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Reversal of Olfactory Disturbance in Allergic Rhinitis Related to OMP Suppression by Intranasal Budesonide Treatment.
CONCLUSIONS: OD may be caused by olfactory epithelial damage and suppression of OMP expression in nasal allergic inflammation and could be reversed using an intranasal steroid. PMID: 31743968 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 20, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Implementation science into the public - pregnant women need to prenatal visit for allergy prevention?
Allergic diseases such as atopic dermatitis (AD), food allergy (FA), asthma and allergic rhinitis (AR) are common; according to a national birth cohort study in Japan, almost half of pregnant women reported a history of allergic disease.1 Given that genetic factors, including family history, are predictors of allergic diseases in offspring, we expect the birth of many infants who carry a high risk of developing allergies. Among allergy prevention strategies, the effectiveness of primary prevention of eczema in high-risk infants by the topical application of emollient during the neonatal period has been demonstrated in two ...
Source: Annals of Allergy, Asthma and Immunology - November 21, 2019 Category: Allergy & Immunology Authors: Kiwako Yamamoto-Hanada, John Ichiro Takayama, Mayako Saito-Abe, Masaki Futamura, Yukihiro Ohya Tags: Letters Source Type: research

ICON: Diagnosis and Management of Allergic Conjunctivitis.
Abstract Ocular allergy (OA), interchangeably known as allergic conjunctivitis, is a common immunological hypersensitivity disorder affecting up to 40% of the population. OA has been increasing in frequency with symptoms of itching, redness, and swelling that significantly impacts an individual's quality of life (QOL). OA is an often underdiagnosed and under-treated health problem as only 10% of patients with OA symptoms seek medical attention while the majority of patients manage with over the counter medications and complementary nonpharmacological remedies. The clinical course, duration, severity, and co-morbid...
Source: Annals of Allergy, Asthma and Immunology - November 19, 2019 Category: Allergy & Immunology Authors: Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P Tags: Ann Allergy Asthma Immunol Source Type: research

Prenatal visits for allergy prevention
Allergic diseases, such as atopic dermatitis, food allergy, asthma, and allergic rhinitis, are common; according to a national birth cohort study in Japan, almost half of pregnant women reported a history of allergic disease.1 Given that genetic factors, including family history, are predictors of allergic diseases in offspring, we expect the birth of many infants with a high risk of developing allergies. Among allergy prevention strategies, the effectiveness of primary prevention of eczema in high-risk infants by the topical application of emollient during the neonatal period has been demonstrated in 2 randomized controlled trials (RCTs).
Source: Annals of Allergy, Asthma and Immunology - November 21, 2019 Category: Allergy & Immunology Authors: Kiwako Yamamoto-Hanada, John Ichiro Takayama, Mayako Saito-Abe, Masaki Futamura, Yukihiro Ohya Tags: Letters Source Type: research

Ocular Symptoms Improvement from Intranasal Triamcinolone compared with Placebo and Intranasal Fluticasone Propionate: a meta-analysis.
CONCLUSION: The meta-analysis demonstrated the positive clinical improvements TAA has on total ocular allergy symptoms, especially tearing, in addition to its recognized nasal symptom efficacy in SAR. PMID: 32004698 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 27, 2020 Category: Allergy & Immunology Authors: Bielory L, Gross G, Letierce A, Melas-Melt L, Lucio L Tags: Ann Allergy Asthma Immunol Source Type: research

Evaluating the Immunoreactivity of Ailanthus Altissima (The Tree of Heaven) Pollen Extract in Atopic Patients.
This study revealed that some of A. altissima pollen proteins ranging from 10 to 70 kDa show IgE-reactivity in atopic patients and may play a role in their allergic reaction symptoms. PMID: 32372626 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - April 15, 2020 Category: Allergy & Immunology Authors: Samei A, Fallahpour M, Bolouri MR, Mahmoudi AR, Nasri F, Seif F, Khoshmirsafa M, Batooli H, Shekarabi M, Falak R Tags: Iran J Allergy Asthma Immunol Source Type: research

Chronic Rhinosinusitis and Allergy: Increased Allergen Sensitization Versus Real Allergic Rhinitis Multimorbidity: a Systematic Review
The objective of this article is to provide a recent update of the association between allergic inflammation and chronic rhinosinusitis. The systematic approach of this review article critically evaluates the literature published over the past few years and summarizes the specific pathophysiologic pathway of chronic sinonasal inflammation that has been postulated.Recent FindingsFrom a systematic search of the Ovid Medline and Embase, 11 studies were included in a qualitative analysis of the association between systemic allergy and chronic rhinosinusitis (CRS). Of the 11 studies, four showed an association, three were incon...
Source: Current Allergy and Asthma Reports - May 18, 2020 Category: Allergy & Immunology Source Type: research

Pharmacotherapy in allergy medicine: from ‘ipse dixit’ to the evidence-based medicine
Purpose of review The aim of the article is to examine the contributions made in recent years by evidence-based medicine to the understanding, positioning, and use of drugs for the treatment of the main allergic conditions. Recent findings Several antiasthmatic drugs have been reappraised for their efficacy characteristics and drug interactions in Cochrane reviews. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines have been reformulated in evidence-based medicine (EBM) terms in 2017; over these years, new point of care instruments contributed to the approximation of the guidelines to real life by drawin...
Source: Current Opinion in Allergy and Clinical Immunology - June 25, 2020 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Biologics and Allergy Immunotherapy in the Treatment of Allergic Diseases
Allergic diseases represent some of the most chronic and costly chronic conditions. Medical management may require long-term pharmacotherapy, which is often associated with poor adherence. Although medications provide symptomatic control, they do not modify the allergic disease. Patients may prefer disease-modifying treatments that provide lasting benefits after discontinuation. To date, allergy immunotherapy is the only proved disease modification therapy associated with lasting benefits after discontinuation. However, allergy immunotherapy safety and efficacy has only been established in allergic rhinitis, mild to modera...
Source: Immunology and Allergy Clinics of North America - September 11, 2020 Category: Allergy & Immunology Authors: Linda Cox Source Type: research

Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma.
CONCLUSIONS: The results of our study suggest that iTr35 cells may play an important role in preventing Th2 responses to allergens by secreting IL-35 and that iTr35 cells may be a potential new immune regulator of allergic asthma. PMID: 32935493 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Trial Confirms Benefit of SLIT for Dust Mite Allergy Trial Confirms Benefit of SLIT for Dust Mite Allergy
A sublingual tablet containing house dust mite (HDM) extract is effective for reducing allergic rhinitis symptoms (AR), a new phase-3 trial shows.Reuters Health Information
Source: Medscape Allergy Headlines - September 17, 2020 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Allergic rhinits: impact on quality of life of adolescents.
Authors: Rosario CS, Murrieta-Aguttes M, Rosario NA Abstract Summary: Adolescence is one of the most rapid phases of human development, in which biological maturity precedes psychosocial maturity. Rhinoconjunctivitis (ARC) is present in around 15 percent of 13-14-year-old children, which indicates a higher prevalence when compared with 6-7-year-old children (8.5 percent). During childhood (0-10 years) prevalence of Allergic Rhinitis (AR) is higher among males compared to females. Quite the reverse, during adolescence (11-17 years) females display higher prevalence of AR compared to males. However, when they reach a...
Source: European Annals of Allergy and Clinical Immunology - November 17, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Rhinitis as the Presenting Symptom of Pineal Region Epidermoid Tumor: A Case Report.
We described a 34-year-old man who came to our allergy clinic with a chief complaint of clear rhinorrhea from his left nostril with more than four years of duration. Onlyhypertrophy of left inferior concha was found in the clinical examination. His rhinorrhea aggravated when bending forward. So we were suspicious of CSF rhinorrhea. MRI was done for him and demonstrated a large tumor in the pineal region. The patient underwent surgery with resection of the mass via an infratentorial-supracerebellar approach. This case showed the role of maintaining differential diagnosis for a common complaint; rhinitis which is seen as usu...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Joudi M, Eshaghi Ghalibaf MH, Ghorbanzadeh A, Zabihyan S, Moazzen N, Khoshkhui M Tags: Iran J Allergy Asthma Immunol Source Type: research

Grass Pollen Allergy as an Anaphylaxis Co-factor during Peanut Oral Immunotherapy
Grass pollen allergy, typically associated with non-life-threatening symptoms such as rhinoconjunctivitis is one of the most common allergies worldwide.1 Rarely, anaphylaxis occurs after grass pollen exposure in children.2 Oral immunotherapy (OIT) for the treatment of food allergy has been gaining popularity over the last decade as evidence on methodology, effectiveness and safety has progressed.3 4 Studies have shown that peanut-allergic patients on OIT with seasonal allergic rhinitis experience dose-related adverse events more frequently with seasonal patterns.
Source: Annals of Allergy, Asthma and Immunology - May 7, 2021 Category: Allergy & Immunology Authors: Gilbert T Chua, Edmond S. Chan, Lianne Soller, Scott B. Cameron Source Type: research

Psychosocial impact of ocular surface allergic inflammatory disorders
This article reviews the psychosocial impact of ocular surface allergic inflammatory disorders (namely seasonal allergic conjunctivitis, ocular allergy, perennial allergic conjunctivitis, and atopic keratoconjunctivitis) on adult and pediatric populations. Recent findings Despite the perception that allergic conjunctivitis is a trivial condition, it imposes a burden on numerous psychosocial aspects of life for adolescents and adults. Several questionnaires specific to rhinoconjunctivitis have been found to be effective tools at gauging quality of life (QoL) and communicating impairments in specific behavioral domain...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: EYE ALLERGY: Edited by Leonard Bielory and Abraham Solomon Source Type: research