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Remote Activation of Enzyme Nanohybrids for Cancer Prodrug Therapy Controlled by Magnetic Heating
ACS Nano. 2023 Jun 26. doi: 10.1021/acsnano.3c01599. Online ahead of print.ABSTRACTHerein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic nanoparticles (MNPs) with horseradish peroxidase (HRP) using biomimetic silica as an entrapment matrix was optimized to obtain nanosized hybrids (∼150 nm) for remote activation of the therapeutic enzyme. HRP converts indole-3-acetic acid (3IAA) into peroxylated radicals, whereas MNPs respond to alternating magnetic fields (AMFs) becoming local hotspots. The AMF applicat...
Source: Cancer Control - June 26, 2023 Category: Cancer & Oncology Authors: Beatriz Torres-Herrero Ilaria Armenia Maria Alleva Laura As ín Sonali Correa Cecilia Ortiz Yilian Fern ández-Afonso Luc ía Gutiérrez Jes ús M de la Fuente Lorena Betancor Valeria Graz ú Source Type: research

In Situ Formed ROS-responsive Hydrogel with STING Agonist and Gemcitabine to Intensify immunotherapy Against Pancreatic Ductal Adenocarcinoma
This article is protected by copyright. All rights reserved.PMID:36971070 | DOI:10.1002/adhm.202203264
Source: Adv Data - March 27, 2023 Category: Epidemiology Authors: Meng Wang Qida Hu Junming Huang Fu Zhang Zhuo Yao Shiyi Shao Xinyu Zhao Tingbo Liang Source Type: research

Multifunctional Low-Generation Dendrimer Nanogels as an Emerging Probe for Tumor-Specific CT/MR Dual-Modal Imaging
Biomacromolecules. 2023 Jan 6. doi: 10.1021/acs.biomac.2c01403. Online ahead of print.ABSTRACTThe development of nanoprobes that have amplified enhanced permeability and retention (EPR) effect is crucial for their precise cancer diagnosis performance. Here, we present the development of functional dendrimer-based nanogels (DNGs) with the generation three primary amine-terminated poly(amidoamine) (PAMAM) dendrimers (G3·NH2) cross-linked by N,N'-bis(acryloyl) cystamine (BAC). The DNGs were prepared through a Michael addition reaction between G3·NH2 dendrimers and BAC via an inverse microemulsion method and entrapped with g...
Source: Biomacromolecules - January 6, 2023 Category: Biochemistry Authors: Xu Xu Tingting Xiao Changchang Zhang Zhiqiang Wang Gaoming Li Jingwen Chen Zhijun Ouyang Han Wang Xiangyang Shi Mingwu Shen Source Type: research

Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl < em > s < /em > -Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) < em > via < /em > EGFR/PI3K/AKT/mTOR Signaling Cascades
Pharmaceutics. 2022 Jul 27;14(8):1558. doi: 10.3390/pharmaceutics14081558.ABSTRACTHere, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid or neat acetic acid to afford a novel pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved to be efficient, with a shorter reaction time and high chemical y...
Source: Cancer Control - August 26, 2022 Category: Cancer & Oncology Authors: Ihab Shawish Assem Barakat Ali Aldalbahi Walhan Alshaer Fadwa Daoud Dana A Alqudah Mazhar Al Zoubi Ma'mon M Hatmal Mohamed S Nafie Matti Haukka Anamika Sharma Beatriz G de la Torre Fernando Albericio Ayman El-Faham Source Type: research

The Effect of Resveratrol on the Composition and State of Lipids and the Activity of Phospholipase A2 During the Excitation and Regeneration of Somatic Nerves
Conclusion It was established that both the nerve excitation conduction and the transection of somatic nerves lead to profound changes in the lipid composition. Not only the number of phospholipids, but also the phospholipid fatty acid composition is changing. The key factors responsible for the detected changes are phospholipase A2 and phospholipase C activities. In the first place of the nerve fiber degenerative processes were both Ca 2+-dependent and Ca 2+-independent phospholipase A2 activation in the fiber’s distal part, which associated with of the axonal transport blocking. Another factor affecting the nerv...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges
This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges o...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research