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Condition: Mitochondrial Disease
Drug: Metformin
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Total 153 results found since Jan 2013.
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitophagy-promoting agents and their ability to promote healthy-aging
In conclusion, this article provides an up-to-date source of information about natural and synthetic substances that activate mitophagy and, hopefully, stimulates new hypotheses and studies that promote healthy human aging worldwide.PMID:37650304 | DOI:10.1042/BST20221363
Source: Biochemical Society Transactions - August 31, 2023 Category: Biochemistry Authors: Vijigisha Srivastava Einav Gross Source Type: research
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metformin role in Parkinson's disease: a double-sword effect
Mol Cell Biochem. 2023 Jun 2. doi: 10.1007/s11010-023-04771-7. Online ahead of print.ABSTRACTParkinson's disease (PD) is a common neurodegenerative disease developed due to the degeneration of dopaminergic neurons in the substantia nigra. There is no single effective treatment in the management of PD. Therefore, repurposing effective and approved drugs like metformin could be an effective strategy for managing PD. However, the mechanistic role of metformin in PD neuropathology was not fully elucidated. Metformin is an insulin-sensitizing agent used as a first-line therapy in the management of type 2 diabetes mellitus (T2DM...
Source: Molecular and Cellular Biochemistry - June 2, 2023 Category: Biochemistry Authors: Mohamed Alrouji Hayder M Al-Kuraishy Ali I Al-Gareeb Nada A Ashour Majid S Jabir Walaa A Negm Gaber El-Saber Batiha Source Type: research
Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion
This study aims to evaluate the protective effect of metformin against retinal I/R injury and its underlying mechanism. I/R induced reduction in retina thickness and cell number in ganglion cell layer, and metformin alleviated I/R-induced retinal injury. Both retinal I/R and simulated ischemia/reperfusion (SIR) in R28 cells down-regulated expression of mitochondrial fusion protein Mfn2 and OPA1, which led to mitochondrial fission. Metformin also alleviated damage in R28 cells, and reversed the alteration in Mfn2 and OPA1, mitochondrial fission and mitochondrial membrane potential (MMP) disruption-induced by I/R or SIR as w...
Source: Free Radical Biology and Medicine - May 30, 2023 Category: Biology Authors: Kun Zhang Tao Wang Gui-Feng Sun Jin-Xing Xiao Li-Ping Jiang Fang-Fang Tou Xin-Hui Qu Xiao-Jian Han Source Type: research
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Glucose metabolism impairment in Parkinson's disease
Brain Res Bull. 2023 May 18;199:110672. doi: 10.1016/j.brainresbull.2023.110672. Online ahead of print.ABSTRACTImpairments in systematic and regional glucose metabolism exist in patients with Parkinson's disease (PD) at every stage of the disease course, and such impairments are associated with the incidence, progression, and special phenotypes of PD, which affect each physiological process of glucose metabolism including glucose uptake, glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and pentose phosphate shunt pathway. These impairments may be attributed to various mechanisms, such as insulin resistance,...
Source: Brain Research Bulletin - May 20, 2023 Category: Neurology Authors: Chengcheng Dai Changhong Tan Lili Zhao Yi Liang Guohui Liu Hang Liu Yuke Zhong Zhihui Liu Lijuan Mo Xi Liu Lifen Chen Source Type: research
Metabolic Complications of Glucocorticoids - Prevention by Metformin
Ann Endocrinol (Paris). 2023 May 18:S0003-4266(23)00105-1. doi: 10.1016/j.ando.2023.05.002. Online ahead of print.ABSTRACTGlucocorticoid treatment is prescribed in 2-3% of the population for various diseases. Chronic exposure to excess glucocorticoid can lead to iatrogenic Cushing's syndrome, which is associated with increased morbidity, especially from cardiovascular diseases and infections. While several 'steroid-sparing' drugs have been introduced, glucocorticoid treatment is still applied in a large number of patients. We have previously showed that the enzyme AMPK plays a key role in mediating the metabolic effects of...
Source: Annales d'Endocrinologie - May 20, 2023 Category: Endocrinology Authors: Kanokporn Sanpawithayakul M árta Korbonits Source Type: research
Glucose metabolism impairment in Parkinson's disease
Brain Res Bull. 2023 May 18;199:110672. doi: 10.1016/j.brainresbull.2023.110672. Online ahead of print.ABSTRACTImpairments in systematic and regional glucose metabolism exist in patients with Parkinson's disease (PD) at every stage of the disease course, and such impairments are associated with the incidence, progression, and special phenotypes of PD, which affect each physiological process of glucose metabolism including glucose uptake, glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and pentose phosphate shunt pathway. These impairments may be attributed to various mechanisms, such as insulin resistance,...
Source: Brain Research Bulletin - May 20, 2023 Category: Neurology Authors: Chengcheng Dai Changhong Tan Lili Zhao Yi Liang Guohui Liu Hang Liu Yuke Zhong Zhihui Liu Lijuan Mo Xi Liu Lifen Chen Source Type: research
Metabolic Complications of Glucocorticoids - Prevention by Metformin
Ann Endocrinol (Paris). 2023 May 18:S0003-4266(23)00105-1. doi: 10.1016/j.ando.2023.05.002. Online ahead of print.ABSTRACTGlucocorticoid treatment is prescribed in 2-3% of the population for various diseases. Chronic exposure to excess glucocorticoid can lead to iatrogenic Cushing's syndrome, which is associated with increased morbidity, especially from cardiovascular diseases and infections. While several 'steroid-sparing' drugs have been introduced, glucocorticoid treatment is still applied in a large number of patients. We have previously showed that the enzyme AMPK plays a key role in mediating the metabolic effects of...
Source: Annales d'Endocrinologie - May 20, 2023 Category: Endocrinology Authors: Kanokporn Sanpawithayakul M árta Korbonits Source Type: research
Glucose metabolism impairment in Parkinson's disease
Brain Res Bull. 2023 May 18;199:110672. doi: 10.1016/j.brainresbull.2023.110672. Online ahead of print.ABSTRACTImpairments in systematic and regional glucose metabolism exist in patients with Parkinson's disease (PD) at every stage of the disease course, and such impairments are associated with the incidence, progression, and special phenotypes of PD, which affect each physiological process of glucose metabolism including glucose uptake, glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and pentose phosphate shunt pathway. These impairments may be attributed to various mechanisms, such as insulin resistance,...
Source: Brain Research - May 20, 2023 Category: Neurology Authors: Chengcheng Dai Changhong Tan Lili Zhao Yi Liang Guohui Liu Hang Liu Yuke Zhong Zhihui Liu Lijuan Mo Xi Liu Lifen Chen Source Type: research
