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Specialty: Cancer & Oncology
Condition: Mitochondrial Disease

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Total 22 results found since Jan 2013.

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Abstract 3047: Mitochondrial DNA copy variation and TFAM expression in astrocytoma
Mitochondrial dysfunction plays a role in determining the phenotype through bioenergetic depletion and increased production of ROS in several diseases, including cancer. We have previously demonstrated a relevant reduction of mitochondrial DNA (mtDNA) copy number in astrocytoma of different grades of malignancy, predominantly in grade IV-glioblastoma (GBM). We observed a stepwise increase of TFAM in parallel to the increase of malignancy, and TFAM expression was higher in GBM patients with overall survival longer than 24 months than less than 12 months. TFAM is codified in the nucleus and transported into mitochondria, whe...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Marie, S. K., Silva, R., Lerario, A., Uno, M., Oba-Shinjo, S. M. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3045: Novel altered mitochondrial genes in prostate cancer progression
Conclusions: We have identified mitochondria genes that are differentially expressed in PCa cells lines and prostatectomy tissues with different malignancy phenotypes. These findings are currently being validated using disease stratified TMAs. Further studies are focusing on uncovering the mechanisms responsible for progression and metastasis of PCa that are modulated by mitochondria associated genes. These could assist in the development of novel diagnostic and therapeutic strategies for the disease.Citation Format: Tanya C. Burch, J S. Rhim, Julius O. Nyalwidhe. Novel altered mitochondrial genes in prostate cancer progre...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Burch, T. C., Rhim, J. S., Nyalwidhe, J. O. Tags: Molecular and Cellular Biology Source Type: research

Abstract C1: Harnessing the pro-inflammatory tumor microenvironment of castrate-resistant prostate cancer to promote apoptosis
ConclusionProstate cancer cell lines are inherently resistant to SMAC mimetic therapy even in the presence of TNFα or TRAIL. However, dual targeting of FLIP and IAPs sensitises CRPC cell lines to microenvironment-derived TNFα. Combined targeting of IAPs and FLIP, or single targeting of FLIP, may be an effective means of treating pro-inflammatory prostate cancer.Citation Format: Christopher McCann, Nyree Crawford, David Waugh, Daniel Longley. Harnessing the pro-inflammatory tumor microenvironment of castrate-resistant prostate cancer to promote apoptosis. [abstract]. In: Proceedings of the AACR-NCI-EORTC Interna...
Source: Molecular Cancer Therapeutics - January 7, 2016 Category: Cancer & Oncology Authors: McCann, C., Crawford, N., Waugh, D., Longley, D. Tags: Apoptosis, Necrosis, and Autophagy: Poster Presentations - Proffered Abstracts Source Type: research

TNF α affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics.
TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics. Oncotarget. 2017 Jul 21;: Authors: Jensen P, Myhre CL, Lassen PS, Metaxas A, Khan AM, Lambertsen KL, Babcock AA, Finsen B, Larsen MR, Kempf SJ Abstract Neuroinflammation is a hallmark of Alzheimer's disease and TNFα as the main inducer of neuroinflammation has neurodegenerative but also pro-regenerative properties, however, the dose-dependent molecular changes on signaling pathway level are not fully understood. We performed quantitative proteomics and phos...
Source: Oncotarget - July 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Involvement of < em > NEAT1 < /em > /PINK1-mediated mitophagy in chronic obstructive pulmonary disease induced by cigarette smoke or PM < sub > 2.5 < /sub >
CONCLUSIONS: Our results suggest that CS and PM2.5 exposure induce mitochondrial dysfunction, and the NEAT1/PINK1 pathway plays a critical role in the occurrence and development of COPD by regulating mitophagy.PMID:35433942 | PMC:PMC9011272 | DOI:10.21037/atm-22-542
Source: Cancer Control - April 18, 2022 Category: Cancer & Oncology Authors: Qi Lin Chao-Feng Zhang Jin-Ling Guo Jian-Lin Su Zhen-Kun Guo Huang-Yuan Li Source Type: research

Cancers, Vol. 15, Pages 1397: PCSK9 Inhibitors in Cancer Patients Treated with Immune-Checkpoint Inhibitors to Reduce Cardiovascular Events: New Frontiers in Cardioncology
nno Nicola Maurea Cancer patients treated with immune checkpoint inhibitors (ICIs) are exposed to a high risk of atherosclerosis and cardiometabolic diseases due to systemic inflammatory conditions and immune-related atheroma destabilization. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key protein involved in metabolism of low-density lipoprotein (LDL) cholesterol. PCSK9 blocking agents are clinically available and involve monoclonal antibodies, and SiRNA reduces LDL levels in high-risk patients and atherosclerotic cardiovascular disease events in multiple patient cohorts. Moreover, PCSK9 induces perip...
Source: Cancers - February 22, 2023 Category: Cancer & Oncology Authors: Vincenzo Quagliariello Irma Bisceglia Massimiliano Berretta Martina Iovine Maria Laura Canale Carlo Maurea Vienna Giordano Andrea Paccone Alessandro Inno Nicola Maurea Tags: Review Source Type: research

TR3 Dysfunction in Ovarian Cancer
In metastatic ovarian cancer, resistance to platinum chemotherapy is common. Although the orphan nuclear receptor TR3 (nur77/NR4A1) is implicated in mediating chemotherapy-induced apoptosis in cancer cells, its role in ovarian cancer has not been determined. In an ovarian cancer tissue microarray, TR3 protein expression was elevated in stage I tumors, but downregulated in a significant subset of metastatic tumors. Moreover, TR3 expression was significantly lower in platinum-resistant tumors in patients with metastatic disease, and low TR3 staining was associated with poorer overall and progression-free survival. We have id...
Source: Cancer Research - July 31, 2013 Category: Cancer & Oncology Authors: Wilson, A. J., Liu, A. Y., Roland, J., Adebayo, O. B., Fletcher, S. A., Slaughter, J. C., Saskowski, J., Crispens, M. A., Jones, H. W., James, S., Fadare, O., Khabele, D. Tags: Molecular and Cellular Pathobiology Source Type: research

Nucleic acid-based tissue biomarkers of urologic malignancies.
This article provides an overview of nucleic acid-based biomarkers in tissues for the management of urologic malignancies, i.e. tumors of the prostate, testis, kidney, penis, urinary bladder, renal pelvis, ureter and other urinary organs. Special emphasis is put on genomic, transcriptomic and epigenomic biomarkers (SNPs, mutations [genomic and mitochondrial], microsatellite instabilities, viral and bacterial DNA, DNA methylation and hydroxymethylation, mRNA expression, and non-coding RNAs [lncRNA, miRNA, siRNA, piRNA, snRNA, snoRNA]). Due to the multitude of published biomarker candidates, special focus is given to the gen...
Source: Clinical Prostate Cancer - May 30, 2014 Category: Cancer & Oncology Authors: Dietrich D, Meller S, Uhl B, Ralla B, Stephan C, Jung K, Ellinger J, Kristiansen G Tags: Crit Rev Clin Lab Sci Source Type: research

Abstract 3956: Combination of SPARC and radiation suppresses HSP27 and induces p21(CIP1/WAF1) in neuroblastoma tumor cells
Neuroblastoma (NBL) is the third most common malignancy in children and accounts for more than 15% of cancer-related deaths in children in the US. Approximately 50% of patients present with advanced-stage and/or high risk disease. Despite significant intensification of conventional chemotherapy regimens, the long-term survival rates for these children remain less than 40%. A somewhat improved outcome has been obtained with multimodality therapeutic approaches including chemotherapy, surgery, autologous bone marrow transplantation, radiation therapy and use of biological agents. However, long-term survival rates for childre...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gondi, C. S., Tanpure, S., Antony, R., Fernandez, K. S., Guȷrati, M., Lin, J. Tags: Tumor Biology Source Type: research

Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced cell death of stomach adenocarcinoma cells in vitro.
Abstract Oncolytic viruses can kill malignant cells while sparing normal cells. Multiple pathways are involved in this action. The antitumor effects of viral infection on SGC-7901 and AGS cells were investigated. We measured endoplasmic reticulum stress and autophagy caused by the recombinant avirulent Newcastle disease virus (NDV) LaSota strain expressing the rabies virus glycoprotein (rL-RVG) and the NDV wild-type strain. The dose-response curves were analyzed using the MTT assay. The expression of RVG was detected by western blotting, RT-PCR and immunofluorescence analyses. Cell death and autophagy were observe...
Source: International Journal of Oncology - June 9, 2015 Category: Cancer & Oncology Authors: Bu XF, Wang MB, Zhang ZJ, Zhao YH, Li M, Yan YL Tags: Int J Oncol Source Type: research

C-Raf Colocalizes with DAPK in the Mitochondria
This study identified the interaction of C-Raf with S308 phosphorylated DAPK (pDAPKS308), which together became colocalized in the mitochondria to facilitate mitochondrial remodeling. Combined use of the Raf inhibitors sorafenib and GW5074 had synergistic anticancer effects in vitro and in vivo, but targeted mitochondrial function, rather than the canonical Raf signaling pathway. C-Raf depletion in knockout MEFC-Raf−/− or siRNA knockdown ACHN renal cancer cells abrogated the cytotoxicity of combination therapy. Crystal structure simulation showed that GW5074 bound to C-Raf and induced a C-Raf conformational change that...
Source: Cancer Research - August 31, 2015 Category: Cancer & Oncology Authors: Tsai, Y.-T., Chuang, M.-J., Tang, S.-H., Wu, S.-T., Chen, Y.-C., Sun, G.-H., Hsiao, P.-W., Huang, S.-M., Lee, H.-J., Yu, C.-P., Ho, J.-Y., Lin, H.-K., Chen, M.-R., Lin, C.-C., Chang, S.-Y., Lin, V. C., Yu, D.-S., Cha, T.-L. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

Abstract B19: MYC induces PLD6 to suppress YAP/TAZ-dependent self-renewal of mammary stem cells
For the maintenance of a given tissue it is absolutely critical to balance proliferation and differentiation of stem cells, progenitor cells and terminally differentiated cells. Perturbations of these finely tuned processes can lead to various diseases such as cancer.One factor that has been implicated in the transition from a stem cell to a progenitor/ transit-amplifying cell is the oncogenic transcription factor MYC. Paradoxically, despite its strong pro-tumorigenic capabilities it has been shown to promote differentiation in several tissues such as the skin or the hematopoietic system.To identify critical pathways that ...
Source: Molecular Cancer Research - October 18, 2015 Category: Cancer & Oncology Authors: Eyss, B. v., Jaenicke, L. A., Wiese, K., Rosenwald, A., Eilers, M. Tags: Myc Beyond Cancer: Poster Presentations - Proffered Abstracts Source Type: research

Abstract A12: Establishment of myeloid lineage cell line that resembles myeloid-derived suppressive cells
Myeloid-derived suppressive cells (MDSCs) are inflammatory cells that play critical roles in promoting cancer growth and metastasis. In order to facilitate characterization of biochemical and cellular mechanisms of MDSCs, it is urgent to establish an "MDSC-like" cell line for pharmacological and immunotherapeutic applications. Lysosomal acid lipase (LAL) is a critical lipid enzyme in the metabolic signaling pathway that hydrolyzes cholesteryl esters (CE) and triglycerides (TG) in lysosomes. In mice, lack of LAL in genetically ablated knockout mice (lal-/-) shows systemic expansion of MDSCs, which directly stimulate cancer ...
Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Yan, C., Ding, X., Wu, L., Du, H. Tags: Cancer Metabolic Pathways: Poster Presentations - Proffered Abstracts Source Type: research