Abstract 3045: Novel altered mitochondrial genes in prostate cancer progression

Conclusions: We have identified mitochondria genes that are differentially expressed in PCa cells lines and prostatectomy tissues with different malignancy phenotypes. These findings are currently being validated using disease stratified TMAs. Further studies are focusing on uncovering the mechanisms responsible for progression and metastasis of PCa that are modulated by mitochondria associated genes. These could assist in the development of novel diagnostic and therapeutic strategies for the disease.Citation Format: Tanya C. Burch, J S. Rhim, Julius O. Nyalwidhe. Novel altered mitochondrial genes in prostate cancer progression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3045. doi:10.1158/1538-7445.AM2015-3045

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Burch, T. C., Rhim, J. S., Nyalwidhe, J. O. Tags: Molecular and Cellular Biology Source Type: research