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Low immunoglobulin levels affect the course of COPD in hospitalized patients
Chronic obstructive pulmonary disease (COPD) affects up to 10% of Canadians. Patients with COPD may present with secondary humoral immunodeficiency as a result of chronic disease, poor nutrition or frequent co...
Source: Allergy, Asthma and Clinical Immunology - January 29, 2023 Category: Allergy & Immunology Authors: Nami Shrestha Palikhe, Malcena Niven, Desi Fuhr, Tristan Sinnatamby, Brian H. Rowe, Mohit Bhutani, Michael K. Stickland and Harissios Vliagoftis Tags: Research Source Type: research

Primary care provider diagnosed eczema within electronic medical records from seven canadian provinces
CONCLUSION: This is the first study in Canada to determine the prevalence of primary care provider documented eczema using EMR data. This study can inform and improve disease surveillance as well as future studies exploring burden of illness, trends or interventions related to eczema care in Canada.PMID:35881493 | DOI:10.1370/afm.20.s1.2895
Source: Annals of Family Medicine - July 26, 2022 Category: Primary Care Authors: Hannah Stirton Leanne Kosowan John Queenan Alan Katz Alexander Singer Jennifer Protudjer Elissa Abrams Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Population-based case-finding to identify subjects with undiagnosed asthma or COPD
Conclusion 20% of randomly selected individuals who report respiratory symptoms in Canada have undiagnosed airflow obstruction due to asthma or COPD. Questionnaires could exclude subjects at low risk but lack the ability to accurately find subjects with undiagnosed disease.
Source: European Respiratory Journal - June 17, 2020 Category: Respiratory Medicine Authors: Preteroti, M., Whitmore, G. A., Vandemheen, K. L., FitzGerald, J. M., Lemiere, C., Boulet, L.-P., Penz, E., Field, S. K., Gupta, S., McIvor, R. A., Mayers, I., Hernandez, P., Lougheed, D., Ainslie, M., Licskai, C., Azher, T., Fraser, I., Mahdavian, M., Aa Tags: COPD and smoking, Asthma and allergy Original Articles: Asthma and COPD Source Type: research

Risk Factors for Return to the Emergency Department for Asthma: A Population-Based Study
ConclusionsNearly 1 in 8 individuals with a first ED visit for asthma returned to the ED within a year of the initial ED discharge. Targeting those at risk for ED return may help improve health care costs, productivity, and quality of life.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Electronic Cigarettes: Their Constituents and Potential Links to Asthma
AbstractPurpose of ReviewVaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig ...
Source: Current Allergy and Asthma Reports - October 5, 2017 Category: Allergy & Immunology Source Type: research

Residential Air Pollution and Associations with Wheeze and Shortness of Breath in Adults: A Combined Analysis of Cross-Sectional Data from Two Large European Cohorts
Conclusion: Exposure to PM and NO2 air pollution was associated with the prevalence of wheeze and shortness of breath in this large study, with stronger associations between PM2.5 and both outcomes among lower- versus higher-income participants. https://doi.org/10.1289/EHP1353 Received: 13 November 2016 Revised: 10 August 2017 Accepted: 14 August 2017 Published: 29 September 2017 Address correspondence to D. Doiron, Research Institute of the McGill University Health Centre, 2155 rue Guy, office 458, Montreal, Canada, H3H 2R9. Telephone: 1-514-934-1934 (ex. 71688). Email: ddoiron@maelstrom-research.org Supplemental Ma...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Do community demographics, environmental characteristics and access to care affect risks of developing ACOS and mortality in people with asthma?
Individuals with asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) have a more rapid decline in lung function, more frequent exacerbations and worse quality of life than those with asthma or COPD alone [1–3]. Various risk factors may be associated with the development of ACOS, such as smoking history and status, obesity, comorbidity and indoor and outdoor environmental exposures [1, 4–6]. The risk of developing ACOS may vary substantially by region, since demographic and environmental risk factors and community characteristics are not geographically homogeneous. Here, we use popula...
Source: European Respiratory Journal - September 11, 2017 Category: Respiratory Medicine Authors: To, T., Zhu, J., Carlsten, C., Larsen, K., Ryckman, K., Feldman, L. Y., Crighton, E., Lougheed, M. D., Licskai, C., Villeneuve, P. J., Su, Y., Sadatsafavi, M., Gershon, A., for the Canadian Respiratory Research Network Tags: COPD and smoking, Asthma and allergy Original Articles: Research letters Source Type: research