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Quality improvement and practice-based research in neurology using the electronic medical record
We describe quality improvement and practice-based research using the electronic medical record (EMR) in a community health system–based department of neurology. Our care transformation initiative targets 10 neurologic disorders (brain tumors, epilepsy, migraine, memory disorders, mild traumatic brain injury, multiple sclerosis, neuropathy, Parkinson disease, restless legs syndrome, and stroke) and brain health (risk assessments and interventions to prevent Alzheimer disease and related disorders in targeted populations). Our informatics methods include building and implementing structured clinical documentation supp...
Source: Nature Clinical Practice - October 12, 2015 Category: Neurology Authors: Maraganore, D. M., Frigerio, R., Kazmi, N., Meyers, S. L., Sefa, M., Walters, S. A., Silverstein, J. C. Tags: Eye on Practice Source Type: research
3293660 Woman who thought she'd simply bumped her head is told she has FIVE brain tumours - and needs half her skull removed
Katherine Dance, 42, from Binfield, Berkshire, had an operation to remove the five tumours - which revealed one was cancerous. She had a stroke afterwards, leaving her unable to walk or talk.
Source: the Mail online | Health - October 28, 2015 Category: Consumer Health News Source Type: news
Katherine Dance has FIVE brain tumours and needs half her skull removed
Katherine Dance, 42, from Binfield, Berkshire, had an operation to remove the five tumours - which revealed one was cancerous. She had a stroke afterwards, leaving her unable to walk or talk.
Source: the Mail online | Health - October 28, 2015 Category: Consumer Health News Source Type: news
MMP‐9 in Translation: From Molecule to Brain Physiology, Pathology and Therapy
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 3, 2015 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Review Source Type: research
Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability
Publication date: 15 January 2016 Source:NeuroImage, Volume 125 Author(s): Anna K. Heye, Michael J. Thrippleton, Paul A. Armitage, Maria del C. Valdés Hernández, Stephen D. Makin, Andreas Glatz, Eleni Sakka, Joanna M. Wardlaw There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a pathophysiological component of several diseases, including cerebral small vessel disease and some dementias. Dynamic contrast-enhanced MRI (DCE-MRI) combined with tracer kinetic modelling is widely used for assessing permeability and perfusion in brain tumours and body tissues where contrast agents readily acc...
Source: NeuroImage - November 12, 2015 Category: Neuroscience Source Type: research
Pediatric rehabilitation: trends in length of stay.
Authors: Kim CT, Greenberg J, Kim H
Abstract
Length of stay (LOS) is one of the most important pieces of data used to measure clinical rehabilitation outcomes, but there is a paucity of LOS data regarding pediatric acute rehabilitation. The purpose of this study was to predict LOS based on admission diagnosis to an acute pediatric inpatient rehabilitation unit. The hypothesis was that LOS will vary according to admission diagnosis. One thousand one hundred forty-five patients were admitted to our acute inpatient rehabilitation unit from January 1, 2000 to December 31, 2007. Common admission impairment groups were o...
Source: Journal of Pediatric Rehabilitation Medicine - November 19, 2015 Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research
Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection.
Abstract
The neuroimmune system represents a dense network of biochemical signals associated with neurotransmitters, neuropeptides, neurohormones, cytokines, chemokines, and growth factors synthesized in neurons, glial cells and immune cells, to maintain systemic homeostasis. Endogenous and/or exogenous, noxious stimuli in any tissue are captured by sensor cells to inform the brain; likewise, signals originating at the central nervous system (CNS) level are transmitted to peripheral immune effectors which react to central stimuli. This multidirectional information system makes it possible for the CNS to respond to...
Source: Current Pharmaceutical Design - December 9, 2015 Category: Drugs & Pharmacology Authors: Cacabelos R, Torrellas C, Fernández-Novoa L, Aliev G Tags: Curr Pharm Des Source Type: research
Small Peptide and Protein-based Molecular Probes for Imaging Neurological Diseases.
Abstract
Neurologic disorders are prevalent diseases in the population and represent a major cause of death and disability. Despite the advances made during recent decades, the early diagnosis of these diseases remains a challenge. Determining the pathophysiology of such disorders is also challenging and is a requirement for the development of new drugs and treatments. Molecular neuroimaging studies can help fill these gaps in knowledge by providing clinicians with the tools necessary to diagnose and monitor treatment response and by providing data to help researchers understand the mechanisms of disease. Molecula...
Source: Current Protein and Peptide Science - January 1, 2016 Category: Biochemistry Authors: Venturin GT, Cheng Z Tags: Curr Protein Pept Sci Source Type: research
TAT-HSA-α-MSH fusion protein with extended half-life inhibits tumor necrosis factor-α in brain inflammation of mice.
Abstract
Neuroinflammation constitutes a principal process involved in the progression of various central nervous system (CNS) disorders, including Parkinson's disease, Alzheimer's disease, ischemic stroke, and traumatic brain injury. The safety and efficacy of potential neuroprotective therapeutic agents is controversial and limited. Alpha-melanocyte-stimulating hormone (α-MSH) as a tridecapeptide derived from pro-opiomelanocortin displays potent anti-inflammatory and protective effects with a wide therapeutic window in brain damage. However, it is difficult to deliver effective concentrations of α-MSH into bra...
Source: Applied Microbiology and Biotechnology - January 27, 2016 Category: Microbiology Authors: Wang M, Zhi D, Wang H, Ru Y, Ren H, Wang N, Liu Y, Li Y, Li H Tags: Appl Microbiol Biotechnol Source Type: research
Low Back Pain Caused by Superior Cluneal Nerve Entrapment Neuropathy in Patients with Parkinson Disease
In patients with Parkinson disease (PD), postural abnormalities and increased muscle tonus lead to musculoskeletal problems. The incidence of such problems was significantly higher in patients with PD than in an age-matched control group comprising patients with stroke and brain tumor.1 Low back pain (LBP) in particular was reported more frequently by patients with PD; in approximately 50%, it negatively affected their quality of life and activities of daily living (ADL).1-4 It is difficult to treat LBP in patients with PD,5-8 and the results of surgery to address their spinal diseases are unsatisfactory.
Source: World Neurosurgery - December 14, 2015 Category: Neurosurgery Authors: Naotaka Iwamoto, Toyohiko Isu, Kyongsong Kim, Yasuhiro Chiba, Rinko Kokubo, Daijiro Morimoto, Shinichi Shirai, Kazuyoshi Yamazaki, Masanori Isobe Tags: Technical Note Source Type: research
Mild Sedation Exacerbates or Unmasks Focal Neurologic Dysfunction in Neurosurgical Patients with Supratentorial Brain Mass Lesions in a Drug-specific Manner
Conclusions Midazolam and propofol augmented or revealed neurologic dysfunction more frequently than fentanyl and dexmedetomidine at equivalent sedation levels. Patients with high-grade gliomas were more susceptible than those with low-grade gliomas.
Source: Anesthesiology - February 17, 2016 Category: Anesthesiology Source Type: research
Challenges in the pharmacological management of epilepsy and its causes in the elderly.
Publication date: Available online 16 February 2016 Source:Pharmacological Research Author(s): Edoardo Ferlazzo, Chiara Sueri, Sara Gasparini, Umberto Aguglia Epilepsy represents the third most common neurological disorders in the elderly after cerebrovascular disorders and dementias. The incidence of new-onset epilepsy peaks in this age group. The most peculiar aetiologies of late-onset epilepsy are stroke, dementia, and brain tumours. However, aetiology remains unknown in about half of the patients. Diagnosis of epilepsy may be challenging due to the frequent absence of ocular witnesses and the high prevalence of s...
Source: Pharmacological Research - February 17, 2016 Category: Drugs & Pharmacology Source Type: research
Challenges in the pharmacological management of epilepsy and its causes in the elderly
Publication date: April 2016 Source:Pharmacological Research, Volume 106 Author(s): Edoardo Ferlazzo, Chiara Sueri, Sara Gasparini, Umberto Aguglia Epilepsy represents the third most common neurological disorders in the elderly after cerebrovascular disorders and dementias. The incidence of new-onset epilepsy peaks in this age group. The most peculiar aetiologies of late-onset epilepsy are stroke, dementia, and brain tumours. However, aetiology remains unknown in about half of the patients. Diagnosis of epilepsy may be challenging due to the frequent absence of ocular witnesses and the high prevalence of seizure-mimi...
Source: Pharmacological Research - February 25, 2016 Category: Drugs & Pharmacology Source Type: research
Mapping neuroplastic potential in brain-damaged patients
It is increasingly acknowledged that the brain is highly plastic. However, the anatomic factors governing the potential for neuroplasticity have hardly been investigated. To bridge this knowledge gap, we generated a probabilistic atlas of functional plasticity derived from both anatomic magnetic resonance imaging results and intraoperative mapping data on 231 patients having undergone surgery for diffuse, low-grade glioma. The atlas includes detailed level of confidence information and is supplemented with a series of comprehensive, connectivity-based cluster analyses. Our results show that cortical plasticity is generally...
Source: Brain - February 25, 2016 Category: Neurology Authors: Herbet, G., Maheu, M., Costi, E., Lafargue, G., Duffau, H. Tags: CNS Injury and Stroke Original Articles Source Type: research
Chapter 17 Rehabilitation of patients with glioma
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 134 Author(s): Mary Vargo, Roger Henriksson, Pär Salander Disabling sequelae occur in a majority of patients diagnosed with brain tumor, including glioma, such as cognitive deficits, weakness, and visual perceptual changes. Often, multiple impairments are present concurrently. Healthcare staff must be aware of the “biographic disruption” the patient with glioma has experienced. While prognostic considerations factor into rehabilitation goals and expectations, regardless of prognosis the treatment team must offer cohesive support, facilitating ho...
Source: Handbook of Clinical Neurology - March 4, 2016 Category: Neurology Source Type: research
