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Cancer: Neuroblastoma
Nutrition: Antidoxidants
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Total 316 results found since Jan 2013.
Neuroprotection by Polyherbal Medicine Divya-Medha-Vati Against Scopolamine-Induced Cognitive Impairment Through Modulation of Oxidative Stress, Acetylcholine Activity, and Cell Signaling
In conclusion, the study showed that Divya-Medha-Vati was capable of promoting neuronal health and inhibiting Alzheimer-like cognitive dysfunction through enhanced antioxidant activities and modulation of neuronal activities.PMID:37707741 | DOI:10.1007/s12035-023-03601-7
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Acharya Balkrishna Kunal Bhattacharya Sunil Shukla Anurag Varshney Source Type: research
Transdermal delivery of mitochondrial-targeted hydrogen sulphide donor, AP39 protects against 6-hydroxydopamine-induced mitochondrial dysfunction
The objective of this study was to investigate the feasibility of transdermal delivery of mitochondrial-targeted H2S donor, AP39 whilst investigating the ability of permeated AP39 on abrogating 6-hydroxydopamine (6-OH-dop)-induced mitochondrial dysfunction, as a model of Parkinson's disease, established in human neuroblastoma cells, SHSY-5Y. Aqueous hypromellose gels (5% w/v) were prepared with up to 10% v/v propylene glycol (PG) with 0.002% w/w AP39. AP39 permeation from formulations across excised murine skin into PBS was quantified over 24 h using HPLC-UV detection. Media was collected and applied to a microvasculature ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 6, 2023 Category: Drugs & Pharmacology Authors: Mandeep Kaur Marwah Bahareh Manhoosh Hala Shokr Mohamad Anas Al Tahan Roderick Stewart Mohammed Iqbal Lorena Diaz Sanchez Sewa Abdullah Shakil Ahmad Keqing Wang Karan Singh Rana Lissette Sanchez-Aranguren Source Type: research
A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism
Mol Neurobiol. 2023 Sep 6. doi: 10.1007/s12035-023-03591-6. Online ahead of print.ABSTRACTCypermethrin impairs mitochondrial function, induces redox imbalance, and leads to Parkinsonism in experimental animals. Knockdown of deglycase-1 (DJ-1) gene, which encodes a redox-sensitive antioxidant protein, aggravates cypermethrin-mediated α-synuclein overexpression and oxidative alteration of proteins. DJ-1 is also reported to be essential for maintaining stability of nuclear factor erythroid 2-related factor 2 (Nrf2), shielding cells against oxidative insult. Leucine-rich repeat kinase 2 (LRRK2), another protein associated wit...
Source: Molecular Medicine - September 6, 2023 Category: Molecular Biology Authors: Alika Sarkar Mahendra Pratap Singh Source Type: research
Cell cycle and enzymatic activity alterations induced by ROS production in human neuroblastoma cells SH-SY5Y exposed to Fumonisin B1, Ochratoxin A and their combination
Toxicol In Vitro. 2023 Aug 24:105670. doi: 10.1016/j.tiv.2023.105670. Online ahead of print.ABSTRACTThe presence of mycotoxins such as Fumonisin B1(FB1) and Ochratoxin A (OTA) in food and feed has become a threat to human and animal health since they can produce several afflictions. Different mechanisms of action by which they exercise their cytotoxic activity have been attributed to them, including the production of reactive oxygen species (ROS). For this reason, a measurement of the production of ROS species, and an evaluation of the intrinsic cell enzymatic antioxidant activity, including glutathione peroxidase (GPx), g...
Source: Toxicology in Vitro - August 26, 2023 Category: Toxicology Authors: Raquel Penalva-Olcina Cristina Juan M ónica Fernández-Franzón Ana Juan-Garc ía Source Type: research
Antioxidant potentials of furanodihydrobenzoxanthones from Artocarpus elasticus and their protection against oxLDL induced injury in SH-SY5Y cells
Biomed Pharmacother. 2023 Aug 1;165:115278. doi: 10.1016/j.biopha.2023.115278. Online ahead of print.ABSTRACTExposure to reactive oxygen species (ROS) leads to the oxidation of low-density lipoproteins (LDL), converting them into oxidized ones (oxLDL), which are involved in the pathogenesis of Alzheimer's disease, suggesting a potential link between lipid dysregulation and neurodegenerative processes. Phenolic metabolites derived from Artocarpus elasticus root bark were found to possess significant antioxidant properties at three different radical scavenging assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), oxygen ra...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 3, 2023 Category: Drugs & Pharmacology Authors: Aizhamal Baiseitova Abdul Bari Shah Abdul Majid Khan Muhammad Idrees Jeong Ho Kim Yong Hyun Lee Il-Keun Kong Ki Hun Park Source Type: research
The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells
Arh Hig Rada Toksikol. 2023 Jun 26;74(2):106-114. doi: 10.2478/aiht-2023-74-3727. eCollection 2023 Jun 1.ABSTRACTKetamine is a dissociative anaesthetic used to induce general anaesthesia in humans and laboratory animals. Due to its hallucinogenic and dissociative effects, it is also used as a recreational drug. Anaesthetic agents can cause toxic effects at the cellular level and affect cell survival, induce DNA damage, and cause oxidant/antioxidant imbalance. The aim of this study was to explore these possible adverse effects of ketamine on hepatocellular HepG2 and neuroblastoma SH-SY5Y cells after 24-hour exposure to a co...
Source: Arhiv za Higijenu Rada i Toksikologiju - June 26, 2023 Category: Occupational Health Authors: Andreja Juri č Blanka Tariba Lovakovi ć Antonio Zandona Dubravka Ra šić Martin Češi Alica Pizent Marijana Neuberg Irena Canjuga Maja Katalini ć Ana Luci ć Vrdoljak Arnes Re šić Irena Br čić Karačonji Source Type: research
Combined exercise intervention in a mouse model of high-risk neuroblastoma: effects on physical, immune, tumor and clinical outcomes
CONCLUSIONS: Combined exercise appears as an effective strategy for attenuating physical function decline in a mouse model of HR-NB, also exerting some potential immune benefits within the tumor, which seem overall different from those previously reported in adult cancers.PMID:37358366
Source: Cancer Control - June 26, 2023 Category: Cancer & Oncology Authors: Cecilia Rinc ón-Castanedo Asunci ón Martín-Ruiz Sandra Zazo Ana L Luis Huertas Pedro L Valenzuela Mar ía Morán Steven J Fleck Alejandro Santos-Lozano Manuek Ram írez Federico Rojo Alejandro Lucia África González-Murillo Carmen Fiuza-Luces Source Type: research
The effects of ketamine on viability, primary DNA damage, and oxidative stress parameters in HepG2 and SH-SY5Y cells
Arh Hig Rada Toksikol. 2023 Jun 26;74(2):106-114. doi: 10.2478/aiht-2023-74-3727. eCollection 2023 Jun 1.ABSTRACTKetamine is a dissociative anaesthetic used to induce general anaesthesia in humans and laboratory animals. Due to its hallucinogenic and dissociative effects, it is also used as a recreational drug. Anaesthetic agents can cause toxic effects at the cellular level and affect cell survival, induce DNA damage, and cause oxidant/antioxidant imbalance. The aim of this study was to explore these possible adverse effects of ketamine on hepatocellular HepG2 and neuroblastoma SH-SY5Y cells after 24-hour exposure to a co...
Source: Arhiv za Higijenu Rada i Toksikologiju - June 26, 2023 Category: Occupational Health Authors: Andreja Juri č Blanka Tariba Lovakovi ć Antonio Zandona Dubravka Ra šić Martin Češi Alica Pizent Marijana Neuberg Irena Canjuga Maja Katalini ć Ana Luci ć Vrdoljak Arnes Re šić Irena Br čić Karačonji Source Type: research
