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Total 106 results found since Jan 2013.
Medical News Today: Testosterone therapy may reduce cardiovascular risk in older men
Researchers have observed that patients whose low testosterone levels returned to normal with therapy also experienced a reduced risk of heart attack and stroke.
Source: Health News from Medical News Today - August 11, 2015 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news
Testosterone Therapy Isn't All It's Cracked Up To Be, Study Finds
Millions of men, mostly over the age of 50, are now using testosterone therapy to treat a broad array of symptoms -- erectile dysfunction, weight gain, listlessness -- thought to be caused by low testosterone levels, which the pharmaceutical industry in copious advertising calls "Low-T." But a major new study from a team of researchers at Brigham and Women's Hospital in Boston -- one of the biggest double-blinded studies of the therapy so far -- indicates that testosterone doesn't work as advertised. The team, led by endocrinologist Dr. Shalender Bhasin, gave 306 men over the age of 60, all of whom had low ...
Source: Science - The Huffington Post - August 11, 2015 Category: Science Source Type: news
Testosterone therapy may reduce cardiovascular risk in older men
A study in the European Heart Journal has looked at 83,000 patients in the Veteran Affairs database and found that men with low testosterone treated with replacement therapy also experienced a reduced risk of heart attack, stroke and all-cause mortality.
Medical News Today
Source: Society for Endocrinology - August 12, 2015 Category: Endocrinology Source Type: news
Medical News Today: Testosterone therapy may improve heart health for older men
Researchers have observed that patients whose low testosterone levels returned to normal with therapy also experienced a reduced risk of heart attack and stroke.
Source: Health News from Medical News Today - August 12, 2015 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news
Testosterone replacement and cardiovascular disease risk: what do endocrinologists need to know?
Testosterone deficiency (or hypogonadism) affects millions of men worldwide. Consensus regarding an appropriate biochemical cutoff for the definition and treatment of hypogonadism has been challenging. Several recent, well-publicized studies have called into question the long recognized benefits of testosterone replacement therapy. The aim of the current article is to review the data on testosterone treatment, paying specific attention to the potential cardiovascular effects of this increasingly common therapy. We examine some of the most common cardiovascular diseases including hypertension, metabolic syndrome, coronary a...
Source: Cardiovascular Endocrinology - August 14, 2015 Category: Cardiology Tags: Invited reviews Source Type: research
Low testosterone and sexual symptoms in men with acute coronary syndrome can be used to predict major adverse cardiovascular events during long‐term follow‐up
Summary
Low total testosterone (TT) and sexual symptoms are common among men with coronary artery disease, however its impact on major adverse cardiovascular events (MACE) is still debatable. We investigated whether low TT and coexisting sexual symptoms in men with acute coronary syndrome (ACS) can be used to predict the incidence of MACE. In the prospective study 120 consecutive men (mean age 58 ± 9 years; diabetes 27%; current smokers 58%; left ventricular ejection fraction 50 ± 10%) with ACS were included. The group of men with the presence of three sexual symptoms (decreased frequency of morning erections, a lac...
Source: Andrology - September 1, 2015 Category: Urology & Nephrology Authors: A. Chmiel, K. Mizia‐Stec, J. Wierzbicka‐Chmiel, S. Rychlik, A. Muras, M. Mizia, J. Bienkowski Tags: Original Article Source Type: research
Testosterone and Cardiovascular Disease
Testosterone (T) is the principal male sex hormone. As men age, T levels typically fall. Symptoms of low T include decreased libido, vasomotor instability, and decreased bone mineral density. Other symptoms may include depression, fatigue, erectile dysfunction, and reduced muscle strength/mass. Epidemiology studies show that low levels of T are associated with more atherosclerosis, coronary artery disease, and cardiovascular events. However, treating hypogonadism in the aging male has resulted in discrepant results in regard to its effect on cardiovascular events. Emerging studies suggest that T may have a future role in t...
Source: Journal of the American College of Cardiology - February 2, 2016 Category: Cardiology Source Type: research
Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus.
Authors: Kautzky-Willer A, Harreiter J, Pacini G
Abstract
T2DM is more frequently diagnosed at lower age and body-mass-index in men, however the most prominent risk factor, which is obesity, is more common in women. Generally, large sex-ratio differences across countries are observed. Diversities in biology, culture, lifestyle, environment and socioeconomic status impact differences between males and females in predisposition, development and clinical presentation. Genetic effects and epigenetic mechanisms, nutritional factors and sedentary lifestyle affect risk and complications differently in both sexes. Furtherm...
Source: Endocrine Reviews - May 11, 2016 Category: Endocrinology Tags: Endocr Rev Source Type: research
Controversial Effects of Exogenous Testosterone on Cardiovascular Diseases
The use of testosterone (T) among men aged 40 years or older was increased more than 3 times from 0.81% in 2001 to 2.91% in 2011. Until recently, the majority of the studies did not show any increased cardiovascular (CV) risk by using T in male patients with hypogonadism. What is more, some studies had observed a protective effect of using T against CV diseases. However, in 2010, a randomized clinical trial (RCT) was intended to study the advantage of T gel in older men with limitations in mobility; the study was stopped due to unexpected high prevalence of CV adverse outcome. These findings were confirmed by 2 other studi...
Source: American Journal of Therapeutics - November 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research
‘Forever Young’†—Testosterone replacement therapy: a blockbuster drug despite flabby evidence and broken promises
<span class="paragraphSection"><div class="boxTitle">Abstract</div>In the last decade, testosterone replacement therapy (TRT) has been increasingly prescribed to treat a controversial condition known as ‘late-onset hypogonadism (LOH)’. This syndrome is diagnosed in men who, for no discernible reason other than older age, obesity or ill health have serum testosterone concentrations below the normal range for healthy young men and report one or more of the following symptoms: muscle weakness or wasting, mood, behaviour and cognition-related symptoms and sexual function or libido impairment. However, rec...
Source: Human Reproduction - February 22, 2017 Category: Reproduction Medicine Source Type: research
Expanding the phenotype of phosphomannomutase-2 gene congenital disorder of glycosylation: Cervical dystonia
Phosphomannomutase-2 deficiency-congenital disorder of glycosylation (PMM2-CDG), congenital disorder of glycosylation type-Ia or Jaeken syndrome (MIM #601785) is an autosomal recessive inherited condition of abnormal glycosylation of N-linked oligosaccharides [1]. Disease course is variable, ranging from infantile forms with multisystem involvement and a childhood-adult ataxia-intellectual disability type with neurologic stable form [1,2]. The phenotypic spectrum includes morphological abnormalities, ataxia, developmental delay, strabismus, retinopathy, seizures, stroke-like episodes, peripheral neuropathy, hypergonadotrop...
Source: Journal of the Neurological Sciences - April 23, 2017 Category: Neurology Authors: Malco Rossi, Alex Medina Escobar, Lucia Ameghino, Marcelo Merello Tags: Letter to the Editor Source Type: research
Testosterone replacement lowers cardiovascular disease risk in secondary hypogonadism
Testosterone replacement therapy may lower the risk for myocardial infarction, stroke and all-cause mortality in men with secondary hypogonadism, according to research presented at the Annual Scientific and Clinical Congress.Healio
Source: Society for Endocrinology - May 8, 2017 Category: Endocrinology Source Type: news
Prediabetes
is a complex multifactorial metabolic disorder that extends beyond glucose control. Current studies have found that microvascular disease (neuropathy, nephropathy, and retinopathy), macrovascular disease (stroke, coronary artery disease, and peripheral vascular disease), periodontal disease, cognitive dysfunction, blood pressure changes, obstructive sleep apnea, low testosterone level, fatty liver disease, and cancer are some of conditions that are present with the onset of glycemic dysregulation. The presence of prediabetes increases the risk of developing type 2 diabetes 3-fold to 10-fold. The identification and treatme...
Source: Nursing Clinics of North America - October 6, 2017 Category: Nursing Authors: Mara Lynn Wilson Source Type: research
FDA Drug Safety Communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use
[03-03-2015] The U.S. Food and Drug Administration (FDA) cautions that prescription testosterone products are approved only for men who have low testosterone levels caused by certain medical conditions.
Source: FDA Center for Drug Evaluation and Research - What's New - December 11, 2017 Category: Drugs & Pharmacology Source Type: news
