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Condition: Thrombocytopenia

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Total 366 results found since Jan 2013.

Anticoagulants for people hospitalised with COVID-19
CONCLUSIONS: When compared to a lower-dose regimen, higher-dose anticoagulants result in little to no difference in all-cause mortality and increase minor bleeding in people hospitalised with COVID-19 up to 30 days. Higher-dose anticoagulants possibly reduce pulmonary embolism, slightly increase major bleeding, may result in little to no difference in hospitalisation time, and may result in little to no difference in deep vein thrombosis, stroke, major adverse limb events, myocardial infarction, atrial fibrillation, or thrombocytopenia. Compared with no treatment, anticoagulants may reduce all-cause mortality but the evide...
Source: Cochrane Database of Systematic Reviews - March 4, 2022 Category: General Medicine Authors: Ronald Lg Flumignan Vinicius T Civile J éssica Dantas de Sá Tinôco Patricia If Pascoal Libnah L Areias Charbel F Matar Britta Tendal Virginia Fm Trevisani Álvaro N Atallah Luis Cu Nakano Source Type: research

Late-Onset Vaccine-Induced Immune Thombotic Thrombocytopenia (VITT) with Cerebral Venous Sinus Thrombosis
A previously healthy 42-year-old woman presented to the emergency department with acute onset fluent aphasia. Further clinical examination was unremarkable. Emergency computed tomography (CT) of the head showed two small intracranial hemorrhages of the left temporal lobe and a hyperdense cerebral sinus. CT venogram confirmed cerebral venous sinus thrombosis (CVST) of the left vein of Labb é and sigmoid and transversal sinus (Fig. 1). As the paramedic reported ChAdOx1 nCOV-19 (AZD1222) vaccination 2 weeks before, vaccine-induced thrombotic thrombocytopenia (VITT) was suspected and the patient was treated with intravenous ...
Source: Journal of Stroke and Cerebrovascular Diseases - January 27, 2022 Category: Neurology Authors: Maruan Saleh, Julian Zimmermann, Nils C. Lehnen, Bernd P ötzsch, Johannes M. Weller Tags: Case Report Source Type: research

Influence of Thrombocytopenia on the Outcome of Mechanical Thrombectomy in Patients with Acute Ischemic Stroke
Mechanical thrombectomy (MT) has become leading treatment option for acute ischemic stroke (AIS) due to large vessels occlusion (LVO). Platelet counts may affect outcome in patients with AIS or transient ischemic attack. The aim of our study was to determine the influence of thrombocytopenia on the safety and efficacy of MT in patients with AIS due to anterior circulation LVO.
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2022 Category: Neurology Authors: Mirjana Ždraljević, Tatjana Pekmezović, Predrag Stanarčević, Ivan Vukašinović, Ivana Berisavac, Marko Ercegovac, Filip Vitošević, Dragoslav Nestorović, Vladimir Cvetić, Višnja Padjen, Maja Stefanović- Budimkić, Tamara Švabić Medjedović, D Source Type: research

Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination-United States, December 2020 to August 2021
CONCLUSION: Thrombosis with thrombocytopenia syndrome is a rare but serious adverse event associated with Ad26.COV2.S vaccination. The different demographic characteristics of the 3 cases reported after mRNA-based COVID-19 vaccines and the much lower reporting rate suggest that these cases represent a background rate.PRIMARY FUNDING SOURCE: Centers for Disease Control and Prevention.PMID:35038274 | DOI:10.7326/M21-4502
Source: Annals of Internal Medicine - January 17, 2022 Category: Internal Medicine Authors: Isaac See Allison Lale Paige Marquez Michael B Streiff Allison P Wheeler Naomi K Tepper Emily Jane Woo Karen R Broder Kathryn M Edwards Ruth Gallego Andrew I Geller Kelly A Jackson Shashi Sharma Kawsar R Talaat Emmanuel B Walter Imo J Akpan Thomas L Ortel Source Type: research

Arterial intracranial thrombosis as the first manifestation of vaccine-induced immune thrombotic thrombocytopenia (VITT): a case report
We describe a severe case of vaccine-induced immune thrombotic thrombocytopenia (VITT) after the first dose of the ChAdOx1 nCoV-19 vaccine leading to massive ischemic stroke.MethodsA 42-year-old woman developed acute left hemiparesis (NIHSS 12) 9  days after the first vaccine dose.ResultsThe blood tests revealed low platelets (70 103/ μL) and severe increment of D-dimer (70,745 ng/mL FEU). Brain non-contrast computed tomography and multiphasic CT angiography demonstrated a right middle cerebral artery occlusion. The patient was treated with primary thrombectomy, steroids, immunoglobulin, and fondaparinux. Despite the tr...
Source: Neurological Sciences - January 13, 2022 Category: Neurology Source Type: research

Delayed diagnosis of congenital thrombotic thrombocytopenic purpura in a patient with recurrent strokes
AbstractCongenital thrombotic thrombocytopenic purpura (cTTP) is caused by ADAMTS13 mutations and associated with high risk of microvascular thrombosis. A 58  year old female had an ischemic stroke during hormonal fertility, and a TIA a year after. She suffered another stroke 18 years later while on warfarin. Four months after she developed severe thrombocytopenia, mild anemia, and increased LDH. Blood film showed schistocytes. She was hospitalized wit h presumptive TTP. ADAMTS 13 activity was undetectable without inhibitor. She developed another stroke and received plasma exchange. A homozygote ADAMTS 13 mutation was id...
Source: Journal of Thrombosis and Thrombolysis - January 12, 2022 Category: Hematology Source Type: research

Glycoprotein V : the unsolved GPV puzzle
Platelets. 2022 Jan 7:1-8. doi: 10.1080/09537104.2021.2022114. Online ahead of print.ABSTRACTGlycoprotein V (GPV) is a highly expressed 82 KDa platelet surface transmembrane protein which is loosely attached to the GPIb-IX complex. Despite remaining questions concerning its function, GPV presents several unique features which have repercussions in hematology, atherothrombosis, immunology and transfusion. GPV is specifically expressed in platelets and megakaryocytes and is an ideal marker and reporter gene for the late stages of megakaryopoiesis. The ectodomain of GPV can be released by a number of proteases, namely thrombi...
Source: Platelets - January 7, 2022 Category: Hematology Authors: Quentin Kimmerlin Sylvie Moog Catherine Ravanat Catherine Strassel Fran çois Lanza Source Type: research

Acute Thrombocytopenia is More Pronounced in Women After LVAD Implantation
The alterations of platelet count in patients undergoing left ventricular assist device (LVAD) implantation are unkonown. We characterized differences in platelet count between men and women with a “benign” course post LVAD in the absence of stroke, sepsis, the need for other mechanical circulatory support, renal replacement therapy, and prolonged vasopressor support. After Institutional Review Board approval, we retrospectively studied consecutive patients undergoing Heart Mate 2 or 3 imp lantation from April, 2008 until August, 2020.
Source: Journal of Cardiothoracic and Vascular Anesthesia - January 7, 2022 Category: Anesthesiology Authors: Assi Milwidsky, Magued W. Haroun, Shivank Madan, Omar Saeed, Ari Feinberg, Seyed F. Marashi, Mayuko Uehara, Stephen J. Forest, Daniel J. Goldstein, Ulrich. P. Jorde Source Type: research

Cancers, Vol. 14, Pages 118: Percutaneous Hepatic Perfusion (PHP) with Melphalan in Liver-Dominant Metastatic Uveal Melanoma: The German Experience
In conclusion, PHP is a safe and effective salvage treatment for liver-dominant metastatic uveal melanoma. Serious AEs—though rare—demand careful patient selection.
Source: Cancers - December 27, 2021 Category: Cancer & Oncology Authors: Cornelia L. A. Dewald Mia-Maria Warnke Roland Br üning Martin A. Schneider Peter Wohlmuth Jan B. Hinrichs Anna Saborowski Arndt Vogel Frank K. Wacker Tags: Article Source Type: research

Transfusion thresholds for guiding red blood cell transfusion
CONCLUSIONS: Transfusion at a restrictive haemoglobin concentration decreased the proportion of people exposed to RBC transfusion by 41% across a broad range of clinical contexts. Across all trials, no evidence suggests that a restrictive transfusion strategy impacted 30-day mortality, mortality at other time points, or morbidity (i.e. cardiac events, myocardial infarction, stroke, pneumonia, thromboembolism, infection) compared with a liberal transfusion strategy. Despite including 17 more randomised trials (and 8846 participants), data remain insufficient to inform the safety of transfusion policies in important and sele...
Source: Cochrane Database of Systematic Reviews - December 21, 2021 Category: General Medicine Authors: Jeffrey L Carson Simon J Stanworth Jane A Dennis Marialena Trivella Nareg Roubinian Dean A Fergusson Darrell Triulzi Carolyn Dor ée Paul C H ébert Source Type: research

Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia
CONCLUSIONS: Vaccine-induced immune thrombotic thrombocytopenia is a serious complication of vaccination that is not feasible to anticipate or prevent. When the patient presents with sustained headache, neurologic symptoms/signs, abdominal pain, dyspnea, or limb pain/swelling beginning 5–30 days post vaccination, platelet count and d-dimer must be measured, and imaging for thrombosis performed. Confirmation of vaccine-induced immune thrombotic thrombocytopenia diagnosis should be ordered (platelet factor 4/polyanion enzyme-linked immunosorbent assay; platelet factor 4–enhanced platelet activation testing) as treatm...
Source: Critical Care Medicine - December 20, 2021 Category: Emergency Medicine Tags: Online Review Article Source Type: research