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Specialty: Hematology
Condition: Anemia
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Total 197 results found since Jan 2013.
A comparison of red blood cell transfusion utilization between anti-factor Xa and activated partial thromboplastin monitoring in patients receiving unfractionated heparin.
CONCLUSION: Anti-Xa was associated with a significant reduction in RBC transfusions when compared to patients monitored by aPTT alone. This article is protected by copyright. All rights reserved.
PMID: 27543785 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 19, 2016 Category: Hematology Authors: Belk KW, Laposata M, Craver C Tags: J Thromb Haemost Source Type: research
Hydroxycarbamide treatment and brain MRI/MRA findings in children with sickle cell anaemia
Summary
Silent cerebral infarction (SCI) is the most common neurological abnormality among children with sickle cell anaemia (SCA). The effect of hydroxycarbamide (also termed hydroxyurea) on the development and progression of SCI is unclear. We evaluated brain magnetic resonance imaging/angiography (MRI/MRA) in children with SCA receiving long‐term hydroxycarbamide therapy. Fifty participants (median 9·4 years, range 1·1–17·3) enrolled in the Hydroxyurea Study of Long‐Term Effects (HUSTLE; NCT00305175) underwent brain MRI/MRA and laboratory evaluations before hydroxycarbamide initiation and after 3 and 6 years ...
Source: British Journal of Haematology - September 7, 2016 Category: Hematology Authors: Kerri A. Nottage, Russell E. Ware, Banu Aygun, Matthew Smeltzer, Guolian Kang, Joseph Moen, Winfred C. Wang, Jane S. Hankins, Kathleen J. Helton Tags: Research Paper Source Type: research
Stroke in sickle cell anaemia is more than stenosis and thrombosis: the role of anaemia and hyperemia in ischaemia
Source: British Journal of Haematology - November 10, 2016 Category: Hematology Authors: Michael M. Dowling, Fenella J. Kirkham Tags: Editorial Comment Source Type: research
The severity of anaemia depletes cerebrovascular dilatory reserve in children with sickle cell disease: a quantitative magnetic resonance imaging study
Summary
Overt ischaemic stroke is one of the most devastating complications in children with sickle cell disease (SCD). The compensatory response to anaemia in SCD includes an increase in cerebral blood flow (CBF) by accessing cerebrovascular dilatory reserve. Exhaustion of dilatory reserve secondary to anaemic stress may lead to cerebral ischaemia. The purpose of this study was to investigate CBF and cerebrovascular reactivity (CVR) using magnetic resonance imaging (MRI) in children with SCD and to correlate these with haematological markers of anaemia. Baseline CBF was measured using arterial spin labelling. Blood‐oxyg...
Source: British Journal of Haematology - November 30, 2016 Category: Hematology Authors: Przemyslaw D. Kosinski, Paula L. Croal, Jackie Leung, Suzan Williams, Isaac Odame, Gregory M. T. Hare, Manohar Shroff, Andrea Kassner Tags: Research Paper Source Type: research
Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.
CONCLUSION: Implementation of a unique, jurisdiction-wide PBM program was associated with improved patient outcomes, reduced blood product utilization, and product-related cost savings.
PMID: 28150313 [PubMed - as supplied by publisher]
Source: Transfusion - February 1, 2017 Category: Hematology Authors: Leahy MF, Hofmann A, Towler S, Trentino KM, Burrows SA, Swain SG, Hamdorf J, Gallagher T, Koay A, Geelhoed GC, Farmer SL Tags: Transfusion Source Type: research
Comprehensive neuropsychological evaluation of children and adolescents with sickle cell anemia: a hospital-based sample
Conclusion: As sickle cell anemia is considered a progressive cerebral vasculopathy, it is a potential risk factor for neurocognitive and psychosocial development. Therefore, periodic neuropsychological and behavioral evaluations of children and adolescents with sickle cell anemia may represent a useful measure to reduce long-term biopsychosocial repercussions.
Source: Revista Brasileira de Hematologia e Hemoterapia - April 3, 2017 Category: Hematology Source Type: research
Interleukin ‐6 G‐174C polymorphism predicts higher risk of stroke in sickle cell anaemia
Source: British Journal of Haematology - May 1, 2017 Category: Hematology Authors: Igor F. Domingos, Diego A. Pereira ‐Martins, Juan L. Coelho‐Silva, Rayssa L. Borges‐Medeiros, Diego A. Falcão, Renata C. Azevedo, Ana C. Anjos, Fernando F. Costa, Taciana F. Mendonça, Maria S. Cavalcanti, Aderson S. Araujo, Antonio R. Lucena‐Ara Tags: Correspondence Source Type: research
Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia
Conclusion: Interleukin-10 haplotypes were not associated with the risk of acute cerebral ischemia or high-risk transcranial Doppler velocity in children with sickle cell anemia from the state of Minas Gerais, Brazil.
Source: Revista Brasileira de Hematologia e Hemoterapia - July 3, 2017 Category: Hematology Source Type: research
Pattern of cerebral blood flow velocity using transcranial Doppler ultrasonography in children with sickle cell disorder in Lagos State, Nigeria
Conclusion: The prevalence of abnormal TAMM velocity is high in children with HbSS. The need for availability of and accessibility to transcranial Doppler screening is emphasized.
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 13, 2017 Category: Hematology Source Type: research
Degree of anemia, indirect markers of hemolysis, and vascular complications of sickle cell disease in Africa
In conclusion, severe anemia at steady state in SCD patients living in West and Central Africa is associated with elevated TRV, microalbuminuria, and leg ulcers, but these vascular complications are not independently associated with indirect markers of increased hemolysis. Other mechanisms leading to anemia, including malnutrition and infectious diseases, may also play a role in the development of SCD vasculopathy.
Source: Blood - November 16, 2017 Category: Hematology Authors: Dubert, M., Elion, J., Tolo, A., Diallo, D. A., Diop, S., Diagne, I., Sanogo, I., Belinga, S., Guifo, O., Wamba, G., Ngo Sack, F., Boidy, K., Kamara, I., Traore, Y., Diakite, C. O., Gbonon, V., Faye, B. F., Seck, M., Deme Ly, I., Chelo, D., NGuetta, R., D Tags: Sickle Cell Disease, Red Cells, Iron, and Erythropoiesis Source Type: research
The clinical epidemiology of sickle cell anemia in Africa
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - November 23, 2017 Category: Hematology Authors: Alex W Macharia, George Mochamah, Sophie Uyoga, Carolyne M Ndila, Gideon Nyutu, Johnstone Makale, Metrine Tendwa, Emily Nyatichi, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, J Anthony G Scott, Kathryn Maitland Tags: Research Article Source Type: research
Realizing Effectiveness Across Continents with Hydroxyurea: Enrollment and Baseline Characteristics of the Multicenter REACH Study in sub ‐Saharan Africa
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - January 10, 2018 Category: Hematology Authors: Patrick T. McGann, Thomas N. Williams, Peter Olupot ‐Olupot, George A. Tomlinson, Adam Lane, José Luís Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Thad A. Howard, Kathryn McElhinney, Banu Aygun, Teresa Latham, Brígida Tags: Research Article Source Type: research
Factor V Leiden G1691A and prothrombin G20210A mutations among Palestinian patients with sickle cell disease
ConclusionsFVL was more prevalent among SS patients compared to controls and it was associated with higher incidence of disease complications among SCD patients.
Source: BMC Hematology - January 16, 2018 Category: Hematology Source Type: research
Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Najibah A. Galadanci, Shehu Umar Abdullahi, Leah D. Vance, Abdulkadir Musa Tabari, Shehi Ali, Raymond Belonwu, Auwal Salihu, Aisha Amal Galadanci, Binta Wudil Jibir, Halima Bello ‐Manga, Kathleen Neville, Fenella J. Kirkham, Yu Shyr, Sharon Phillips, Br Tags: ERRATUM Source Type: research
Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature
AbstractThis case report describes agranulocytosis immediately after oral administration of dabigatran in a 68 years old man with atrial fibrillation (AF). Dabigatran is an oral, reversible and competitive thrombin inhibitor that has shown promising results. In patients with atrial fibrillation of RE-LY study (Randomized Evaluation of Long-Term Anticoagulant Therapy), dabigatran administered at a dose of 1 50 mg, as compared with warfarin, was associated with lower rates of stroke and systemic embolism but similar rates of major hemorrhage. Dabigatran is administered as a prodrug and the peak of the plasma concentration...
Source: Journal of Thrombosis and Thrombolysis - February 5, 2018 Category: Hematology Source Type: research
