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Condition: Mitochondrial Disease
Drug: Melatonin
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Total 88 results found since Jan 2013.
Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress
Biomed Pharmacother. 2023 Sep 16;167:115475. doi: 10.1016/j.biopha.2023.115475. Online ahead of print.ABSTRACTThe vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. These factors cause damage to endothelial cells, leading to the acceleration of CVD progr...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Xiaolu Zhang Yujia Zheng Ziyu Wang Jiali Gan Bin Yu Bin Lu Xijuan Jiang Source Type: research
Melatonin as a potential treatment for septic cardiomyopathy
Biomed Pharmacother. 2023 Aug 22;166:115305. doi: 10.1016/j.biopha.2023.115305. Online ahead of print.ABSTRACTSeptic cardiomyopathy (SCM) is a common complication of sepsis contributing to high mortality rates. Its pathophysiology involves complex factors, including inflammatory cytokines, mitochondrial dysfunction, oxidative stress, and immune dysregulation. Despite extensive research, no effective pharmacological agent has been established for sepsis-induced cardiomyopathy. Melatonin, a hormone with diverse functions in the body, has emerged as a potential agent for SCM through its anti-oxidant, anti-inflammatory, anti-a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 24, 2023 Category: Drugs & Pharmacology Authors: Amira Mohamed Taha Abdelrahman Mohamed Mahmoud Mohamed M Ghonaim Ateeba Kamran Jehad Feras AlSamhori Majd M AlBarakat Abhigan Babu Shrestha Vikash Jaiswal Russel J Reiter Source Type: research
Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling
CONCLUSIONS: We proposed that MT attenuated SONFH by inhibiting ferroptosis through the regulation of GDF15, and supplementation with exogenous MT might be a promising method for the treatment of SONFH.PMID:37400902 | DOI:10.1186/s13287-023-03371-y
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Wenming Li Wenhao Li Wei Zhang Hongzhi Wang Lei Yu Peng Yang Yi Qin Minfeng Gan Xing Yang Lixin Huang Yuefeng Hao Dechun Geng Source Type: research
PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis
In conclusion, targeting USP3-SIRT3-P53 axis may be a novel therapeutic strategy against PM2.5-induced pulmonary inflammation and fibrosis by decreasing pulmonary epithelial senescence and ferroptosis.PMID:37348684 | DOI:10.1016/j.freeradbiomed.2023.06.017
Source: Free Radical Biology and Medicine - June 22, 2023 Category: Biology Authors: Ning Li Rui Xiong Guorui Li Bo Wang Qing Geng Source Type: research
Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway
In conclusion, our studies suggest that the activation of the Sirt1/Nrf2 pathway is the underlying mechanism behind melatonin's ability to curtail oxidative stress, pyroptosis, and apoptosis in Dox-induced cardiomyopathy. These promising results demonstrated the potential application of melatonin as a treatment for doxorubicin-induced cardiac injury.PMID:36965257 | DOI:10.1016/j.biopha.2023.114591
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 25, 2023 Category: Drugs & Pharmacology Authors: Wei Zhang Xi Wang Yanhong Tang Congxin Huang Source Type: research
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why Do Anti-Amyloid Beta Antibodies not work? Time to reconceptualize Dementia Pathophysiology by incorporating astrocyte melatonergic pathway desynchronization from amyloid-beta production
This article highlights the importance of the lost synchronization of Nuclear factor kappa B (NF-κB) and yin yang 1 (YY1) induction of β-site amyloid precursor proteincleaving enzyme (BACE)1 induction and amyloid-β production with the melatonergic pathway. Emphasis is placed on the importance of released glia melatonin and autocrine effects in limiting the duration of amyloid-β production and paracrine melatonin's anti-inflammatory effects in neurons, including the suppression of hyperphosphorylated tau. Many of the broader bodies of data on dementia pathophysiology, including the role of the gut microbiome, gut permea...
Source: Revista Brasileira de Psiquiatria - December 26, 2022 Category: Psychiatry Authors: George Anderson Source Type: research
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases
Biogerontology. 2022 Dec 22. doi: 10.1007/s10522-022-10006-x. Online ahead of print.ABSTRACTAging is associated with increasing impairments in brain homeostasis and represents the main risk factor across most neurodegenerative disorders. Melatonin, a neuroendocrine hormone that regulates mammalian chronobiology and endocrine functions is well known for its antioxidant potential, exhibiting both cytoprotective and chronobiotic abilities. Age-related decline of melatonin disrupting mitochondrial homeostasis and cytosolic DNA-mediated inflammatory reactions in neurons is a major contributory factor in the emergence of neurolo...
Source: Biogerontology - December 22, 2022 Category: Geriatrics Authors: Avnish Kumar Verma Sandeep Singh Syed Ibrahim Rizvi Source Type: research
