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Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia.
DISCUSSION: The use of AChEIs in people with dementia may be associated with reduced risk of ischemic stroke and death. These results call for a closer examination of the cardiovascular effects of AChEIs. PMID: 29706487 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - May 2, 2018 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The association between medical diagnosis and caregiver burden: a cross-sectional study of recipients of informal support and caregivers from the general population study 'Good Aging in Sk åne', Sweden.
CONCLUSION: Informal support constitutes a substantial time for instrumental ADL for the diseased elders. Caregivers to persons with dementia and depression experience high burden. PMID: 29236217 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - December 13, 2017 Category: Geriatrics Authors: Elmståhl S, Dahlrup B, Ekström H, Nordell E Tags: Aging Clin Exp Res Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Thrombolysis in acute ischemic stroke in patients with dementia: A Swedish registry study
Conclusions: Younger patients with dementia and AIS are less likely to receive IVT. Among patients receiving thrombolysis, there are no differences in sICH or death, although patients with dementia have worse accommodation and functional outcomes at 3 months.
Source: Neurology - October 30, 2017 Category: Neurology Authors: Zupanic, E., von Euler, M., Kareholt, I., Contreras Escamez, B., Fastbom, J., Norrving, B., Religa, D., Kramberger, M. G., Winblad, B., Johnell, K., Eriksdotter, M., Garcia-Ptacek, S. Tags: Prognosis, All Cognitive Disorders/Dementia, Cohort studies, Infarction ARTICLE Source Type: research

Blood-thinning drugs may reduce dementia risk in people with irregular heartbeats
Conclusion If you’ve been diagnosed with AF and you have been prescribed anticoagulant treatments such as warfarin or clopidogrel, we already know they protect you against having a stroke. This study suggests they may also help to protect you against dementia. Cutting the risk of dementia for people who have a raised risk because of AF would be an exciting step forward. Unfortunately, we can’t tell from this study whether the protection against dementia was down to the anticoagulants, because of the possible effect of unmeasured confounding factors. Usually, we would want to see a randomised controlled trial (RCT) to f...
Source: NHS News Feed - October 25, 2017 Category: Consumer Health News Tags: Neurology Source Type: news

Prestroke Mobility and Dementia as Predictors of Stroke Outcomes in Patients Over 65  Years of Age: A Cohort Study From The Swedish Dementia and Stroke Registries
To explore the association between prestroke mobility dependency and dementia on functioning and mortality outcomes after stroke in patients>65  years of age.
Source: Journal of the American Medical Directors Association - October 6, 2017 Category: Health Management Authors: Sara Garcia-Ptacek, Beatriz Contreras Escamez, Eva Zupanic, Dorota Religa, Lena von Koch, Kristina Johnell, Mia von Euler, Ingemar K åreholt, Maria Eriksdotter Tags: Original Study Source Type: research

Drug-related problems and medication reviews among old people with dementia.
CONCLUSIONS: Drug-related problems are common among people with dementia and cognitive impairment. Comprehensive medication reviews conducted by clinical pharmacists as part of a health care team might be important to prevent, identify and solve these problems. PMID: 28655357 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - June 30, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

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