Filtered By:
Condition: Pulmonary Hypertension

This page shows you your search results in order of relevance. This is page number 10.

Order by Relevance | Date

Total 621 results found since Jan 2013.

Distinct loading conditions reveal various patterns of right ventricular adaptation
Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct types of RV loading have been associated with different outcomes. To determine whether the adaptive RV response depends on loading type, we compared hemodynamics, exercise, and hypertrophy in models of pressure overload due to pulmonary artery banding (PAB), pressure overload due to PH, combined pressure and volume overload, and isolated volume load. Ninety-four rats were subjected to either PAB, monocrotaline-induced PH (PH), aortocaval shunt (sh...
Source: AJP: Heart and Circulatory Physiology - August 1, 2013 Category: Cardiology Authors: Borgdorff, M. A. J., Bartelds, B., Dickinson, M. G., Steendijk, P., de Vroomen, M., Berger, R. M. F. Tags: MUSCLE MECHANICS AND VENTRICULAR FUNCTION Source Type: research

Systemic Hypertension in Low Gradient Severe Aortic Stenosis with Preserved Ejection Fraction.
CONCLUSIONS: Systemic hypertension in LG severe AS with preserved EF is associated with elevated LV filling pressures and pulmonary hypertension. Treatment of hypertension with vasodilator therapy results in a lowering of the total LV afterload, with a decrease in LV filling pressures and pulmonary artery pressures. These findings have important implications for the management of patients with LG severe AS with preserved EF and hypertension. PMID: 23956211 [PubMed - as supplied by publisher]
Source: Circulation - August 16, 2013 Category: Cardiology Authors: Eleid MF, Nishimura RA, Sorajja P, Borlaug BA Tags: Circulation Source Type: research

Bosentan Treatment Is Associated With Improvement of Right Ventricular Function and Remodeling in Chronic Thromboembolic Pulmonary Hypertension
ConclusionsIn CTEPH, compared with control, treatment with bosentan for 16 weeks was associated with a significant improvement in cMRI parameters of RV function and remodelling.
Source: Clinical Cardiology - August 27, 2013 Category: Cardiology Authors: Sulaiman Surie, Herre J. Reesink, J. Tim Marcus, Mart N. van der Plas, Jaap J. Kloek, Anton Vonk‐Noordegraaf, Paul Bresser Tags: Clinical Investigation Source Type: research

Strong linear relationship between heart rate and mean pulmonary artery pressure in exercising patients with severe precapillary pulmonary hypertension
The contribution of heart rate (HR) to pulmonary artery hemodynamics has been suggested in pulmonary hypertension (PH). Our high-fidelity pressure, retrospective study tested the hypothesis that HR explained the majority of mean pulmonary artery pressure (mPAP) and pulse pressure (PApp) variation in 12 severe precapillary PH patients who performed incremental-load cycling while in the supine position. Seven idiopathic pulmonary arterial hypertension patients and five chronic thromboembolic PH patients were studied. Four to five PAP-thermodilution cardiac output (CO) points (mean: 4.4) were obtained. At rest, mPAP was 57 &p...
Source: AJP: Heart and Circulatory Physiology - September 1, 2013 Category: Cardiology Authors: Chemla, D., Castelain, V., Hoette, S., Creuze, N., Provencher, S., Zhu, K., Humbert, M., Herve, P. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research

Value of Impedance Cardiography during 6‐Minute Walk Test in Pulmonary Hypertension
ConclusionsEstimation of hemodynamic parameters such as cardiac index during 6‐minute walk test is feasible and may provide useful information in patients with PH. Clin Trans Sci 2013; Volume #: 1–7
Source: Clinical and Translational Science - August 1, 2013 Category: Biomedical Science Authors: Adriano R. Tonelli, Laith Alkukhun, Vineesha Arelli, José Ramos, Jennie Newman, Kevin McCarthy, Bohdan Pichurko, Omar A. Minai, Raed A. Dweik Tags: Article Source Type: research

Right Ventricular Dysfunction in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension Original Articles
Conclusions— RV dysfunction is worse in SScPAH compared with IPAH at similar afterload, and may be because of intrinsic systolic function rather than enhanced pulmonary vascular resistive and pulsatile loading.
Source: Circulation: Heart Failure - September 17, 2013 Category: Cardiology Authors: Tedford, R. J., Mudd, J. O., Girgis, R. E., Mathai, S. C., Zaiman, A. L., Housten-Harris, T., Boyce, D., Kelemen, B. W., Bacher, A. C., Shah, A. A., Hummers, L. K., Wigley, F. M., Russell, S. D., Saggar, R., Saggar, R., Maughan, W. L., Hassoun, P. M., Kas Tags: Other heart failure, Pulmonary circulation and disease Original Articles Source Type: research

138 * transapical aortic valve implantation in patients with and without severe calcification of the ascending aorta: different preoperative characteristics but no difference in outcome
Conclusions: In contrast to conventional aortic valve replacement, severe calcification of the ascending aorta has no negative influence on perioperative outcome and long-term survival after transapical TAVI.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Buz, S., Pasic, M., Drews, T., Dreysse, S., Kukucka, M., Mladenow, A., Hetzer, R., Unbehaun, A. Tags: Transcatheter aortic valve implantation: Expanding indications and techniques Source Type: research

Continuous Flow Left Ventricular Assist Device Implant Significantly Improves Pulmonary Hypertension, Right Ventricular Contractility, and Tricuspid Valve Competence
ConclusionContinuous flow LVAD implant improves pulmonary hypertension, RV function, and tricuspid regurgitation. TR may be managed nonoperatively during CF LVAD implant.
Source: Journal of Cardiac Surgery - September 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Pavan Atluri, Alexander S. Fairman, John W. MacArthur, Andrew B. Goldstone, Jeffrey E. Cohen, Jessica L. Howard, Christyna M. Zalewski, Yasuhiro Shudo, Y. Joseph Woo Tags: Original Article Source Type: research

Pulsatile haemodynamic parameters are predictors of survival in paediatric pulmonary arterial hypertension
Conclusions: The parameters of both the pulsatile and static pulmonary circulations are strong independent predictors for transplant-free survival, and therefore can be of complementary value in assessing disease severity, predicting survival and guiding treatment in paediatric PAH.
Source: International Journal of Cardiology - January 21, 2013 Category: Cardiology Authors: Johannes M. Douwes, Marcus T.R. Roofthooft, Beatrijs Bartelds, Melle D. Talsma, Hans L. Hillege, Rolf M.F. Berger Tags: Original Articles Source Type: research

Rho Kinases in Cardiovascular Physiology and Pathophysiology: The Effect of Fasudil
Abstract:Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin cytoskeleton and is involved in a wide range of fundamental cellular functions, such as contraction, adhesion, migration, proliferation, and apoptosis. Due to the discovery of effective inhibitors, such as fasudil and Y27632, the biological roles of ROCK have been extensively explored with particular attention on the cardiovascular system. In many preclinical models of cardiovascular diseases, including vasospasm, arteriosclerosis, hypertension, pul...
Source: Journal of Cardiovascular Pharmacology - October 1, 2013 Category: Cardiology Tags: Invited Review Article Source Type: research

Clinical Inquiry: Elevated troponin but no CVD: What's the prognosis?
Abstract Patients with elevated troponin levels and chronic renal disease, pulmonary hypertension, pulmonary embolism, chronic obstructive pulmonary disease, sepsis, or acute ischemic stroke have a 2- to 5-fold increased risk of death, even in the absence of known cardiovascular disease. PMID: 24143353 [PubMed - in process]
Source: The Journal of Family Practice - October 1, 2013 Category: Practice Management Authors: Mantzouris T, Gauer R, Mackler L Tags: J Fam Pract Source Type: research

"Cardiovascular diseases should be higher on the political agenda" said Tonio Borg, the EU commissioner for health.
Cardiovascular disease is the number one killer in the EU, but it is not yet given enough importance on the political agenda, according to Tonio Borg, who has scheduled an EU summit on chronic diseases at the beginning of next year.He spoke at the launch of the Cardiovascular Health Week, an initiative by the MEP Heart Group. Read the article. Topics: Acute Coronary Syndromes (ACS), Arrhythmias, Atherosclerosis, Atrial Fibrillation, Basic Science, Cardiac Tumours, Cardiovascular Disease Prevention - Risk Assessment and Management, Cardiovascular Nursing, Cardiovascular Surgery, Chron...
Source: ESC News and Press - November 12, 2013 Category: Cardiology Source Type: news

Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease
Abstract: In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfunction subphenotype (HED) suffer from stroke and pulmonary hypertension and have an elevated concentration of lactate dehydrogenase. However, this classification is not possible in children due to low rates of complications. We used laboratory markers to classify children into the two subphenotypes, and ...
Source: Thrombosis Research - October 31, 2013 Category: Hematology Authors: Veronica van der Land, Marjolein Peters, Bart J. Biemond, Harriët Heijboer, Cornelis L. Harteveld, Karin Fijnvandraat Tags: Platelets and Cell Biology Source Type: research

Survival after lung transplantation in systemic sclerosis. A systematic review
Conclusion: The short-term and intermediate-term survival post-lung transplantation are similar to IPAH and ILD patients requiring lung transplantation.
Source: Respiratory Medicine CME - October 9, 2013 Category: Respiratory Medicine Authors: Irfan Y. Khan, Lianne G. Singer, Marc de Perrot, John T. Granton, Shaf Keshavjee, Cathy Chau, Amie Kron, Sindhu R. Johnson Tags: Transplantation Source Type: research

Echocardiography of the pulmonary circulation and right ventricular function: exploring the physiologic spectrum in 1480 normal subjects.
CONCLUSIONS. This study delineates an estimate of pulmonary hemodynamics in a wide age range cohort of healthy subjects. Pulmonary pressures increased with age and BMI as expected. PMID: 24306729 [PubMed - as supplied by publisher]
Source: Chest - December 5, 2013 Category: Respiratory Medicine Authors: D'Andrea A, Naeije R, Grünig E, Caso P, D'Alto M, Palma ED, Nunziata L, Riegler L, Scarafile R, Cocchia R, Vriz O, Citro R, Calabrò R, Russo MG, Bossone E Tags: Chest Source Type: research