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Ask the expert: Is it possible to prevent peanut allergy?
I have seen so many of my friends’ children diagnosed with severe food allergies. Is there anything I can do to stop my baby from having a peanut allergy?   Panicked about peanuts John Lee, MD, clinical director, Boston Children’s Hospital Food Allergy Program Food allergies are on the rise. They are more prevalent than ever before. It is estimated that one in 13 school kids have a life-threatening food allergy. Although some food allergies can be outgrown, peanut allergies tend to be lifelong. In the hope of preventing allergies, doctors used to recommend avoiding foods that are more commonly allergenic—like peanut...
Source: Thrive, Children's Hospital Boston - April 13, 2015 Category: Pediatrics Authors: John Lee Tags: Food allergies Source Type: news

What Proteins Cause Cow ’ s Milk Protein Allergy?
Discussion Cow’s milk protein allergy (CMPA) is one of the most common food allergies. It is estimated to have an incidence of 2-7.5% in infants and a prevalence of 0.5% in breastfeed infants. The prevalence decreases with age at 1% in children > or = 6 years. CMPA does not have a laboratory test and therefore is a clinical diagnosis. It is defined as a “hypersensitivity reaction brought on by specific immunologic mechanisms to cow’s milk.” Generally symptoms present within the first month of life and involve 2 of more systems with 2 or more symptoms. Systems are dermatologic (including atopic de...
Source: PediatricEducation.org - September 11, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

The human milk proteome and allergy of mother and child: Exploring associations with protein abundances and protein network connectivity
ConclusionTogether, these findings give new insights into how the human milk proteome, through differences in the abundance of individual proteins and protein-protein associations, relates to the allergy status of mother and child. In addition, these results inspire new research directions into the complex interplay of the mother-milk-infant triad and allergy.
Source: Frontiers in Immunology - October 13, 2022 Category: Allergy & Immunology Source Type: research

New patient-reported experience measure for children with allergic disease: development, validation and results from integrated care
Conclusions These new PREMs will allow allergy-specific patient experience reporting for children and parents and help identification of priority areas for improvement and commissioning of care. Efforts towards better allergy care provision must be targeted at primary and emergency care settings and underpinned by improving communication between healthcare providers and the community.
Source: Archives of Disease in Childhood - September 18, 2016 Category: Pediatrics Authors: Gore, C., Griffin, R., Rothenberg, T., Tallett, A., Hopwood, B., Sizmur, S., O'Keeffe, C., Warner, J. O. Tags: Immunology (including allergy), Child health Original article Source Type: research

P30 Pharmacist led allergy clinic: Improving paediatric patient care
Conclusions The introduction of a paediatric pharmacist clinic was received positively by the paediatric allergy MDT and the paediatric allergy patients seen (excellent results from patient satisfaction survey). It has contributed to improving patient care, by improving patient safety and reducing waiting times. The outpatient clinic waiting time was reduced by 64% for eczema review after the initiation of topical immunomodulatory therapy for those patients that were referred to the pharmacist clinic and 100% of medication reviews were carried out within 4 weeks of referral. The clinics had significant cost saving implicat...
Source: Archives of Disease in Childhood - April 19, 2023 Category: Pediatrics Authors: Ahmad, S. Tags: Abstract from the Neonatal and Paediatric Pharmacists Conference 2022 Source Type: research

Estimating the prevalence of aero-allergy and/or food allergy in infants, children and young people with moderate-to-severe atopic eczema/dermatitis in primary care: multi-centre, cross-sectional study.
CONCLUSIONS: Although atopic eczema/dermatitis is a very common diagnosis in children in primary care, most appear to be relatively mild and/or transient. Only a small proportion of children had evidence of ongoing underlying IgE-mediated atopic eczema/dermatitis. PMID: 25567768 [PubMed - as supplied by publisher]
Source: J R Soc Med AND (has... - January 7, 2015 Category: Journals (General) Authors: Dhami S, Sheikh A Tags: J R Soc Med Source Type: research

Scientists Find Peanut-Eating Prevents Allergy, Contrary To Prior Health Advice
Mon Feb 23, 2015 4:33pm EST By Kate Kelland LONDON, Feb 23 (Reuters) - In research that contradicts years of health advice, scientists said on Monday that babies at risk of developing a childhood peanut allergy can avoid it if they are given peanuts regularly during their first 11 months. The study, the first to show that eating certain foods is an effective way of preventing allergy, showed an 80 percent reduction in the prevalence of peanut allergies among high-risk children who ate peanuts frequently from infanthood, compared to those who avoided them. "This is an important clinical development and contravenes previo...
Source: Healthy Living - The Huffington Post - February 23, 2015 Category: Consumer Health News Source Type: news

Elevated IL‐5 and IL‐13 responses to egg proteins predate the introduction of egg in solid foods in infants with eczema
Conclusions & Clinical RelevanceElevated egg‐specific Th2 cytokine responses were established prior to egg ingestion at 4 months and were not significantly altered by introduction of egg. Th2 responses at 4 months of age predicted egg allergy at 12 months, suggesting that this could be used as a biomarker to select infants for early prevention and management strategies.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - August 1, 2015 Category: Allergy & Immunology Authors: Jessica R. Metcalfe, Nina D'Vaz, Maria Makrides, Michael S. Gold, Patrick Quinn, Christina E. West, Richard Loh, Susan L. Prescott, Debra J. Palmer Tags: Original Article‐Clinical Mechanisms in Allergic Disease Source Type: research

Probiotics as treatment for food allergies among pediatric patients: a meta-analysis
ConclusionAnalysis of available evidence shows moderate certainty that the use of probiotics can relieve symptoms of children with cow ’s milk allergy. The reduction in certainty is due to imprecise results. Moreover, there is low certainty that probiotics can induce tolerance among children with cow’s milk allergy, due to problems of imprecision and attrition bias. In the subgroup analysis,Lactobacillus rhamnosus GG administration likely results in inducing tolerance among infants with suspected cow ’s milk allergy. Only studies on CMA were analyzed since no studies were found on probiotics as treatment for other ty...
Source: World Allergy Organization Journal - November 6, 2018 Category: Allergy & Immunology Source Type: research

Two‐year follow‐up survey of patients with allergic contact dermatitis from an occupational cohort. Is the prognosis dependent on the omnipresence of the allergen?
ConclusionsOur study confirms the poor prognosis for occupational allergic contact dermatitis. At follow‐up patients with contact urticaria had significantly poorer prognosis than those with contact allergy, and there was a trend towards a poorer prognosis for those with contact allergy to rubber chemicals, representing ubiquitous allergens, than those with allergy to epoxy, representing a non‐ubiquitous allergen. A significant positive association between job change and improvement was found.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - December 20, 2013 Category: Dermatology Authors: K.B.C. Clemmensen, T.K. Carøe, S.F. Thomsen, N.E. Ebbehøj, T. Agner Tags: Cutaneous allergy Source Type: research

Food allergy in children with hypogammaglobulinemia
Conclusions Food allergy is a common health problem coexisting with antibody production defects in infants and young children. Clinical symptoms correlate better with low immunoglobulin levels than with serum IgE, that is not a suitable diagnostic criterion for allergic disease in patients with hypogammaglobulinemia.
Source: Pediatria Polska - November 6, 2014 Category: Pediatrics Source Type: research

Can contact allergy to p‐phenylenediamine explain the high rates of terpene hydroperoxide allergy? – An epidemiological study based on consecutive patch test results
ConclusionsPPD sensitization cannot explain the high rates of sensitization to Lin‐OOHs and/or Lim‐OOHs. Contact allergy to oxidized linalool is more strongly associated with fragrance allergy than with PPD allergy.
Source: Contact Dermatitis - May 31, 2016 Category: Dermatology Authors: Niels Højsager Bennike, Jean‐Pierre Lepoittevin, Jeanne D. Johansen Tags: Original Article Source Type: research

Can contact allergy to p ‐phenylenediamine explain the high rates of terpene hydroperoxide allergy? – An epidemiological study based on consecutive patch test results
ConclusionsPPD sensitization cannot explain the high rates of sensitization to Lin‐OOHs and/or Lim‐OOHs. Contact allergy to oxidized linalool is more strongly associated with fragrance allergy than with PPD allergy.
Source: Contact Dermatitis - May 31, 2016 Category: Dermatology Authors: Niels H øjsager Bennike, Jean‐Pierre Lepoittevin, Jeanne D. Johansen Tags: Original Article Source Type: research

Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial
In this study, we developed a practical approach to overcome the second wave of the allergic epidemic caused by food allergy. Funding Ministry of Health, Labour and Welfare, and National Centre for Child Health and Development, Japan.
Source: The Lancet - December 8, 2016 Category: Journals (General) Source Type: research