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Evaluation of a Novel Adjuvanted Vaccine for Ultrashort Regimen Therapy of Artemisia Pollen-Induced Allergic Bronchial Asthma in a Mouse Model
Wormwood (Artemisia) pollen is among the top 10 aeroallergens globally that cause allergic rhinitis and bronchial asthma. Allergen-specific immunotherapy (ASIT) is the gold standard for treating patients with allergic rhinitis, conjunctivitis, and asthma. A significant disadvantage of today’s ASIT methods is the long duration of therapy and multiplicity of allergen administrations. The goal of this study was to undertake a pilot study in mice of a novel ultrashort vaccine immunotherapy regimen incorporating various adjuvants to assess its ability to treat allergic bronchial asthma caused by wormwood pollen.We evaluated i...
Source: Frontiers in Immunology - March 15, 2022 Category: Allergy & Immunology Source Type: research

Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy
Toll-like receptors (TLRs) are essential components of innate immunity and provide defensive inflammatory responses to invading pathogens. Located within the plasma membranes of cells and also intracellular endosomes, TLRs can detect a range of pathogen associated molecular patterns from bacteria, viruses and fungi. TLR activation on dendritic cells can propagate to an adaptive immune response, making them attractive targets for the development of both prophylactic and therapeutic vaccines. In contrast to conventional adjuvants such as aluminium salts, TLR agonists have a clear immunomodulatory profile that favours anti-al...
Source: Frontiers in Immunology - November 12, 2020 Category: Allergy & Immunology Source Type: research

New toxicity testing of PQ grass allergy immunotherapy to support product development
AbstractPQ Grass represents an allergen ‐specific immunotherapy for pre‐seasonal treatment of patients with seasonal allergic rhinitis (or rhinoconjunctivitis) with or without mild‐to‐moderate bronchial asthma. It consists of a native pollen extract for 13 grass species, chemically modified with glutaraldehyde, and adsorbed tol‐tyrosine in a microcrystalline form with addition of the adjuvant Monophosphoryl Lipid A (MPL®). Previous non ‐clinical safety testing, including rat repeat dose toxicity in adult and juvenile animals, rat reproductive toxicity and rabbit local tolerance studies showed no safety finding...
Source: Journal of Applied Toxicology - June 22, 2019 Category: Toxicology Authors: Paul Baldrick, James W. Hutchings, Matthew D. Heath, Murray A. Skinner, Tom Martin, Chris Gray Tags: RESEARCH ARTICLE Source Type: research

The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influen...
Source: Frontiers in cellular and infection microbiology - April 16, 2019 Category: Microbiology Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

Allergies: Can Too Much Hygiene Actually Harm Us?
It's that time of the year again. You step out of the house and your eyes itch, your nose starts running and your head feels like an empty balloon. Yes, it's allergy season. Even the resilient ones, give them enough time and eventually they will develop some form of allergic reaction. But what are allergies and why do so many people suffer from them? Allergies are a glitch in our immune system. The immune system is built to recognize and destroy pathogens -- potential threats like viruses and harmful bacteria. Unlike pathogens, allergens are substances that, despite being harmless to the body, still trigger a response f...
Source: Science - The Huffington Post - April 4, 2016 Category: Science Source Type: news

Neonatal vaccination with plasmid DNA encoding Cyn d 1 effectively prevents allergic responses in mice.
CONCLUSION: This study shows the prophylactic effects of DNA vaccine encoding Bermuda grass pollen allergen Cyn d 1 on specific IgE responses in neonatal mice. PMID: 24980227 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - May 1, 2014 Category: ENT & OMF Authors: Huang CF, Wu CC, Chu DM, Chang ZN, Chue FL, Peng HJ Tags: Am J Rhinol Allergy Source Type: research

Comparison of antiallergic effects of pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine in a murine model of allergic rhinitis
Conclusion and Clinical RelevanceBoth PV and PCV suppressed the allergen‐specific T helper 2 response and induced regulatory T cells in a murine model of allergic rhinitis. However, PV and PCV may activate Treg cells via different mechanisms. Level of EvidenceN/A. Laryngoscope, 2013
Source: The Laryngoscope - February 16, 2013 Category: ENT & OMF Authors: Boo‐Young Kim, Ji‐Hyeon Shin, Hyang Rim Park, Sung Won Kim, Soo Whan Kim Tags: Allergy/Rhinology Source Type: research