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Condition: Autoimmune Disease
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Total 293 results found since Jan 2013.

Antiphospholipid syndrome-mediated acute cerebrovascular diseases and long-term outcomes
CONCLUSION: We found no differences between stroke subtypes and APS types. aPL profiles were not associated with any of the acute cerebrovascular diseases described in this cohort. CVT may be an initial thrombotic manifestation of APS with low mortality and good long-term functional outcome.PMID:35042376 | DOI:10.1177/09612033221074178
Source: Lupus - January 19, 2022 Category: Rheumatology Authors: Miguel Garc ía-Grimshaw Diego Rub én Posadas-Pinto Amado Jim énez-Ruiz Sergio Iv án Valdés-Ferrer Arturo Cadena-Fern ández Jos é Jiram Torres-Ruiz Jos é Domingo Barrientos-Guerra Margarita Amancha-Gabela Erwin Chiquete Fernando Daniel Flores-Silva Source Type: research

O-015 What can systemic and intracranial proteomic profiles tell us about why some TICI 3 patients do better than others?
In conclusion, intracranial and systemic proteomic differences in TICI 3 subjects may inform why some outcomes are superior to others. Preliminary data presented here provide a springboard for further investigation into how proteins may serve as prognostic biomarkers or therapeutic targets in a subset of MT subjects.Disclosures B. Maglinger: None. J. Frank: None. L. Sheikhi: None. S. Pahwa: None. D. Dornbos: None. C. Rupareliya: None. C. McLouth: None. A. Trout: None. J. Turchan-Cholewo: None. A. Stowe: 4; C; Cerelux, LLC. J. Fraser: 1; C; AHA. 2; C; Penumbra, Medtronic, Stream Biomedical. 4; C; Fawkes Biotechnology; Cerel...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Maglinger, B., Frank, J., Sheikhi, L., Pahwa, S., Dornbos, D., Rupareliya, C., McLouth, C., Trout, A., Turchan-Cholewo, J., Stowe, A., Fraser, J., Pennypacker, K. Tags: SNIS 19th annual meeting oral abstracts Source Type: research

Distinct lesion features and underlying mechanisms in patients with acute multiple infarcts in multiple cerebral territories
ConclusionThe etiologies and mechanisms of patients with AMIMCT were more complex than those without AMIMCT. The distribution characteristics of infarct lesions might have important implications for the identification of etiology and mechanism in the future, which could further guide and optimize clinical diagnostic strategies.
Source: Frontiers in Neurology - January 16, 2023 Category: Neurology Source Type: research

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study.
CONCLUSIONS: These findings suggest that DMS is associated with an increased risk of cardiovascular and cerebrovascular events. PMID: 23330740 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 21, 2013 Category: Dermatology Authors: Lai YT, Dai YS, Yen MF, Chen LS, Chen HH, Cooper RG, Pan SL Tags: Br J Dermatol Source Type: research

Lasting Relief from Chronic Pain after Cerebral Infarction (P02.005)
CONCLUSIONS: This patient's stroke appeared to produce the beneficial and persistent effect of dramatic pain relief, enabling him to discontinue all analgesic medications, including methadone. The alleviation of pain after ischemic infarction is highly unusual, and possible explanations include 1) damage to both anterior cingulate gyri producing apathy of such severity that the experience of pain was markedly blunted, and 2) bilateral injury to the nucleus accumbens abolishing a cerebral region critical for the appreciation of pain and opiate-related reward.Disclosure: Dr. Burke has nothing to disclose. Dr. Anderson's spou...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Burke, H., Anderson, C., Filley, C. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Use of E-Selectin Tolerization as Treatment for Immunological and Vascular-Related Disorders
This technology relates to the mucosal delivery (e.g. intranasal) of an E-selectin fragment as a tolerization agent for the prevention and treatment of immunological and vascular-related disorders, including stroke and multiple sclerosis (MS) as well as rare or orphan diseases involving vascular modulated disorders. E-selectin is an adhesion molecule that is expressed on endothelial cells lining blood vessels in response to certain localized cytokines, making the endothelial surface pro-coagulant, pro-inflammatory and/or immunoreactive. Such changes on the endothelial surface have been linked to the development of vascula...
Source: NIH OTT Licensing Opportunities - April 1, 2001 Category: Research Authors: admin Source Type: research

Lupus patients 'at higher risk of developing other health conditions'
People with lupus are at a greater risk of developing other health conditions than members of the general population.This is according to a new study conducted by the University of Nottingham and the Arthritis Research UK Primary Care Centre at Keele University, which examined the frequency of comorbidities associated with systemic lupus erythematosus in the UK between 1999 and 2012.A broad UK study Published in the medical journal Arthritis Care & Research, the study drew upon data from the UK Clinical Practice Research Datalink, identifying cases of lupus and matching each one by age, gender and practice to four heal...
Source: Arthritis Research UK - May 26, 2016 Category: Rheumatology Source Type: news

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population‐based longitudinal follow‐up study
ConclusionsThese findings suggest that DMS is associated with an increased risk of cardiovascular and cerebrovascular events.
Source: British Journal of Dermatology - January 1, 2013 Category: Dermatology Authors: Y.‐T. Lai, Y.‐S. Dai, M.‐F. Yen, L.‐S. Chen, H.‐H. Chen, R.G. Cooper, S.‐L. Pan Tags: Original Article Source Type: research

Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection
Conclusions Antiviral treatment for HCV is associated with improved renal and circulatory outcomes, but unrelated to catastrophic autoimmune diseases.
Source: Gut - February 3, 2015 Category: Gastroenterology Authors: Hsu, Y.-C., Ho, H. J., Huang, Y.-T., Wang, H.-H., Wu, M.-S., Lin, J.-T., Wu, C.-Y. Tags: Hepatology Source Type: research

The role of IL-17 in CNS diseases
Abstract Cytokines of the IL-17 family are uniquely placed on the border between immune cells and tissue. Although IL-17 was originally found to induce the activation and mobilization of neutrophils to sites of inflammation, its tissue-specific function is not yet fully understood. The best-studied IL-17 family members, IL-17A and IL-17F, are both typically produced by immune cells such as Th17, γδ T cells and innate lymphoid cells group 3. However, the cells that respond to these cytokines are mostly found in inflamed tissue. As seen in psoriatic skin lesions or in joints of rheumatoid arthritis patients, high ...
Source: Acta Neuropathologica - February 26, 2015 Category: Neurology Source Type: research