Filtered By:
Condition: Alzheimer's
Drug: Melatonin
This page shows you your search results in order of date.
Order by Relevance | Date
Total 108 results found since Jan 2013.
Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice
CONCLUSIONS: Melatonin receptors in SCN, circadian rhythm, and ERK/CREB signaling pathway participate in the pathophysiological processes of PSD and delirium-like behavior. Melatonin intervention could be a potential preventative approach for PSD and delirium.PMID:37736695 | DOI:10.1111/cns.14436
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xixi Jia Yanan Song Zhengqian Li Ning Yang Taotao Liu Dengyang Han Zhuonan Sun Chengmei Shi Yang Zhou Jie Shi Yajie Liu Xiangyang Guo Source Type: research
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
Arch Toxicol. 2023 Aug 19. doi: 10.1007/s00204-023-03562-9. Online ahead of print.ABSTRACTA physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or "good stress" and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2-related factor ...
Source: Archives of Toxicology - August 19, 2023 Category: Toxicology Authors: Klaudia Jomova Renata Raptova Suliman Y Alomar Saleh H Alwasel Eugenie Nepovimova Kamil Kuca Marian Valko Source Type: research
Yet another < em > in vitro < /em > evidence that natural compounds introduced by diet have anti-amyloidogenic activities and can counteract neurodegenerative disease depending on aging
Nat Prod Res. 2023 Mar 24:1-6. doi: 10.1080/14786419.2023.2192493. Online ahead of print.ABSTRACTA major issue in Alzheimer's disease (AD) research is to find some new therapeutic drug which decrease Amyloid-beta (Aβ) aggregation. From a therapeutic point of view the major question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. Natural compounds are capable of binding to different targets implicated in AD and exert neuroprotective effects. Aim of this study was to evaluate the in vitro inhibition of Aβ1-42 fibrillogenesis in presence of Gallic ...
Source: Natural Product Research - March 25, 2023 Category: Biochemistry Authors: Anna Lia Asti Stefania Crespi Teresa Rampino Paola Zelini Marilena Gregorini Alessia Pascale Nicoletta Marchesi Stefania Saccucci Carla Colombani Sara Vitalini Marcello Iriti Source Type: research
Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer's Disease
Curr Neuropharmacol. 2023 Mar 14. doi: 10.2174/1570159X21666230314142505. Online ahead of print.ABSTRACTThe synthesis and release of melatonin in the brain harmonize various physiological functions. The apparent decline in melatonin levels with advanced aging is an aperture to the neurodegenerative processes. It has been indicated that down regulation of melatonin leads to alterations of circadian rhythm components, which further causes a desynchronization of several genes and results in an increased susceptibility to develop neurodegenerative diseases. Additionally, as circadian rhythms and memory are intertwined, such rh...
Source: Current Neuropharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Mayuri Shukla Bruno Vincent Source Type: research
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm
Cell Mol Life Sci. 2023 Mar 14;80(4):88. doi: 10.1007/s00018-023-04736-5.ABSTRACTThe brain lacks a classic lymphatic drainage system. How it is cleansed of damaged proteins, cellular debris, and molecular by-products has remained a mystery for decades. Recent discoveries have identified a hybrid system that includes cerebrospinal fluid (CSF)-filled perivascular spaces and classic lymph vessels in the dural covering of the brain and spinal cord that functionally cooperate to remove toxic and non-functional trash from the brain. These two components functioning together are referred to as the glymphatic system. We propose th...
Source: Cellular and Molecular Life Sciences : CMLS - March 14, 2023 Category: Cytology Authors: Russel J Reiter Ramaswamy Sharma Maira Smaniotto Cucielo Dun Xian Tan Sergio Rosales-Corral Giuseppe Gancitano Luiz Gustavo de Almeida Chuffa Source Type: research
Mechanism of action and therapeutic effects of oxidative stress and stem cell-based materials in skin aging: Current evidence and future perspectives
Front Bioeng Biotechnol. 2023 Jan 9;10:1082403. doi: 10.3389/fbioe.2022.1082403. eCollection 2022.ABSTRACTAging is associated with multiple degenerative diseases, including atherosclerosis, osteoporosis, and Alzheimer's disease. As the most intuitive manifestation of aging, skin aging has received the most significant attention. Skin aging results from various intrinsic and extrinsic factors. Aged skin is characterized by wrinkles, laxity, elastosis, telangiectasia, and aberrant pigmentation. The underlying mechanism is complex and may involve cellular senescence, DNA damage, oxidative stress (OS), inflammation, and geneti...
Source: Atherosclerosis - January 26, 2023 Category: Cardiology Authors: Huan Qian Yihan Shan Ruicheng Gong Danfeng Lin Mengwen Zhang Chen Wang Lu Wang Source Type: research
Regulatory role of melatonin in Notch1 signaling pathway in cerebral cortex of A β < sub > 1-42 < /sub > -induced Alzheimer's disease rat model
CONCLUSION: This observation suggests that targeting of Notch1 signaling might be a promising therapeutic approach for AD and other age-associated neurodegenerative diseases, and melatonin might serve as a potential therapeutic agent for AD and other age-associated neurodegenerative diseases.PMID:36602704 | DOI:10.1007/s11033-022-08213-3
Source: Molecular Biology Reports - January 5, 2023 Category: Molecular Biology Authors: Pan Wang Shuman Zhang Chunli Hu Lili Ren Jing Bi Source Type: research
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Dual functional antioxidant and butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of novel melatonin-alkylbenzylamine hybrids
Bioorg Med Chem. 2022 Dec 24;78:117146. doi: 10.1016/j.bmc.2022.117146. Online ahead of print.ABSTRACTHere, we have designed and synthesized a series of melatonin-alkylbenzylamine hybrids as multitarget agents for the treatment of Alzheimer's disease (AD). Most of them exhibited a potent multifunctional profile involving cholinesterase inhibition and antioxidant effects. Among these compounds, compound 5 was most the potent antioxidant (ORAC = 5.13) and also an excellent selective inhibitor of BuChE (huBuChE IC50 = 1.20 μM, huAChE IC50 = 177.49 μM, SI = 147.91). Moreover, kinetic study indicated compound 5 was a mixed-ty...
Source: Bioorganic and Medicinal Chemistry - December 29, 2022 Category: Chemistry Authors: Peng Liu Maojun Cheng Jie Guo Duanyuan Cao Jinchong Luo Yang Wan Yuanying Fang Yi Jin Sai-Sai Xie Jing Liu Source Type: research
