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Incident heart failure in outpatients with chronic coronary syndrome: results from the international prospective CLARIFY registry
ConclusionA sizeable proportion of patients with chronic coronary syndrome develop HF, which only infrequently requires hospitalization. Early identification of patients with HF may lead to early treatment, and help to further decrease mortality and morbidity. This concept needs confirmation in future studies.
Source: European Journal of Heart Failure - April 14, 2020 Category: Cardiology Authors: Zofia Parma, Adam Jasilek, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim Fox, Jean ‐Claude Tardif, Michal Tendera, P. Gabriel Steg Tags: Research Article Source Type: research

Good news and bad news: Changing trends in cardiovascular disease in Canada
(Elsevier) An analysis of patient records in Canada provides important new insights into changing patterns of inpatient healthcare utilization. Between 2007 and 2016, standardized hospitalization rates declined for coronary artery and vascular disease, heart rhythm disorders, stroke, and heart failure but increased for some important conditions: acquired valvular heart disease; vascular cognitive impairment; and congenital heart disease. The study appears in the Canadian Journal of Cardiology, published by Elsevier.
Source: EurekAlert! - Medicine and Health - July 2, 2020 Category: International Medicine & Public Health Source Type: news

Patterns Changing for Heart Disorder Hospitalizations in Canada
FRIDAY, July 10, 2020 -- Standardized hospitalization rates declined for coronary artery and vascular disease, heart rhythm disorders, stroke, and heart failure in Canada from 2007 through 2016, according to a study published online July 1 in the...
Source: Drugs.com - Pharma News - July 10, 2020 Category: Pharmaceuticals Source Type: news

Antiarrhythmic and cardiac electrophysiological effects of SZV-270, a novel compound with combined Class I/B and Class III effects, in rabbits and dogs.
In conclusion, SZV-270 with its combined Class I/B and III effects can prevent re-entry arrhythmias with reduced risk of provoking drug-induced Torsades de Pointes. PMID: 32970956 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - September 23, 2020 Category: Drugs & Pharmacology Authors: Varga RS, Hornyik T, Husti Z, Kohajda Z, Krajsovszky G, Nagy N, Jost N, Virág L, Tálosi L, Mátyus P, Varró A, Baczkó I Tags: Can J Physiol Pharmacol Source Type: research

The Impact of Sex and Gender on Heart-Brain Axis Dysfunction: Current Concepts and Novel Perspectives.
Abstract The Heart-Brain Axis (HBA) recapitulates all the circuits that regulate bidirectional flow of communication between heart and brain. Several mechanisms may underlie the interdependent relationship involving heterogeneous tissues at rest and during specific target organ injury, such as myocardial infarction, heart failure, arrhythmia, stroke, mood disorders or dementia. In-depth translational studies of the HBA dysfunction under single-organ injury should include both male and female animals to develop sex/gender-oriented prevention, diagnosis and treatment strategies. Indeed, sex and gender are determinin...
Source: Canadian Journal of Physiology and Pharmacology - September 30, 2020 Category: Drugs & Pharmacology Authors: Baroni C, Lionetti V Tags: Can J Physiol Pharmacol Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Bedtime versus morning use of antihypertensives for cardiovascular risk reduction (BedMed): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial
Introduction Sleep-time blood pressure correlates more strongly with adverse cardiovascular events than does daytime blood pressure. The BedMed trial evaluates whether bedtime antihypertensive administration, as compared with conventional morning use, reduces major adverse cardiovascular events. Methods and analysis Design Prospective randomised, open-label, blinded end-point trial. Participants Hypertensive primary care patients using blood pressure lowering medication and free from glaucoma. Setting Community primary care providers in 5 Canadian provinces (British Columbia, Alberta, Saskatchewan, Manitoba and Ontario) a...
Source: BMJ Open - February 24, 2022 Category: General Medicine Authors: Garrison, S. R., Kolber, M. R., Allan, G. M., Bakal, J., Green, L., Singer, A., Trueman, D. R., McAlister, F. A., Padwal, R. S., Hill, M. D., Manns, B., McGrail, K., O'Neill, B., Greiver, M., Froentjes, L. S., Manca, D. P., Mangin, D., Wong, S. T., MacLea Tags: Open access, Cardiovascular medicine Source Type: research

IJERPH, Vol. 19, Pages 11243: High Temperatures and Cardiovascular-Related Morbidity: A Scoping Review
Piotr Wilk The primary objective of this review was to synthesize studies assessing the relationships between high temperatures and cardiovascular disease (CVD)-related hospital encounters (i.e., emergency department (ED) visits or hospitalizations) in urban Canada and other comparable populations, and to identify areas for future research. Ovid MEDLINE, EMBASE, CINAHL, Cochrane Database of Systematic Reviews, and Scopus were searched between 6 April and 11 April 2020, and on 21 March 2021, to identify articles examining the relationship between high temperatures and CVD-related hospital encounters. Studies involvin...
Source: International Journal of Environmental Research and Public Health - September 7, 2022 Category: Environmental Health Authors: Kendra R. Cicci Alana Maltby Kristin K. Clemens Ana Maria Vicedo-Cabrera Anna C. Gunz Éric Lavigne Piotr Wilk Tags: Review Source Type: research

A New Study Shows How Seriously Air Pollution Can Affect Your Heartbeat
For China’s 1.4 billion people, the simple act of breathing has long been something of a risk. Living in the ninth-dirtiest country in the world in terms of air quality, China’s residents lose an average of 2.6 years of life per capita due to atmospheric pollution alone. The greatest risk, of course, is pulmonary, with air pollution leading to shortness of breath, wheezing, coughing, asthma episodes, and chest pain. But pollution affects the heart too; the U.S. Environmental Protection Agency reports that exposure to fine-particulate matter as well as to nitrogen oxides alone can lead to premature aging in bloo...
Source: TIME: Health - May 1, 2023 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized climate change Climate Is Everything Environment healthscienceclimate Source Type: news

Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age
CONCLUSION: aTRH was significantly associated with an increased risk of CVD and this association was modified by both sex and age. Further studies are warranted to test these mechanisms.PMID:37274374 | PMC:PMC10237003 | DOI:10.4330/wjc.v15.i5.262
Source: World Journal of Cardiology - June 5, 2023 Category: Cardiology Authors: Julianne Theresa Nelson Longjian Liu Source Type: research

Association of preoperative clinical frailty and clinical outcomes in elderly patients with stable coronary artery disease after percutaneous coronary intervention
AbstractThere are few reports on the long-term clinical outcome after percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD) complicated with frailty. This novel study investigated the association between pre-PCI frailty and long-term clinical outcomes in elderly patients aged 65  years or older with stable CAD who underwent elective PCI. We assessed 239 consecutive patients aged 65 years or older with stable CAD who underwent successful elective PCI at Kagoshima City Hospital between January 1st, 2017 and December 31st, 2020. Frailty was retrospectively assessed using the Canadian...
Source: Heart and Vessels - June 7, 2023 Category: Cardiology Source Type: research

Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age
CONCLUSION: aTRH was significantly associated with an increased risk of CVD and this association was modified by both sex and age. Further studies are warranted to test these mechanisms.PMID:37274374 | PMC:PMC10237003 | DOI:10.4330/wjc.v15.i5.262
Source: World Journal of Cardiology - June 5, 2023 Category: Cardiology Authors: Julianne Theresa Nelson Longjian Liu Source Type: research

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