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Total 665 results found since Jan 2013.

Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. Additions and Corrections
This article has been retracted by the publisher. An investigation at MD Anderson determined that image of control HCT116 cells treated with TRAIL and the image of cells transfected with CHOP siRNA and treated with TRAIL in Fig. 5C were reused. Additionally, the Journal determined that the actin immunoblot in Fig. 2A was reused as the actin immunoblot in Fig. 3B; the control/TRAIL treated image had been reused in the DR5/Gossypol+TRAIL and in the scrambled siRNA/TRAIL images in Fig. 4B; the scrambled siRNA/Gossypol image from Fig. 4B was reused as the NAC image in Fig. 7C; and the control/Gossypol image was reused as the C...
Source: Journal of Biological Chemistry - August 4, 2016 Category: Chemistry Authors: Sung, B., Ravindran, J., Prasad, S., Pandey, M. K., Aggarwal, B. B. Tags: Additions and Corrections Source Type: research

5-Azacytidine suppresses EC9706 cell proliferation and metastasis by upregulating the expression of SOX17 and CDH1.
In this study, using Transwell invasion and cell proliferation assays, we demonstrated that 5-azacytidine significantly inhibited the metastasis and proliferation of EC9706 cells, and upregulated the expression of cadherin 1 (CDH1) and SRY-box containing gene 17 (SOX17). Moreover, the inhibition of the metastasis of the 5-azacytidine-treated EC9706 cells was impaired following transfection with siRNA targeting CDH1 (CDH1 siRNA), and the inhibition of cell proliferation was attenuated following the downregulation of SOX17 by siRNA targeting SOX17 (SOX17 siRNA). Furthermore, 5-azacytidine remarkably reduced the CDH1 ...
Source: International Journal of Molecular Medicine - August 10, 2016 Category: Molecular Biology Authors: Li W, Wu D, Niu Z, Jiang D, Ma H, He H, Zuo X, Xie X, He Y Tags: Int J Mol Med Source Type: research

Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells.
Authors: Wang H, Li S, Luo X, Song Z, Long X, Zhu X Abstract Colorectal adenocarcinoma is the third most common cancer worldwide. PARP6, a novel member of the poly(ADP-ribose) polymerases (PARPs) and survivin, a member of the family of inhibitor of apoptosis (IAP) proteins are associated with a poor prognosis in various types of cancers. However, limited evidence exists regarding the interaction between PARP6 and survivin in colorectal adenocarcinoma. In the present study, we used the paired samples of 20 patients with colorectal adenocarcinoma to detect the expression of PARP6 and survivin in both tumor and adjac...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer
ConclusionThe silencing CXCL12 gene significantly inhibits the proliferation, invasion and angiogenesis ability of some types colon carcinoma cells through down-regulation of MAPK/PI3K/AP-1 signaling pathway.
Source: Clinical and Translational Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma.
Authors: Bi C, Jiang B Abstract The morbidity of colorectal cancer (CRC) increases annualy, which accounts to higher mortality worldwide. Therefore, it is important to study the pathogenesis of colon cancer. Ribophorin II (RPN2), part of the N-oligosaccharyltransferase complex, is highly expressed in CRC. In the present study, we investigated whether RPN2 can regulate apoptosis, migration and invasion by RNA interference in CRC and sought to clarify the molecular mechanism involved. Based on previous research, an abnormal high expression of RPN2 was observed in CRC tissues and cell lines by real-time (RT)-PCR, im...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLC γ.
TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ. Oncol Rep. 2019 Jan 30;: Authors: Zhang X, Shi G, Gao F, Liu P, Wang H, Tan X Abstract Pancreatic cancer (PC), a malignancy of the digestive system, has one of the highest rates of metastasis and mortality. It is characterized by the detachment, migration, implantation and infiltration of tumor cells to form metastases or recurrent foci. Tetraspanin 1 (TSPAN1), a novel member of the TSPAN superfamily, is highly expressed in many types of cancer, including gastric, colon, liver and esophageal cancer. It has also ...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

β-Carotene 15,15'-monooxygenase 1 and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells.
Conclusions: Inhibition of BCMO1 expression is associated with increased invasiveness of colon cancer cells and increased expression of MMP7 and MMP28. β-Carotene can upregulate BCMO1 and reverse these effects. These novel associations suggest a critical role for BCMO1 in cancer and provide a mechanism for the proposed antitumor effects of β-carotene. PMID: 23803888 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - June 26, 2013 Category: Nutrition Authors: Pham DN, Leclerc D, Lévesque N, Deng L, Rozen R Tags: Am J Clin Nutr Source Type: research

Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth
Conclusions: Silencing GRP78 not only inhibits tumor, but also decreases the expression of VEGF and VEGFR2. Collectively, therapy targeting for GRP78 may inhibit the formation of colon cancer tumors via the HIF-1α/VEGF/VEGFR2 pathway.
Source: Journal of Surgical Research - May 30, 2013 Category: Surgery Authors: Li-Jen Kuo, Chin-Sheng Hung, Wei-Yu Chen, Yu-Jia Chang, Po-Li Wei Tags: Oncology/Endocrine Source Type: research

BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production.
Abstract We screened a chemical library in MCF-7 cells stably expressing green fluorescent protein (GFP)-conjugated microtubule-associated protein 1 light chain 3 (LC3) (GFP-LC3-MCF-7) using cell-based assay, and identified BIX-01294 (BIX), a selective inhibitor of euchromatic histone-lysine N-methyltransferase 2 (EHMT2), as a strong autophagy inducer. BIX enhanced formation of GFP-LC3 puncta, LC3-II, and free GFP, signifying autophagic activation. Inhibition of these phenomena with chloroquine and increasement in punctate dKeima ratio (550/438) signal indicated that BIX activated autophagic flux. BIX-induced cell...
Source: Autophagy - December 1, 2013 Category: Cytology Authors: Kim Y, Kim YS, Kim DE, Lee JS, Song JH, Kim HG, Cho DH, Jeong SY, Jin DH, Jang SJ, Seol HS, Suh YA, Lee SJ, Kim CS, Koh JY, Hwang JJ Tags: Autophagy Source Type: research

Wnt9A Expression Increased by Decline in Arylsulfatase B Molecular Bases of Disease
In this study, the novel transcriptional mechanism by which carrageenan and decline in ARSB increase Wnt9A expression in NCM460 and HT-29 human colonic epithelial cells and in mouse colon is presented. Increased expression of Wnt9A has been associated with multiple malignancies, including colon carcinoma, and with ectodermal and mesoendodermal morphogenesis. When ARSB activity was reduced by siRNA or by exposure to carrageenan (1 μg/ml for 24 h), degradation of chondroitin 4-sulfate (C4S) was inhibited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a β-galactoside-binding protein. Nucl...
Source: Journal of Biological Chemistry - June 19, 2014 Category: Chemistry Authors: Bhattacharyya, S., Feferman, L., Tobacman, J. K. Tags: Glycobiology and Extracellular Matrices Source Type: research

1643p * y-box binding protein-1 is involved in tumor angiogenesis and a promising therapeutic target
Conclusions: These results suggest that YB-1 is a key factor for angiogenesis and may be a promising target for the treatment of refractory malignancies.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Shinkai, K., Nakano, K., Onishi, H., Tanaka, M., Katano, M. Tags: tumour biology and pathology Source Type: research

Abstract 779: Osteopontin gene expression is associated with 5-fluorouracil drug resistance in colon cancer
Background: Resistance to chemotherapeutic drugs complicates the treatment of cancer patients. The extracellular matrix protein osteopontin (OPN) plays multiple roles in the proliferation and metastasis of cancer cells. We therefore attempted to determine whether OPN expression correlated with drug resistance. Methods: OPN expression in the HCT 116 colon cancer cell line was inhibited by an OPN-short interfering RNA (siRNA). We determined the cytotoxic effect (IC50) of 5-fluorouracil (5FU) on these cells. Patients with recurrence or colorectal cancer or harbored residual tumor cells were treated with S-1-based chemotherapy...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Nakajima, G., Kuramochi, H., Yamamoto, M., Hayashi, K. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 2730: RNAi knockdown or chemical inhibition of anaphase-promoting complex components is synthetic lethal with HSP90 inhibition
The molecular chaperone heat shock protein 90 (HSP90) maintains the conformation, stability and function of oncogenic client proteins, many of which are mutated or overexpressed. Therefore, HSP90 is an important cancer therapeutic target. To further increase the efficacy of HSP90 inhibitors, combinatorial therapeutic strategies may be beneficial. Here we report an unbiased global screening approach to identify genes that encode potentially druggable proteins that modulate cellular responses to HSP90 inhibition. From the 7,593 genes that were tested, three components of the anaphase-promoting complex (APC/C) were among the ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Howes, J., Lu, B.-F., Powers, M., Mitsopoulos, C., Al-Lazikani, B., Linardopoulos, S., Clarke, P., Workman, P. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 5382: A breakthrough in application of a drug delivery nanoparticle system for therapy and diagnosis of solid tumor
Conclusion: Our data suggest that sCA itself, while designed as an in vivo delivery device, can facilitate entrance of low molecular chemicals into tumor cells in vitro and in vivo. Citation Format: Xin Wu, Hirofumi Yamamoto, Mamoru Uemura, Taishi Hata, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori. A breakthrough in application of a drug delivery nanoparticle system for therapy and diagnosis of solid tumor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wu, X., Yamamoto, H., Uemura, M., Hata, T., Nishimura, J., Takemasa, I., Mizushima, T., Doki, Y., Mori, M. Tags: Cancer Chemistry Source Type: research

Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy
Abstract It is well known that both eukaryotic initiation factor 4E (eIF4E) and integrin αvβ6 can contribute to malignant behavior of colon cancer. We have found that integrin αvβ6 and eIF4E were co-expressed and positively correlated in colon cancer tissues. Recently, deregulation of the protein synthesis apparatus has begun to gain attention as a major participant in cancer development and progression. However, the regulation of integrin β6 expression at translational level has never been investigated before. In present study, gene-silencing technique for eIF4E by small interfering RNA (siRNA) was used in a...
Source: Tumor Biology - May 17, 2015 Category: Cancer & Oncology Source Type: research