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Post ‐operative serious adverse events in a mixed surgical population – a retrospective register study
ConclusionWe found a risk of one or more events in the composite outcome within 342 days after inclusion of the last patients of 8.3% (7.8–9.0). The results are applicable in estimations of adequate sample sizes in future clinical trials investigating effects of interventions on SAEs.
Source: Acta Anaesthesiologica Scandinavica - July 13, 2016 Category: Anesthesiology Authors: M. S. Hansen, E. E. Petersen, J. B. Dahl, J. Wetterslev Tags: Original Article Source Type: research

New imaging method may predict risk of post-treatment brain bleeding after stroke
In a study of stroke patients, investigators confirmed through MRI brain scans that there was an association between the extent of disruption to the brain's protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology.
Source: ScienceDaily Headlines - June 18, 2016 Category: Science Source Type: news

Cardiovascular highlights from non-cardiology journals
Pre-operative aspirin does not influence CABG outcomes Aspirin is a common therapy for risk reduction among patients with coronary artery disease. However, among patients undergoing coronary artery bypass surgery, the benefits of aspirin on the risk of myocardial infarction and stroke may be outweighed by perioperative bleeding risk. To address this question, the ATACAS trial randomized 2100 patients to either receive 100 mg aspirin daily or matching placebo for 4 days immediately prior to the operation with all patients resuming aspirin within 24 hours of their bypass surgery. The primary outcome was a composite of d...
Source: Heart - June 5, 2016 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Study: 'mini strokes should be treated immediately with aspirin'
Conclusion The study supports current recommended practice that people with a TIA or ischaemic stroke caused by a blood clot are treated with aspirin as soon as possible. NHS experts are considering whether to recommend that you take aspirin yourself while waiting for medical help. The reason this isn't recommended at present is that some people will have had a haemorrhagic (bleeding) stroke, and aspirin can make the bleeding worse. For people who've had a full stroke, an urgent brain scan is usually performed to exclude bleeding as a cause and check it's safe to proceed with anti-clotting treatment. The risk of trans...
Source: NHS News Feed - May 19, 2016 Category: Consumer Health News Tags: Neurology Medication Source Type: news

Surgical factors and complications affecting hospital outcome in redo mitral surgery: insights from a multicentre experience ADULT CARDIAC
CONCLUSIONS ReMVS still carries the risk of significant early mortality and major morbidity. Major lesion to cardiovascular structures is the most dreadful iatrogenic complication, and injury of a previous LIMA graft identifies patients at higher risk of operative mortality. Prolonged cross-clamp times, extracellular crystalloid cardioplegia and massive transfusions have profound impact on early outcome, as well as the development of perioperative AMI, eventually requiring IABP and prolonged intubation. The combination of antegrade and retrograde cardioplegia seems to offer a better myocardial protection in these high-risk patients.
Source: European Journal of Cardio-Thoracic Surgery - April 28, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Onorati, F., Perrotti, A., Reichart, D., Mariscalco, G., Della Ratta, E., Santarpino, G., Salsano, A., Rubino, A., Biancari, F., Gatti, G., Beghi, C., De Feo, M., Mignosa, C., Pappalardo, A., Fischlein, T., Chocron, S., Detter, C., Santini, F., Faggian, G Tags: Basic research vascular ADULT CARDIAC Source Type: research

Modeling and design of a cone-beam CT head scanner using task-based imaging performance optimization.
Abstract Detection of acute intracranial hemorrhage (ICH) is important for diagnosis and treatment of traumatic brain injury, stroke, postoperative bleeding, and other head and neck injuries. This paper details the design and development of a cone-beam CT (CBCT) system developed specifically for the detection of low-contrast ICH in a form suitable for application at the point of care. Recognizing such a low-contrast imaging task to be a major challenge in CBCT, the system design began with a rigorous analysis of task-based detectability including critical aspects of system geometry, hardware configuration, and art...
Source: Physics in Medicine and Biology - April 1, 2016 Category: Physics Authors: Xu J, Sisniega A, Zbijewski W, Dang H, Stayman JW, Wang X, Foos DH, Aygun N, Koliatsos VE, Siewerdsen JH Tags: Phys Med Biol Source Type: research

Evaluation of an anatomic definition of non-aneurysmal perimesencephalic subarachnhoid hemorrhage
Conclusions Our anatomic definition of PSAH correlated with a low risk of brain aneurysm and was applied with excellent inter-observer agreement.
Source: Journal of NeuroInterventional Surgery - March 15, 2016 Category: Neurosurgery Authors: Wallace, A. N., Vyhmeister, R., Dines, J. N., Chatterjee, A. R., Kansagra, A. P., Viets, R., Whisenant, J. T., Moran, C. J., Cross, D. T., Derdeyn, C. P. Tags: Hemorrhagic stroke Source Type: research

Arrive: A retrospective registry of Indian patients with venous thromboembolism
Conclusion: Acute DVT alone was responsible for the substantial burden of VTE in Indian patients. Bleeding was not the limiting factor for anticoagulant treatment in most patients.
Source: Indian Journal of Critical Care Medicine - March 8, 2016 Category: Intensive Care Authors: Dhanesh R KamerkarM Joseph JohnSanjay C DesaiLiesel C DsilvaSadhna J Joglekar Source Type: research

Long-term Outcome After EndoVAC Hybrid Repair of Infected Vascular Reconstructions.
CONCLUSION: The EndoVAC technique is an alternative, less invasive, option for treatment of infected vascular reconstructions in selected cases, when neither traditional radical surgery, nor conservative simple negative pressure wound therapy are considered feasible or safe. The exact indications for this alternative hybrid treatment need to be established. PMID: 26944600 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - March 1, 2016 Category: Surgery Authors: Thorbjørnsen K, Djavani Gidlund K, Björck M, Kragsterman B, Wanhainen A Tags: Eur J Vasc Endovasc Surg Source Type: research

Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome
Conclusions Neoplasm events were infrequent during long-term DAPT after ACS, were associated with differential cancer-screening practices across regions, and the frequency of neoplasm detection was similar with prasugrel vs. clopidogrel. Trial registration ClinicalTrials.gov identifier: NCT00699998.
Source: European Heart Journal - January 21, 2016 Category: Cardiology Authors: Roe, M. T., Cyr, D. D., Eckart, D., Schulte, P. J., Morse, M. A., Blackwell, K. L., Ready, N. E., Zafar, S. Y., Beaven, A. W., Strickler, J. H., Onken, J. E., Winters, K. J., Houterloot, L., Zamoryakhin, D., Wiviott, S. D., White, H. D., Prabhakaran, D., Tags: Acute coronary syndromes Source Type: research

Antidepressant Use Is Associated With an Increased Risk of Developing Microbleeds Brief Reports
Conclusions— Antidepressant use was associated with an increased risk of developing microbleeds. Our results may support findings from previous clinical studies about increased intracranial and extracranial bleeding risk in antidepressant users.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Akoudad, S., Aarts, N., Noordam, R., Ikram, M. A., Tiemeier, H., Hofman, A., Stricker, B. H., Vernooij, M. W., Visser, L. E. Tags: Epidemiology, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Thrombosis Brief Reports Source Type: research

Novel Diagnostic and Monitoring Tools in Stroke: an Individualized Patient-Centered Precision Medicine Approach.
Authors: de Villiers S, Swanepoel A, Bester J, Pretorius E Abstract Central to the pathogenesis of ischaemic stroke are the normally protective processes of platelet adhesion and activation. Experimental evidence has shown that the ligand-receptor interactions in ischaemic stroke represent a thrombo-inflammatory cascade, which presents research opportunities into new treatment. However, as anti-platelet drugs have the potential to cause severe side effects in ischaemic stroke patients (as well as other vascular disease patients), it is important to carefully monitor the risk of bleeding and risk of thrombus in pati...
Source: Journal of Atherosclerosis and Thrombosis - December 23, 2015 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Left Atrial Appendage Remodeling After Lariat Left Atrial Appendage Ligation Original Articles
Conclusions— Incomplete LAA ligation after Lariat is common. However, the remodeled LAA cavity is dramatically reduced. Diminished cavity size and tightening of the LAA orifice may play a role in the reduction of thrombus formation.
Source: Circulation: Arrhythmia and Electrophysiology - December 15, 2015 Category: Cardiology Authors: Kreidieh, B., Rojas, F., Schurmann, P., Dave, A. S., Kashani, A., Rodriguez-Manero, M., Valderrabano, M. Tags: Arrhythmias, Remodeling, Computerized Tomography (CT), Cerebrovascular Disease/Stroke Original Articles Source Type: research

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