farrar, T., Tisch, S. Tags: General Neurology: Imaging in Clinical Diagnosis Source Type: research

Magnetic resonance imaging and magnetic resonance venography features in heat stroke: a case report
Heat stroke (HS) is a critical illness that can cause multiple organ dysfunction, including damage to the central nervous system (CNS), which can be life-threatening in severe cases. Brain lesions in patients ...
Source: BMC Neurology - June 18, 2019 Category: Neurology Authors: Lizhi Cao, Juan Wang, Yaxuan Gao, Yumei Liang, Jinhua Yan, Yunhai Zhang, Mingqin Zhu, Tianfei Luo and Jiafeng Chen Tags: Case report Source Type: research

Mesenchymal Stem Cells Provide Neuroprotection by Regulating Heat Stroke-Induced Brain Inflammation
Heat stroke (HS) is the most acute type of heat illness accompanied with serious central nervous system (CNS) dysfunction. Despite the pathological process being clearly studied, effective treatment is deficient. Currently, mesenchymal stem cells (MSCs) have been demonstrated to have neuroprotective effects as there are no old ones. Thus, the purpose of the present study was to explore the neuroprotective effects and mechanisms of MSCs against HS-induced CNS injury. HS in rat models was induced by a high-temperature environment and treated with MSCs via the tail vein. The results demonstrated that MSC injection significant...
Source: Frontiers in Neurology - May 4, 2020 Category: Neurology Source Type: research

NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1 β-mediated neuroinflammation
Patients with prior illness are more vulnerable to heat stroke-induced injury, but the underlying mechanism is unknown. Recent studies suggested that NLRP3 inflammasome played an important role in the pathophy...
Source: Journal of Neuroinflammation - June 6, 2021 Category: Neurology Authors: Zi-Teng Zhang, Xiao-Lei Gu, Xin Zhao, Xian He, Hao-Wei Shi, Kun Zhang, Yi-Ming Zhang, Yi-Nan Su, Jiang-Bo Zhu, Zhi-Wei Li and Guo-Bao Li Tags: Research Source Type: research

Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke
Prog Brain Res. 2021;265:249-315. doi: 10.1016/bs.pbr.2021.06.007. Epub 2021 Aug 12.ABSTRACTMilitary personnel often exposed to high summer heat are vulnerable to heat stroke (HS) resulting in abnormal brain function and mental anomalies. There are reasons to believe that leakage of the blood-brain barrier (BBB) due to hyperthermia and development of brain edema could result in brain pathology. Thus, exploration of suitable therapeutic strategies is needed to induce neuroprotection in HS. Extracts of Gingko Biloba (EGb-761) is traditionally used in a variety of mental disorders in Chinese traditional medicine since ages. I...
Source: Brain Research - September 25, 2021 Category: Neurology Authors: Seaab Sahib Aruna Sharma Dafin F Muresanu Zhiqiang Zhang Cong Li Z Ryan Tian Anca D Buzoianu Jos é Vicente Lafuente Rudy J Castellani Ala Nozari Ranjana Patnaik Preeti K Menon Lars Wiklund Hari Shanker Sharma Source Type: research