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The role of epigenetics in allergy and asthma development
Purpose of review Epigenetic mechanisms are known to play a crucial role in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, food allergy, and other allergic disorders, especially through mediating the effects of the environmental factors, well recognized allergy-risk modifiers. The aim of this work was to provide a concise but comprehensive review of the recent progress in the epigenetics of allergic diseases. Recent findings Recent few years have substantially expanded our knowledge on the role of epigenetics in the pathogenesis and clinical picture of allergies. Specifically, it has been shown that...
Source: Current Opinion in Allergy and Clinical Immunology - January 3, 2020 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research

Comparison of sIgG4 levels among allergic patients and patients during ASIT
Currently, the only systemic treatment of allergic diseases is allergen specific immunotherapy (ASIT). The therapy duration may take up to 3 years and in some cases ASIT may not be effective. The elevated levels of allergen-specific IgG4 (sIgG4) is associated with the effectiveness of the treatment.The aim of the study was to detect the differences of sIgG4 levels among allergic patients and patients during ASIT.1000 samples from patients aged 6 months to 17 years from the Moscow region who were suspected of having allergic diseases such as pollinosis, allergic rhinitis, atopic dermatitis and bronchial asthma were included...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Feyzkhanova, G., Smoldovskaya, O., Voloshin, S., Pavlushkina, L., Antonova, E., Filatova, T., Zasedatelev, A., Rubina, A. Tags: Allergy and immunology Source Type: research

AirRater Tasmania: Using Smartphone Technology to Understand Local Environmental Drivers of Symptoms in People with Asthma and Allergic Rhinitis
The purpose of this study was to use a novel smartphone based application, AirRater, to identify the most important local environmental factors associated with symptoms in people with allergic rhinitis and asthma, in Tasmania, Australia.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Fay Johnston, Amanda Wheeler, Grant Williamson, Penelope Jones, Iain S. Koolhof Source Type: research

Prevalence of Long Term Opioid Use in Patients with Asthma and Allergic Rhinitis
Opioids are known to increase histamine release from mast cells involved in asthma and allergic rhinitis. Opioids stimulate T cell responses via immune system polarization toward IgE promoting TH2 cytokine pathway.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Roshni Naik, Grant Goodrich, Taha Al-Shaikhly, Rauno Joks Source Type: research

The Florence Statement on Triclosan and Triclocarban
Author Affiliations open 1Biodesign Center for Environmental Security, Arizona State University, Tempe, Arizona, USA 2Green Science Policy Institute, Berkeley, California, USA 3Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA 4Environmental Working Group, Washington, District of Columbia, USA 5Department of Civil, Environmental, and Geo-Engineering, University of Minnesota, Minneapolis, Minnesota, USA 6Medical University of South Carolina, Department of Public Health Sciences, Charleston, South Carolina, USA 7Health Research Communicati...
Source: EHP Research - June 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research

Associations between Unconventional Natural Gas Development and Nasal and Sinus, Migraine Headache, and Fatigue Symptoms in Pennsylvania
Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample. Citation: Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189–197; http://dx.doi.org/10.1289/EHP281 Address correspondence to B.S. Schwartz, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room W7041, Baltimore, MD 21205 USA. Teleph...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

Air Quality and Climate Change: A Delicate Balance
Background image: © Elenamiv/Shutterstock John H. Tibbetts, based in Charleston, SC, is former editor of Coastal Heritage, the magazine of the South Carolina Sea Grant Consortium. About This Article open Citation: Tibbetts JH. 2015. Air quality and climate change: a delicate balance. Environ Health Perspect 123:A148–A153; http://dx.doi.org/10.1289/ehp.123-A148 News Topics: Air Pollution, Allergies, Asthma, Cardiovascular Health, Climate Change, Combustion Emissions, Dust, Natural Disasters, Ozone, Particulate Matter (PM), Pollen, Mold and Mycotoxins, Respiratory Health, Temperature, Weather Processes Published: 1 Jun...
Source: EHP Research - June 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Air Pollution Allergies Asthma Cardiovascular Health Climate Change Combustion Emissions Dust June 2015 Mold and Mycotoxins Natural Disasters Ozone Particulate Matter (PM) Pollen Respiratory Health Tem Source Type: research

Links between hay fever, asthma and prostate cancer inconclusive
Conclusion The researchers' suggestion that this research is "hypothesis generating" is the most apt. It shows a possible link between immune profiles and prostate cancer, but doesn't prove it or explain the underlying reasons for any such link. This single study does not provide solid evidence that asthma or hay fever would have any influence on a man's risk of developing prostate cancer or dying from it, particularly when you consider the uncertain statistical significance of several of the findings. Links suggesting asthma may be associated with a lower risk of total or lethal prostate cancer were all only of...
Source: NHS News Feed - May 20, 2015 Category: Consumer Health News Tags: Cancer Heart/lungs Source Type: news

Drowsiness and motor responses to consecutive daily doses of promethazine and loratadine
Nearly two-thirds of allergy sufferers do not consult their doctor about their condition, instead choosing to self-medicate (Walls et al., 2005). Over-the-counter treatment options for allergic reactions often include an antihistamine or inhaled corticosteroid. As antihistamines are often employed to treat persistent conditions such as seasonal allergic rhinitis, self-medicated drug use may continue for days, weeks and even months at a time (Layton et al., 2009, 2011).
Source: Clinical Neurophysiology - April 10, 2014 Category: Neuroscience Authors: Lyndsee Baumann-Birkbeck, Gary D. Grant, Shailendra Anoopkumar-Dukie, Justin J. Kavanagh Source Type: research

Complementary and Integrative Treatments: Allergy
This article reviews AR and some of the more common therapies used to care for the disease.
Source: Otolaryngologic clinics of North America - February 4, 2013 Category: ENT & OMF Authors: Grant Garbo, Belachew Tessema, Seth M. Brown Source Type: research