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Total 515 results found since Jan 2013.

Janssen Announces U.S. FDA Approval of INVEGA HAFYERA ™(6-month paliperidone palmitate), First and Only Twice-Yearly Treatment for Adults with Schizophrenia
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA approval of INVEGA ...
Source: Johnson and Johnson - September 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Major adverse cardiovascular and limb events in patients with diabetes treated with GLP-1 receptor agonists vs DPP-4 inhibitors
Conclusions/interpretationIn individuals with diabetes, the use of GLP1RAs was associated with significantly lower risks of major adverse limb events when compared with the use of DPP4is. The reduction in risk was driven largely by reduced rate of amputations. Moreover, treatment with GLP1RAs was also associated with lower risks of cardiovascular death, non-fatal stroke, non-fatal myocardial infarction and death from any cause. However, some unexplored confounding factors may exist in this observation study and future large-scale randomised controlled trials are needed.Graphical abstract
Source: Diabetologia - August 24, 2021 Category: Endocrinology Source Type: research

Real-World Outcomes of On- vs Off-Pump Coronary Bypass Surgery: Result from Korean Nationwide Cohort
CONCLUSIONS: In this contemporary, nationwide, clinical practice claim registry, off-pump CABG was associated with higher long-term risks of mortality, MI, and repeat revascularization than on-pump CABG.PMID:34400133 | DOI:10.1016/j.athoracsur.2021.07.035
Source: The Annals of Thoracic Surgery - August 17, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Sung Jun Park Ae Jung Jo Hyo Jeong Kim Songhee Cho Min Jung Ko Sung Cheol Yun Duk-Woo Park Joon Bum Kim Source Type: research

Risk of Cardiovascular Conditions in Patients with Chronic Hypoparathyroidism: A Retrospective Cohort Study
ConclusionsThis large retrospective cohort study showed that chronic hypoparathyroidism was associated with increased risk of incident cardiovascular conditions and arrhythmias. Results should be evaluated in light of limitations inherent to claims database analyses. Further studies are warranted to investigate reasons for these risks and to develop strategies for reducing cardiovascular conditions in patients with chronic hypoparathyroidism.
Source: Advances in Therapy - June 24, 2021 Category: Drugs & Pharmacology Source Type: research

Non-Persistence With Antiplatelet Medications Among Older Patients With Peripheral Arterial Disease
Conclusion: In patients with an increased probability of non-persistence, an increased attention should be paid to improvement of persistence.
Source: Frontiers in Pharmacology - May 19, 2021 Category: Drugs & Pharmacology Source Type: research

In-hospital Complications Are More Likely to Occur After Reverse Shoulder Arthroplasty Than After Locked Plating for Proximal Humeral Fractures
CONCLUSION: The increased in-hospital risk for major adverse events and surgical complications may moderate the enthusiasm associated with RTSA for proximal humeral fractures in patients 65 years and older. Treatment decisions should be based on individual risk estimation to avoid potential harmful events. Future studies must include long-term outcomes and quality of life to enlighten these findings in a broader context.LEVEL OF EVIDENCE: Level III, therapeutic study.PMID:33938479 | DOI:10.1097/CORR.0000000000001776
Source: Clinical Orthopaedics and Related Research - May 3, 2021 Category: Orthopaedics Authors: Jeanette K öppe Josef Stolberg-Stolberg Robert Rischen Andreas Faldum Michael J Raschke J Christoph Katthagen Source Type: research

Comparative Effectiveness and Safety of Prasugrel versus Ticagrelor following Percutaneous Coronary Intervention: An Observational Study
ConclusionWhen compared with ticagrelor, prasugrel use following PCI for ACS was associated with a lower risk of death, MI, or stroke, as well as a reduced risk of major bleeding.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 1, 2021 Category: Drugs & Pharmacology Authors: Nicholas Belviso, Herbert D. Aronow, Richard Wyss, Marilyn Barbour, Yichi Zhang, Xuerong Wen, Stephen Kogut Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Cardiovascular Risk of Concomitant Use of Atypical Antipsychotics and Stimulants Among Commercially Insured Youth in the United States
Conclusions: Severe cardiovascular events are rare. Concomitant stimulant/AAP use elevates the risk of less severe cardiovascular events. Periodic heart rate or blood pressure monitoring for youth on stimulant/AAP treatment may be warranted.
Source: Frontiers in Psychiatry - April 29, 2021 Category: Psychiatry Source Type: research

Examining elevated blood pressure and the effects of diabetes self-management education on blood pressure among a sample of Marshallese with type 2 diabetes in Arkansas
ConclusionThis study is the first to document the prevalence of diagnosed hypertension and undiagnosed high blood pressure, as well as the effects of DSME on blood pressure among a sample of Marshallese adults with T2DM.
Source: PLoS One - April 22, 2021 Category: Biomedical Science Authors: Pearl A. McElfish Source Type: research

How Does SARS-CoV-2 Infection Affect Survival of Emergency Cardiovascular Patients? A Cohort Study From a German Insurance Claims Database
CONCLUSION: This retrospective analysis of claims data has provided hints of an association between the COVID-19 pandemic and increased in hospital mortality in patients with acute stroke. Furthermore, confirmed SARS-CoV-2 infection was associated with increased mortality in patients with stroke, TIA, and ALI. Future studies are urgently needed to better understand the underlying mechanism and relationship between the new coronavirus and acute stroke.PMID:33824066 | DOI:10.1016/j.ejvs.2021.03.006
Source: PubMed: Eur J Vasc Endovasc ... - April 7, 2021 Category: Surgery Authors: Christian-Alexander Behrendt Moritz Seiffert Christian Gerloff Helmut L'Hoest Laura Acar G ötz Thomalla Source Type: research