Late-Onset Vaccine-Induced Immune Thombotic Thrombocytopenia (VITT) with Cerebral Venous Sinus Thrombosis

A previously healthy 42-year-old woman presented to the emergency department with acute onset fluent aphasia. Further clinical examination was unremarkable. Emergency computed tomography (CT) of the head showed two small intracranial hemorrhages of the left temporal lobe and a hyperdense cerebral sinus. CT venogram confirmed cerebral venous sinus thrombosis (CVST) of the left vein of Labb é and sigmoid and transversal sinus (Fig. 1). As the paramedic reported ChAdOx1 nCOV-19 (AZD1222) vaccination 2 weeks before, vaccine-induced thrombotic thrombocytopenia (VITT) was suspected and the patient was treated with intravenous immunoglobulins (1 g/kg over 2 days) and argatroban.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Case Report Source Type: research