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Condition: Heart Failure

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Total 253 results found since Jan 2013.

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling
In conclusion, elabela antagonizes Ang II-mediated promotion of CMVECs ferroptosis, adverse myocardial remodeling, fibrosis and heart dysfunction through modulating the IL-6/STAT3/GPX4 signaling pathway. Targeting elabela-APJ axis serves as a novel strategy for hypertensive heart diseases.PMID:35122997 | DOI:10.1016/j.freeradbiomed.2022.01.020
Source: Free Radical Biology and Medicine - February 5, 2022 Category: Biology Authors: Zhenzhou Zhang Jianqiong Tang Jiawei Song Mengshi Xie Ying Liu Zhaojie Dong Xiaoyan Liu Xueting Li Miwen Zhang Yihang Chen Hongyu Shi Jiuchang Zhong Source Type: research

Molecules, Vol. 27, Pages 1346: Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin
g-Han Lee Acute β-adrenergic stimulation contributes to heart failure. Here, we investigated the role of p53 in isoproterenol (ISO)-mediated metabolic and oxidative stress effects on cardiomyocytes and explored the direct protective effects offered by the antioxidant nutraceutical curcumin. Differentiated H9C2 rat cardiomyocytes treated with ISO were assayed for glucose uptake, lactate release, and mitochondrial reactive oxygen species (ROS) generation. Survival was assessed by sulforhodamine B assays. Cardiomyocytes showed significantly decreased glucose uptake and lactate release, as well as increased ce...
Source: Molecules - February 16, 2022 Category: Chemistry Authors: Jin Hee Lee Da Hae Kim MinA Kim Kyung-Ho Jung Kyung-Han Lee Tags: Article Source Type: research

GSK-3 β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation
CONCLUSIONS: We identified a novel mechanism by which GSK-3β localizes to the myofilament to modulate LDA. Importantly, z-disc GSK-3β levels were reduced in patients with heart failure, indicating z-disc localized GSK-3β is a possible therapeutic target to restore the Frank-Starling mechanism in patients with heart failure.PMID:35168370 | DOI:10.1161/CIRCRESAHA.121.319491
Source: Circulation Research - February 16, 2022 Category: Cardiology Authors: Marisa J Stachowski-Doll Maria Papadaki Thomas G Martin Weikang Ma Henry M Gong Stephanie Shao Shi Shen Nitha Aima Muntu Mohit Kumar Edith Perez Jody L Martin Christine S Moravec Sakthivel Sadayappan Stuart G Campbell Thomas Irving Jonathan A Kirk Source Type: research

Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure
Biomaterials. 2022 Feb 18;283:121421. doi: 10.1016/j.biomaterials.2022.121421. Online ahead of print.ABSTRACTAutologous cardiac cell therapy is a promising treatment for combating the right ventricular heart failure (RVHF) that can occur in patients with congenital heart disease (CHD). However, autologous cell therapies suffer from low cell retention following injection and patient-to-patient variability in cell quality. Here, we demonstrate how computational methods can be used to identify mechanisms of cardiac-derived c-Kit+ cell (CPC) reparative capacity and how biomaterials can be designed to improve cardiac patch perf...
Source: Biomaterials - February 26, 2022 Category: Materials Science Authors: Benjamin W Streeter Milton E Brown Preety Shakya Hyun-Ji Park Jichuan Qiu Younan Xia Michael E Davis Source Type: research

Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice
Biochem Biophys Res Commun. 2022 Mar 9;604:137-143. doi: 10.1016/j.bbrc.2022.02.064. Online ahead of print.ABSTRACTRho kinase (ROCK) is implicated in the development of pulmonary arterial hypertension (PAH) in which abnormal pulmonary vascular smooth muscle (VSM) contractility and remodeling lead to right heart failure. Pharmacologic ROCK inhibitors block experimental pulmonary hypertension (PH) development in rodents but can have off-target effects and do not distinguish between the two ROCK forms, ROCK1 and ROCK2, encoded by separate genes. An earlier study using gene knock out (KO) in mice indicated that VSM ROCK2 is re...
Source: Biochemical and Biophysical Research communications - March 18, 2022 Category: Biochemistry Authors: Krishna C Penumatsa Adit A Singhal Rod R Warburton Michael D Bear Chinmayee D Bhedi Sabina Nasirova Jamie L Wilson Guanming Qi Ioana R Preston Nicholas S Hill Barry L Fanburg Young-Bum Kim Deniz Toksoz Source Type: research

Periplocymarin alleviates pathological cardiac hypertrophy via inhibiting the JAK2/STAT3 signalling pathway
J Cell Mol Med. 2022 Apr 1. doi: 10.1111/jcmm.17267. Online ahead of print.ABSTRACTPathological cardiac hypertrophy is the most important risk factor for developing chronic heart failure. Therefore, the discovery of novel agents for treating pathological cardiac hypertrophy remains urgent. In the present study, we examined the therapeutic effect and mechanism of periplocymarin (PM)-mediated protection against pathological cardiac hypertrophy using angiotensinII (AngII)-stimulated cardiac hypertrophy in H9c2 cells and transverse aortic constriction (TAC)-induced cardiac hypertrophy in mice. In vitro, PM treatment significan...
Source: J Cell Mol Med - April 2, 2022 Category: Molecular Biology Authors: Cai-Lian Fan Sui Liang Meng-Nan Ye Wan-Jun Cai Miao Chen Yun-Long Hou Jun Guo Yi Dai Source Type: research

Dapagliflozin protects against doxorubicin-induced cardiotoxicity by restoring STAT3
Arch Toxicol. 2022 Apr 19. doi: 10.1007/s00204-022-03298-y. Online ahead of print.ABSTRACTDoxorubicin (Dox), an effective therapy in different types of cancer, is known to exhibit cardiotoxic effects. Despite previous studies indicating the benefits of dapagliflozin (DAPA) in patients experiencing heart failure, it remains uncertain whether DAPA exerts a protective effect on Dox-induced cardiac dysfunction. Signal transducer and activator of transcription 3 (STAT3) participates in various mechanisms of cardioprotection. Herein, we aimed to investigate the effects of DAPA on Dox-induced cardiotoxicity and the role of STAT3....
Source: Archives of Toxicology - April 19, 2022 Category: Toxicology Authors: Wei-Ting Chang Jhih-Yuan Shih Yu-Wen Lin Zhih-Cherng Chen Wei-Chih Kan Tsung-Hsien Lin Chon-Seng Hong Source Type: research

CXCL10 is a novel anti ‐angiogenic factor downstream of p53 in cardiomyocytes
The conditioned media from p53-expressing cardiomyocytes decreased the tube formation of Rat Aortic Endothelial Cells. The blockade of CXCR3, a receptor of CXCL10, restored the angiogenic activity of the conditioned media from p53-expressing cardiomyocytes. AbstractTumor suppressor protein p53 plays crucial roles in the onset of heart failure. p53 activation results in cardiac dysfunction, at least partially by suppressing angiogenesis. Though p53  has been reported to reduce VEGF production by inhibiting hypoxia-inducible factor, the anti-angiogenic property of p53 remains to be fully elucidated in cardiomyocytes. To ex...
Source: Physiological Reports - May 11, 2022 Category: Physiology Authors: Tri Wahyuni, Shota Tanaka, Ryuta Igarashi, Yoshiaki Miyake, Ayaha Yamamoto, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Shota Suzuki, Kosei Yokota, Yoshiaki Okada, Makiko Maeda, Masanori Obana, Yasushi Fujio Tags: ORIGINAL ARTICLE Source Type: research