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Cancer: Pancreatic Cancer
Therapy: Immunotherapy
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Total 955 results found since Jan 2013.
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer
This study aimed to investigate whether the therapeutic benefits of tumor-targeting Claudin18.2 BiTE can be augmented by combining cancer selectively and immune-potentiating effects of OVs. Claudin18.2/CD3 BiTE was inserted into herpes simplex virus type 1 (HSV-1) to construct an OV-BiTE. Its expression and function were assessed using reporter cells and peripheral blood mononuclear cell (PBMC) co-culture assays. Intratumoral application of OV-BiTE restrained tumor growth and prolonged mouse survival compared with the unarmed OV in xenograft models and syngeneic mice bearing CLDN18.2-expressing KPC or Pan02 pancreatic canc...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Shiyu Liu Fan Li Li Deng Qiongqiong Ma Wenyi Lu Zhuoqian Zhao Huanzhen Liu Yixuan Zhou Manli Hu Hui Wang Yingbin Yan Mingfeng Zhao Hongkai Zhang Mingjuan Du Source Type: research
A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma
Aging (Albany NY). 2023 Sep 8;15. doi: 10.18632/aging.205008. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most common subtype, accounting for about 90% of all primary liver cancers. The liver is rich in a large number of immune cells, thus forming a special immune microenvironment, which plays a key role in the occurrence and development of hepatocellular carcinoma. Nowadays, tumor immunotherapy has become one of the most promising cancer treatment methods. Immune checkpoint inhibitors (ICIs) combined with VEGF inhibitors are listed as first-line treatment options for advanced HCC. Therefore, the se...
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Tianyu Wang Kang Xia Tao Qiu Shangting Han Zhongbao Chen Xiaoxiong Ma Long Zhang Jilin Zou Yalong Zhang Bo Yu Chenyang Kong Jiayu Guo Yiting Liu Jiangqiao Zhou Shusen Zheng Source Type: research
Cancers, Vol. 15, Pages 4450: Morphea, Eosinophilic Fasciitis and Cancer: A Scoping Review
This study is limited by the type of articles included (case reports, case series and observational studies), and hence, additional research on this important topic is needed.
Source: Cancers - September 7, 2023 Category: Cancer & Oncology Authors: Maxine Joly-Chevrier Alexa G élinas Stephanie Ghazal Sarah Moussa Catherine C. McCuaig Maryam Piram Alexandra Mereniuk Ivan V. Litvinov Mohammed Osman Kevin Pehr Elena Netchiporouk Tags: Review Source Type: research
An endoplasmic reticulum stress-related signature could robustly predict prognosis and closely associate with response to immunotherapy in pancreatic ductal adenocarcinoma
CONCLUSION: We established and validated an ERS-related prognostic signature comprising eight genes to predict the overall survival outcome of PDAC patients, which closely correlating with the response to immunotherapy and sensitivity to anti-tumor drugs, as well as could be beneficial for formulating clinical strategies and administering individualized treatments.PMID:37653101 | DOI:10.1007/s00432-023-05312-x
Source: Clinical Breast Cancer - August 31, 2023 Category: Cancer & Oncology Authors: Shuguang Liu Qianying Hu Zishan Xie Shaojing Chen Yixuan Li Nali Quan Kaimeng Huang Riqing Li Lishan Fang Source Type: research
Adipose-Tumor Crosstalk contributes to CXCL5 Mediated Immune Evasion in PDAC
CONCLUSIONS: In summary, our findings show that known adipokines TNF and IL-1β can stimulate CXCL5 release from PDAC cells in vitro. In vivo , CXCL5 depletion alone is sufficient to promote T cell infiltration into tumors in an obese setting, but requires checkpoint blockade inhibition to alleviate tumor burden.DATA AVAILABILITY STATEMENT: Raw and processed RNAseq data will be further described in the GEO accession database ( awaiting approval from GEO for PRJ number ). Additional raw data is included in the supplemental material and available upon reasonable request.WHAT IS ALREADY KNOWN ON THIS TOPIC: Obesity is linked ...
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: R McKinnon Walsh Joseph Ambrose Jarrid L Jack Austin E Eades Bailey Bye Mariana T Ruckert Appolinaire A Olou Fanuel Messaggio Prabhakar Chalise Dong Pei Michael N VanSaun Source Type: research
Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8 < sup > + < /sup > T cells
This study highlights the role of CD8+ T cells in the eradication of PDAC following KRAS∗ elimination and provides a rationale for the combination of KRAS∗ targeting with immunotherapy to control PDAC.PMID:37625403 | DOI:10.1016/j.devcel.2023.07.025
Source: Developmental Cell - August 25, 2023 Category: Cytology Authors: Krishnan K Mahadevan Valerie S LeBleu Elena V Ramirez Yang Chen Bingrui Li Amari M Sockwell Mihai Gagea Hikaru Sugimoto Lakshmi Kavitha Sthanam Desiree Tampe Michael Zeisberg Haoqiang Ying Abhinav K Jain Ronald A DePinho Anirban Maitra Kathleen M McAndrew Source Type: research
pH-Responsive Zinc Ion Regulating Immunomodulatory Nanoparticles for Effective Cancer Immunotherapy
Biomacromolecules. 2023 Aug 24. doi: 10.1021/acs.biomac.3c00557. Online ahead of print.ABSTRACTHerein, we introduce a novel approach involving the utilization of a human serum albumin-coated zeolite imidazolate framework-8 containing a photosensitizer (HPZ) that exhibits targeted recognition of the tumor microenvironment, enabling the rapid elevation of zinc ion concentrations while facilitating the controlled release of an encapsulated photosensitizer (PS). At a physiological pH of 7.4, HPZ demonstrates a size of approximately 170 nm, significantly decreasing to less than 10 nm under pH 6.5 acidic conditions. Acid-induced...
Source: Biomacromolecules - August 24, 2023 Category: Biochemistry Authors: Byoungjun Lim Kyoung Sub Kim Kun Na Source Type: research
