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Condition: Hives
Drug: Aspirin

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Total 39 results found since Jan 2013.

Corrigendum
With regard to the article in the December 2022 issue entitled “Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization” (J Allergy Clin Immunol 2022;150:1486-97), the accession number for the original sequence data was not included. The GEO accession number is GSE219154 an d the data is available at: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE219154.
Source: Journal of Allergy and Clinical Immunology - March 1, 2023 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

Recent Updates in Understanding NSAID Hypersensitivity
AbstractPurpose of ReviewTo provide a review of available literature regarding nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with an emphasis on more recent findings.Recent FindingsOral provocation tests with aspirin are important for diagnosis and management in adult and pediatric populations with reported NSAID hypersensitivity. Risk of cross-reactivity to COX-2 inhibitors varies by NSAID hypersensitivity phenotype. COX-2 inhibitors are tolerated in aspirin-exacerbated respiratory disease. Reported NSAID allergy is associated with a higher risk of a substance use disorder. Effective treatment of underlying...
Source: Current Allergy and Asthma Reports - February 9, 2023 Category: Allergy & Immunology Source Type: research

Reply
We thank Cornejo-Garc ía et al1 for their interest in our article "Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization."2 We agree that patient selection is important in biomarker discovery and had acknowledged the limitations in t he article. As explained in the discussion, we had adopted a pragmatic approach in patient recruitment, as the patients with nonsteroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema (NIUA) had active coronary artery disease requiring aspirin before urgent percutaneous coronary interv ention.
Source: Journal of Allergy and Clinical Immunology - December 19, 2022 Category: Allergy & Immunology Authors: Sen Hee Tay, Amelia Santosa, Bernett Teck Kwong Lee, Paul Lorenz Bigliardi Tags: Correspondence Source Type: research

Accurate phenotyping of cross-reactive hypersensitivity is essential to shed light on the underlying mechanisms in NSAID-induced urticaria/angioedema
The article "Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization" by Tay et  al1 in The Journal of Allergy and Clinical Immunology tries to characterize transcriptomic and metabolomic profiles in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema (NIUA) who are undergoing aspirin desensitization. Patients were included exclusively on the basis of clinical history, without an aspirin drug provocation test (DPT).
Source: Journal of Allergy and Clinical Immunology - December 19, 2022 Category: Allergy & Immunology Authors: Jos é Antonio Cornejo-García, Rafael Núñez, María J. Torres, Inmaculada Doña Tags: Correspondence Source Type: research

To challenge or avoid? possible aspirin allergy in patients with chronic idiopathic urticaria and angioedema
Aspirin remains an important component of dual antiplatelet therapy following percutaneous coronary intervention (PCI). Despite studies showing safety in discontinuing aspirin post PCI through use of P2Y12 inhibitor therapy plus anticoagulation, no large, randomized trials evaluate an initial aspirin-free regimen post PCI without systemic anticoagulation. Aspirin intolerances occur in 20% of patients, with only 2% being true allergies. Most aspirin intolerances are linked to asthma, rhinitis, and chronic idiopathic urticaria (CIU).
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: J. Wealing, R. Chester, K. Khalsa Tags: M006 Source Type: research

Distinct Transcriptomic and Metabolomic Profiles Characterize NSAID-Induced Urticaria/Angioedema Patients Undergoing Aspirin Desensitization
This study combines both transcriptomic and metabolomic approaches to identify an unique mRNA gene signature and lower baseline salicylic acid levels in patients with NSAID-induced urticaria/angioedema, contributing to a deeper understanding about its pathogenesis.
Source: Journal of Allergy and Clinical Immunology - August 11, 2022 Category: Allergy & Immunology Authors: Sen Hee Tay, Amelia Santosa, Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu, Mei Bigliardi-Qi, Leroy Sivappiragasam S/O. Pakkiri, Bernett Teck Kwong Lee, Chester Lee Drum, Paul Lorenz Bigliardi Source Type: research

The Editors ’ Choice
Basophils are potent granulocytes that have long been associated with type 2 inflammation and characterized in food allergy, asthma, and urticaria. Less is known currently about the role basophils play in another type 2 inflammatory condition, aspirin-exacerbated respiratory disease (AERD). AERD is clinically comprised of the triad of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and intolerance of nonsteroidal anti-inflammatory drugs (NSAIDs). Patients with AERD typically have more severe CRSwNP but the underlying mechanisms contributing to this enhanced disease are not fully understood.
Source: Journal of Allergy and Clinical Immunology - August 1, 2021 Category: Allergy & Immunology Tags: The Editors ’ choice Source Type: research

NSAID hypersensitivity in CSU in the light of its pathogenesis
Eur Ann Allergy Clin Immunol. 2021 Jul 21. doi: 10.23822/EurAnnACI.1764-1489.227. Online ahead of print.ABSTRACTUp to 15% of patients with chronic spontaneous urticaria (CSU) experience severe exacerbations of their baseline cutaneous disease after taking nonsteroidal anti-inflammatory drugs that inhibit cycloxygenase-1 (COX-1) enzyme. These subjects are defined as having a NECD (NSAID-exacerbated cutaneous disease). The way NSAID hypersensitivity correlates with the different pathogenic mechanisms of CSU has not been investigated so far. 235 adults with severe CSU submitted to omalizumab treatment were studied. A rapid om...
Source: European Annals of Allergy and Clinical Immunology - July 21, 2021 Category: Allergy & Immunology Authors: R Asero Source Type: research

Serum Human β-Defensin 2 Is Increased in Angioedema Accompanying Chronic Spontaneous Urticaria
Conclusion: A known mast-cell degranulator, HBD2 was elevated in the sera from CSU patients compared to healthy controls and may be involved in the pathogenesis of accompanying angioedema.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - June 17, 2021 Category: Allergy & Immunology Source Type: research

Aspirin desensitization as a treatment in patients with aspirin-sensitive chronic urticaria
Some patients with chronic spontaneous urticaria (CSU) experience their symptoms aggravated or induced when exposed to nonsteroidal anti-inflammatory drugs (NSAIDs), called as NSAIDs-exacerbated chronic urticaria. Their clinical manifestations are often more recalcitrant than in aspirin-tolerant cases, even with complete avoidance of the drugs. Aspirin desensitization has rarely been attempted for aspirin-sensitive CSU.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Jaechun Lee Source Type: research

Genetic Association between CYSLTR2 Polymorphisms and Nonsteroidal Anti-inflammatory Drugs-induced urticaria/angioedema
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most highly consumed medicines, but they are also the main responsible for drug hypersensitivity reactions (DHRs). Cyclooxygenase-1 (COX-1) inhibition diverts arachidonic acid metabolism towards cysteinyl-leucotrienes (CysLTs), which trigger a DHR in susceptible individuals after interacting with specific receptors. Genetics of DHRs to NSAIDs have focused mainly on aspirin-exacerbated respiratory disease (AERD); however, aspirin-induced acute urticaria/angioedema (AIAU) is the most frequent clinical phenotype.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Raquel Jurado Escobar, Melanie Pareja-Mart Ãn, Inmaculada Doña, Natalia Perez-Sanchez, James Perkins, Gador Bogas Herrera, Joan Bartra, Maria ISIDORO GARCÍA, Jose Laguna, Cristobalina Mayorga, Maria Torres Jaen, Jose Cornejo-Garcia Source Type: research

Higher Dose Starting Protocols In Coronary Artery Disease Patients With Aspirin Hypersensitivity
Aspirin is first-line treatment in coronary artery disease (CAD) patients, but in patients with acute coronary syndrome (ACS) or who require dual antiplatelet therapy after myocardial revascularization, aspirin therapy becomes critical and time-sensitive1. Approximately 1.5% of CAD patients report aspirin allergy2. Most reactions are considered non-immunologic, related to aspirin ’s inhibition of cyclo-oxygenase causing allergic-like symptoms3. A subset of patients has aspirin exacerbated respiratory disease (AERD) or chronic idiopathic urticaria (CIU) exacerbated by aspirin.
Source: Annals of Allergy, Asthma and Immunology - August 21, 2019 Category: Allergy & Immunology Authors: Emily H. Liang, Cy Y. Kim, Javed Sheikh, Shefali A. Samant Tags: Letters Source Type: research

Higher-starting-dose protocols in patients with coronary artery disease and aspirin hypersensitivity
Aspirin is first-line treatment in patients with coronary artery disease (CAD), but in patients with acute coronary syndrome (ACS) or those who require dual antiplatelet therapy after myocardial revascularization, aspirin therapy becomes critical and time sensitive.1 Approximately 1.5% of patients with CAD report aspirin allergy.2 Most reactions are considered nonimmunologic, related to aspirin's inhibition of cyclooxygenase that causes allergic-like symptoms.3 A subset of patients have aspirin-exacerbated respiratory disease (AERD) or chronic idiopathic urticaria (CIU) exacerbated by aspirin.
Source: Annals of Allergy, Asthma and Immunology - August 21, 2019 Category: Allergy & Immunology Authors: Emily H. Liang, Cy Y. Kim, Javed Sheikh, Shefali A. Samant Tags: Letters Source Type: research

New phenotypes in hypersensitivity reactions to nonsteroidal anti-inflammatory drugs
Purpose of review Nonsteroidal anti-inflammatory drug (NSAID) is one of the most frequently prescribed medications in the medical field, and hypersensitivity to NSAID is a common adverse drug reaction encountered. However, NSAID hypersensitivity presents a variety of symptoms caused by diverse pharmacological and immunological mechanisms. Recent findings Owing to the heterogeneity of the disease, a new concept for the classification of NSAID hypersensitivity has recently been proposed to diagnose and manage NSAID hypersensitivity for personalized treatment. Acute and delayed reactions were distinguished in this classi...
Source: Current Opinion in Allergy and Clinical Immunology - June 27, 2019 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research