New phenotypes in hypersensitivity reactions to nonsteroidal anti-inflammatory drugs

Purpose of review Nonsteroidal anti-inflammatory drug (NSAID) is one of the most frequently prescribed medications in the medical field, and hypersensitivity to NSAID is a common adverse drug reaction encountered. However, NSAID hypersensitivity presents a variety of symptoms caused by diverse pharmacological and immunological mechanisms. Recent findings Owing to the heterogeneity of the disease, a new concept for the classification of NSAID hypersensitivity has recently been proposed to diagnose and manage NSAID hypersensitivity for personalized treatment. Acute and delayed reactions were distinguished in this classification, and identification of symptoms and speculation of putative mechanisms help physicians make the right diagnosis. NSAID-exacerbated respiratory disease is a noticeable phenotype of NSAID hypersensitivity that involves upper airway comorbidities (chronic rhinosinusitis with nasal polyps) as well as asthmatic features. The cutaneous phenotypes of NSAID hypersensitivity occur, and cross-reactivity with other types of NSAID should be considered in establishing a proper diagnosis. Hypersensitivity to a single NSAID can present urticaria/angioedema and anaphylaxis, in which an IgE-mediated immune response is suggested to be a prime mechanism. Management of NSAID hypersensitivity reactions includes avoidance, pharmacological treatment following standard guidelines, and aspirin desensitization. Summary The classification, diagnosis, and management of NSAI...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research

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Over 2.6 million ED visits across the United States result in a primary diagnosis of urinary tract infection.1 While much attention has been paid to reducing blood culture contamination rates in the emergency department,2-9 a substantial gap remains in projects aimed at reducing contamination in clean-catch urine specimens obtained in the ED setting. Obtaining an adequate urine culture is clinically important to the care of several vulnerable patient groups, including patients with diabetes or compromised immune responses, those with high risk for subsequent urosepsis, previous antibiotic resistant infections, multiple ant...
Source: Journal of Emergency Nursing: JEN - Category: Nursing Authors: Tags: Editorial Source Type: research
You're reading Testicular pain: Everything you need to know as a parent, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Does your of age son often complain about the pain in testicles? Does he feel uncomfortable while riding his bicycles or bike? If yes! It could be testicular pain which mostly occurs among teenage boys.  It’s very uncommon to see the pain in boys above 25 years old. Testicular pain often requires immediate medical attention. If the treatment is started within 6 hrs of beginning of the pain, ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Causes of Testicular Pain in Children Kidshealth Testicle Pain Testicle Pain in Children Testicular Pain in Kids Source Type: blogs
People who have allergies may be in for a rough ragweed season this summer and fall, thanks to hotter and wetter weather nationwide.
Source: WebMD Health - Category: Consumer Health News Source Type: news
(Natural News) Spring and summer makes flowers bloom, but for people with seasonal allergies, it’s one more reason to hate flower pollen and other allergens. If you’re tired of symptoms like a runny nose and watery eyes, try natural foods and supplements like butterbur or omega-3 fatty acids to relieve your seasonal allergies. At least...
Source: - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Background: Symptoms of posttraumatic stress disorder (PTSD) have been observed in patients with life-threatening health conditions, ranging from cancer to asthma. Autoimmune blistering diseases (AIBD) are chronic, relapsing diseases that significantly impair quality of life in affected patients. Growing evidence has indicated a high degree of psychological distress associated with AIBD. Indeed, even during disease remission, many patients with AIBD can experience nonspecific symptoms similar that elicit significant anxiety and fear of recurrence of their skin disease.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Psoriasis, psoriatic arthritis, atopic dermatitis (AD), hidradenitis suppurativa (HS) and chronic urticaria (CU) are associated with sleep disturbances (SD). Validated, disease-specific instruments are needed to assess SD in these populations. This work focuses on the development of the ‘PsO Sleepy-Q’ for psoriasis and ‘PsA Sleepy-Q’ for psoriatic arthritis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
AbstractNon-steroidal anti-inflammatory drugs (NSAID) are the second most common trigger of drug hypersensitivity in adults and children and are considered the most common or second most common cause of drug-induced anaphylaxis. NSAID hypersensitivity reactions are classified according to the latency of symptoms in relation to ingestion and on the basis of symptoms, potential underlying disease (chronic urticaria, bronchial asthma/chronic rhinosinusitis/nasal polyps), cross-reactivity to other NSAID, and the suspected pathomechanism. The diagnosis and management of NSAID hypersensitivity depend on the confirmed or suspecte...
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell li...
Source: World Allergy Organization Journal - Category: Allergy & Immunology Source Type: research
Abstract The off-label use of medicines is a common and extensive clinical practice. Omalizumab has been licensed for use in severe allergic asthma and chronic urticaria. Omalizumab dosing was based on body weight and baseline serum IgE concentration. All patients are required to have a baseline IgE between 30 and 700 IU/ml and body weight not more than 150 kg. The use of off-label drugs may lead to several problems including adverse effects and an increased risk/benefit balance. In this article, there are summarized off-label uses of omalizumab in the last recent years in diseases in which IgE maybe or ...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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