• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

mTOR inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines.
Conclusion: The present study has identified the TTF1-dependent molecular mechanisms through which inhibition of mTOR leads to redifferentiation of TC cells and subsequently to increased radioactive iodine uptake. PMID: 24712572 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - April 8, 2014 Category: Endocrinology Authors: Plantinga TS, Heinhuis B, Gerrits D, Netea MG, Joosten LA, Hermus AR, Oyen WJ, Schweppe RE, Haugen BR, Boerman OC, Smit JW, Netea-Maier RT Tags: J Clin Endocrinol Metab Source Type: research

Regulation of NADPH oxidase NOX4 by delta iodolactone (IL- δ) in thyroid cancer cells
Conclusions The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context. Graphical abstract
Source: Molecular and Cellular Endocrinology - May 27, 2018 Category: Endocrinology Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells
Cell Mol Life Sci. 2021 Jun 21. doi: 10.1007/s00018-021-03880-0. Online ahead of print.ABSTRACTStromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. The identity and function of these proteins in thyroid cancer remain elusive. We show that STIM1 and ORAI1 expression is elevated in thyroid cancer cell lines, compared to primary thyroid cells. Knock-down of STIM1 or ORAI1 attenuated SOCE, reduced invasion, and the expression of promigratory sphingosine 1-phosphate and vascular endothelial growth factor-2 receptors in th...
Source: Cellular and Molecular Life Sciences : CMLS - June 22, 2021 Category: Cytology Authors: Muhammad Yasir Asghar Taru Lassila Ilkka Paatero Van Dien Nguyen Pauliina Kronqvist Jixi Zhang Anna Slita Christoffer L öf You Zhou Jessica Rosenholm Kid T örnquist Source Type: research

Downregulation of Rap1GAP Expression Activates the TGF- < em > β < /em > /Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells
CONCLUSION: The downregulation of Rap1GAP expression can activate the TGF-β/Smad3 pathway to inhibit NIS expression and alter the tumor cell functions of PTC.PMID:34840979 | PMC:PMC8616680 | DOI:10.1155/2021/6840642
Source: Biomed Res - November 29, 2021 Category: Research Authors: Zheng Yan Wang Yangyanqiu Han Shuwen Mao Jing Liao Haihong Chen Gong Jin Yin Zhou Qing Gao Weili Source Type: research