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Long-term exposure to ozone and cardiovascular mortality in a large Chinese cohort
CONCLUSIONS: We observed the association between long-term exposure to high O3 concentrations and cause-specific CVD mortality in China, independent of PM2.5 and other CVD risk factors. This suggested an urgent need to control O3 pollution, especially in developing countries.PMID:35605364 | DOI:10.1016/j.envint.2022.107280
Source: Environment International - May 23, 2022 Category: Environmental Health Authors: Shudan Liu Yi Zhang Runmei Ma Xiaofei Liu Jingyuan Liang Hongbo Lin Peng Shen Jingyi Zhang Ping Lu Xun Tang Tiantian Li Pei Gao Source Type: research

Relationship of diabetes, heart failure, and N ‐terminal pro‐B‐type natriuretic peptide with cardiovascular outcomes in patients with atrial fibrillation
ConclusionsDiabetes and HF were independently associated with an increased risk of CV death/HHF in an unselected AF patient population, and NT-proBNP improved risk assessment. These findings suggest that AF patients with diabetes and/or HF should be managed not only for their risk of stroke and systemic embolic events but also for CV death/HHF.
Source: ESC Heart Failure - May 20, 2022 Category: Cardiology Authors: Felix Hofer, Ulrike Pailer, Patrick Sulzgruber, Christian Gerges, Max ‐Paul Winter, Robert P. Giugliano, Michael Gottsauner‐Wolf, Martin Hülsmann, Niema Kazem, Lorenz Koller, Robert Schönbauer, Alexander Niessner, Christian Hengstenberg, Tags: Original Article Source Type: research

Effects of ACE inhibitors and angiotensin receptor blockers: protocol for a UK cohort study using routinely collected electronic health records with validation against the ONTARGET trial
Introduction Cardiovascular disease is a leading cause of death globally, responsible for nearly 18 million deaths worldwide in 2017. Medications to reduce the risk of cardiovascular events are prescribed based on evidence from clinical trials which explore treatment effects in an indicated sample of the general population. However, these results may not be fully generalisable because of trial eligibility criteria that generally restrict to younger patients with fewer comorbidities. Therefore, evidence of effectiveness of medications for groups underrepresented in clinical trials such as those aged ≥75 years, from ethni...
Source: BMJ Open - March 8, 2022 Category: General Medicine Authors: Baptiste, P. J., Wong, A. Y. S., Schultze, A., Cunnington, M., Mann, J. F. E., Clase, C., Leyrat, C., Tomlinson, L. A., Wing, K. Tags: Open access, Epidemiology Source Type: research

Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records
Conclusion: Among individuals with obesity, the weight-loss group had a lower risk of coronary heart disease but not of stroke. Weight gain was associated with increased risk of CVD across BMI groups. See video abstract at, http://links.lww.com/EDE/B838.
Source: Epidemiology - August 3, 2021 Category: Epidemiology Tags: Chronic Diseases Source Type: research

Using electronic health records to develop and validate a machine-learning tool to predict type 2 diabetes outcomes: a study protocol
Introduction Type 2 diabetes mellitus (T2DM) is a major cause of blindness, kidney failure, myocardial infarction, stroke and lower limb amputation. We are still unable, however, to accurately predict or identify which patients are at a higher risk of deterioration. Most risk stratification tools do not account for novel factors such as sociodemographic determinants, self-management ability or access to healthcare. Additionally, most tools are based in clinical trials, with limited external generalisability. Objective The aim of this work is to design and validate a machine learning-based tool to identify patients with T2...
Source: BMJ Open - July 30, 2021 Category: General Medicine Authors: Neves, A. L., Pereira Rodrigues, P., Mulla, A., Glampson, B., Willis, T., Darzi, A., Mayer, E. Tags: Open access, Health informatics Source Type: research

Are Digital Health Services the Key to Bridging the Gap in Medication Adherence and Optimisation?
Strong adherence to medications for the secondary prevention of cardiovascular disease (CVD), (e.g., lipid-lowering therapy, antihypertensives, antiplatelets), can reduce the risk of adverse cardiovascular events such as myocardial infarction and stroke [1]. Yet, poor adherence rates to therapies of about 50% are common among patients with chronic diseases [2]. There are various reasons for this large gap which include poor patient health literacy and incomplete/out-dated medication lists in electronic health records.
Source: Heart, Lung and Circulation - May 5, 2021 Category: Cardiology Authors: Harry Klimis, Clara K. Chow Tags: Editorial Source Type: research

Incidence and Risk of Various Types of Arterial Thromboembolism in Patients With Cancer
CONCLUSION: In this observational study of an aggregated US patient population, those with newly diagnosed cancer had increased risk of ATE events. This risk was most elevated in a 330-day window around cancer diagnosis and was consistent across different types of ATE and cancer.PMID:33673912 | DOI:10.1016/j.mayocp.2020.05.045
Source: Clinical Colorectal Cancer - March 6, 2021 Category: Cancer & Oncology Authors: Jiasheng Wang Yeseong D Kim Chang H Kim Source Type: research

Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease
CONCLUSIONS: Long-term fine particulate matter exposure was associated with an increased risk of cardiovascular mortality among adults with chronic obstructive pulmonary disease. Current regulations may not sufficiently protect those with chronic obstructive pulmonary disease.PMID:33662228 | DOI:10.1164/rccm.202007-2901OC
Source: Am J Respir Crit Car... - March 4, 2021 Category: Intensive Care Authors: Stacey E Alexeeff Kamala Deosaransingh Noelle S Liao Stephen K Van Den Eeden Joel Schwartz Stephen Sidney Source Type: research

Obesity and mortality after the first ischemic stroke: Is obesity paradox real?
ConclusionOur study results support the obesity paradox in ischemic stroke patients as shown by a significantly decreased hazard ratio for one-year mortality among overweight and obese patients in comparison to non-overweight patients.
Source: PLoS One - February 10, 2021 Category: Biomedical Science Authors: Durgesh Chaudhary Source Type: research

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