Filtered By:
Cancer: Neuroblastoma

This page shows you your search results in order of date. This is page number 14.

Order by Relevance | Date

Total 288 results found since Jan 2013.

Theranostics: Optical Imaging and Gene Therapy with Neuroblastoma‐Targeting Polymeric Nanoparticles for Potential Theranostic Applications (Small 9/2016)
Ligand‐modified, gene‐loaded nanoparticles (NPs) are designed and prepared as a tumor‐targeting theranostic agent by I. C. Kwon, K. Y. Lee, and co‐workers. The nanoparticles offer neuroblastoma‐specific in‐vivo optical imaging, and adding a therapeutic gene cocktail into the NPs could play a critical role for gene‐therapy‐based on RNAi. On page 1201, dye‐labeled NPs are modified with rabies virus glycoprotein peptide to enhance the receptor‐mediated uptake by neuroblastoma, and an siRNA cocktail is loaded into the NPs, inducing RNA interference and significantly suppressing tumor growth in a mouse model.
Source: Small - March 1, 2016 Category: Nanotechnology Authors: Jangwook Lee, Eun Ju Jeong, Yeon Kyung Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee Tags: Inside Front Cover Source Type: research

Ionizing radiation induces neuronal differentiation of Neuro-2a cells via PI3-kinase and p53-dependent pathways.
CONCLUSION: These results suggest that IR is able to trigger the neuronal differentiation of Neuro-2a cells and the activation of p53 via PI3K is an important step for the IR-induced differentiation of Neuro-2a cells. PMID: 25912236 [PubMed - indexed for MEDLINE]
Source: International Journal of Radiation Biology - February 18, 2016 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Transcriptome-wide targets of alternative splicing by RBM4 and possible role in cancer.
In conclusion, our findings reveal transcriptome-wide targets of RBM4 and point to potential cancer-related targets and mechanisms that may involve RBM4. PMID: 26898347 [PubMed - as supplied by publisher]
Source: Genomics - February 17, 2016 Category: Genetics & Stem Cells Authors: Markus MA, Yang YH, Morris BJ Tags: Genomics Source Type: research

The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression.
Authors: Tee AE, Liu B, Song R, Li J, Pasquier E, Cheung BB, Jiang C, Marshall GM, Haber M, Norris MD, Fletcher JI, Dinger ME, Liu T Abstract Neuroblastoma is the most common solid tumor during early childhood. One of the key features of neuroblastoma is extensive tumor-driven angiogenesis due to hypoxia. However, the mechanism through which neuroblastoma cells drive angiogenesis is poorly understood. Here we show that the long noncoding RNA MALAT1 was upregulated in human neuroblastoma cell lines under hypoxic conditions. Conditioned media from neuroblastoma cells transfected with small interfering RNAs (siRNA) ta...
Source: Oncotarget - February 9, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Abstract C25: Targeting cancer stem cells using ALDH-dependent 5-nitrofuran pro-drugs
We hypothesise that cancer stem cells with high aldehyde dehydrogenase (ALDHhigh) activity present a new therapeutic target and will be selectively sensitive to 5-nitrofuran pro-drugs.Cancers are heterogeneous and contain subpopulations of ALDHhigh cells with tumour initiating potential. ALDH enzymes metabolize toxic aldehydes, and are highly expressed in somatic and cancer stem cells (CSCs), although their function in stem cells is not fully understood. In a small molecule screen coupled with target ID, we recently discovered that clinically active 5-nitrofurans (5-NFNs) are substrates of ALDH2 (Zhou et al., 2012). 5-NFNs...
Source: Molecular Cancer Therapeutics - January 7, 2016 Category: Cancer & Oncology Authors: Crispin, R., Spockeli, N., Brunton, V., Carragher, N., Gourley, C., Houston, D., Unciti-Broceta, A., Patton, E. E. Tags: Cancer Stem Cells: Poster Presentations - Proffered Abstracts Source Type: research

Cholesterol‐rich lipid rafts are involved in neuropeptide FF anti‐nociceptin/orphanin FQ effect
Abstract The participation of a signaling platform to the anti‐nociceptin/orphanin FQ (N/OFQ) effect of neuropeptide FF (NPFF) receptors was investigated in both acutely dissociated neurons and SH‐SY5Y human neuroblastoma cells. The NPFF anti‐N/OFQ, not anti‐μ opioid effect, on the Ca2+ transient triggered by depolarization was reversed by methyl‐β‐cyclodextrin which depletes cholesterol from cell membranes. While the inactive α‐cyclodextrin had no effect. By using [35S]GTPγS binding assay, a significant 20% decrease in the activity of nociceptin/orphanin FQ peptide receptors induced by the NPFF analog 1D...
Source: Journal of Neurochemistry - December 27, 2015 Category: Neuroscience Authors: Zhong Ding, Jean‐Marie Zajac Tags: Original Article Source Type: research

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma.
Authors: Duffy DJ, Krstic A, Halasz M, Schwarzl T, Fey D, Iljin K, Mehta JP, Killick K, Whilde J, Turriziani B, Haapa-Paananen S, Fey V, Fischer M, Westermann F, Henrich KO, Bannert S, Higgins DG, Kolch W Abstract Despite intensive study, many mysteries remain about the MYCN oncogene's functions. Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. MYCN gene amplification occurs in 20% of cases, but other recurrent somatic mutations are rare. This scarcity of tractable targets has hampered efforts to develop new therapeutic options. We employed a multi-level omics approach t...
Source: Oncotarget - December 20, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Insulin-like growth factor 1 specifically up-regulates expression of modifier subunit of glutamate-cysteine ligase and enhances glutathione synthesis in SH-SY5Y cells.
Abstract Glutathione is a key regulator of oxidative balance in all mammals, especially in the central nervous system. The first step of glutathione synthesis is catalyzed by glutamate-cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM, respectively). In non-neural cells and tissues, insulin and insulin-like growth factor 1 (IGF-1) have been found to stimulate transcription of GCLC gene. Here we found that treatment of human neuroblastoma SH-SY5Y cells with insulin or IGF-1 increased mRNA level of GCLM, but not of GCLC, in a concentration- and time-dependent manner. In contr...
Source: European Journal of Pharmacology - December 11, 2015 Category: Drugs & Pharmacology Authors: Takahashi S, Hisatsune A, Kurauchi Y, Seki T, Katsuki H Tags: Eur J Pharmacol Source Type: research

Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid
In this study, the expression of a common neuronal differentiation marker [neurofilament M (NF-M)] in human SK-N-SH neuroblastoma cells treated with 10μM all-trans retinoic acid (ATRA) showed significantly increased expression in accordance with reduced cell number. This was accompanied by an increase in MitoSOX and DCFH2 oxidation that could be indicative of increased steady-state levels of reactive oxygen species (ROS) such as O2 •− and H2O2, which correlated with increased levels of MnSOD activity and immuno-reactive protein. Furthermore PEG-catalase inhibited the DCFH2 oxidation signal to a greater extent in the A...
Source: Redox Biology - December 8, 2015 Category: Biology Source Type: research

Cholesterol‐rich lipid rafts are involved in Neuropeptide FF anti‐Nociceptin/Orphanin FQ effect
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 30, 2015 Category: Neuroscience Authors: Zhong Ding, Jean‐Marie Zajac Tags: Original Article Source Type: research

Optical Imaging and Gene Therapy with Neuroblastoma‐Targeting Polymeric Nanoparticles for Potential Theranostic Applications
Recently, targeted delivery systems based on functionalized polymeric nanoparticles have attracted a great deal of attention in cancer diagnosis and therapy. Specifically, as neuroblastoma occurs in infancy and childhood, targeted delivery may be critical to reduce the side effects that can occur with conventional approaches, as well as to achieve precise diagnosis and efficient therapy. Thus, biocompatible poly(d,l‐lactide‐co‐glycolide) (PLG) nanoparticles containing an imaging probe and therapeutic gene are prepared, followed by modification with rabies virus glycoprotein (RVG) peptide for neuroblastoma‐targeting...
Source: Small - November 17, 2015 Category: Nanotechnology Authors: Jangwook Lee, Eun Ju Jeong, Yeon Kyung Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee Tags: Full Paper Source Type: research

GSE71061 Gene expression analysis of BE(2)C cells treated with MYCN siRNA (MYCN2 #SI03113670)
Contributor : Daniel CarterSeries Type : Expression profiling by arrayOrganism : Homo sapiensAmplification of the MYCN oncogene predicts treatment resistance in childhood neuroblastoma. Using a MYC target gene signature that predicts poor neuroblastoma prognosis we identified the histone chaperone, FAcilitates Chromatin Transcription (FACT), as a crucial mediator of the MYC signal and a therapeutic target in the disease. FACT and MYCN expression created a forward feedback loop in neuroblastoma cells that was essential for maintaining mutual high expression. FACT inhibition by the small molecule Curaxin compound, CBL0137, m...
Source: GEO: Gene Expression Omnibus - November 16, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE71060 Gene expression analysis of BE(2)C cells treated with MYCN siRNA (MYCN1 #SI03087518)
Contributor : Daniel CarterSeries Type : Expression profiling by arrayOrganism : Homo sapiensAmplification of the MYCN oncogene predicts treatment resistance in childhood neuroblastoma. Using a MYC target gene signature that predicts poor neuroblastoma prognosis we identified the histone chaperone, FAcilitates Chromatin Transcription (FACT), as a crucial mediator of the MYC signal and a therapeutic target in the disease. FACT and MYCN expression created a forward feedback loop in neuroblastoma cells that was essential for maintaining mutual high expression. FACT inhibition by the small molecule Curaxin compound, CBL0137, m...
Source: GEO: Gene Expression Omnibus - November 16, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE71059 Gene expression analysis of BE(2)C cells treated with SSRP1 siRNA
Contributor : Daniel CarterSeries Type : Expression profiling by arrayOrganism : Homo sapiensAmplification of the MYCN oncogene predicts treatment resistance in childhood neuroblastoma. Using a MYC target gene signature that predicts poor neuroblastoma prognosis we identified the histone chaperone, FAcilitates Chromatin Transcription (FACT), as a crucial mediator of the MYC signal and a therapeutic target in the disease. FACT and MYCN expression created a forward feedback loop in neuroblastoma cells that was essential for maintaining mutual high expression. FACT inhibition by the small molecule Curaxin compound, CBL0137, m...
Source: GEO: Gene Expression Omnibus - November 16, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Abstract PR09: MYCN and is a therapeutic target in neuroblastoma
Neuroblastoma is a childhood cancer of the sympathetic nervous system. Approximately 20% of patients present with an aggressive metastatic disease characterized by amplification of the MYCN locus. However, an additional 30% of patients suffer from an equally aggressive disease, yet there are no unified genetic markers available.To identify potential biomarkers of poor prognosis in neuroblastoma, we conducted unsupervised hierarchical clustering on 649 primary neuroblastoma tumors based on a 51 gene MYC core target signature. This demonstrated strong activation within the MYCN amplified cohort as expected, but surprisingly ...
Source: Molecular Cancer Research - October 18, 2015 Category: Cancer & Oncology Authors: Carter, D. R., Murray, J., Cheung, B. B., Kalla, H., Gamble, L., Tsang, J., Sutton, S., Koach, J., Syed, S., Gifford, A., Issaeva, N., Biktasova, A., Atmadibrata, B., Sun, Y., Sokolowski, N., Ling, D., Kim, P. Y., Webber, H., Clark, A., Ruhle, M., Liu, B. Tags: Targeting Myc-Driven Cancers: Oral Presentations - Proffered Abstracts Source Type: research