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Specialty: Urology & Nephrology
Cancer: Paraneoplastic Syndrome

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Total 1339 results found since Jan 2013.

Tumor induced osteomalacia: associated with elevated circulating levels of fibroblast growth factor-7 in addition to fibroblast growth factor-23.
Abstract Tumor induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, and osteomalacia. Fibroblast growth factor (FGF)-23, a phosphatonin i.e., phosphaturia-promoting hormone, is commonly implicated in the pathogenesis of TIO. However, very limited information is available about the circulating levels and clinical significance of other phosphatonins that are expressed by TIO-associated tumors. In addition, identification of the primary tumor constitutes a frequent major challenge in the management of TIO. Here, we report a patient with the clinical ...
Source: Clinical Nephrology - November 2, 2015 Category: Urology & Nephrology Authors: Bansal S, Khazim K, Suri R, Martin D, Werner S, Fanti P Tags: Clin Nephrol Source Type: research

Rare and changeable as a chameleon: paraneoplastic syndromes in renal cell carcinoma
ConclusionParaneoplastic syndromes are often unrecognized but are important biomarkers in RCC. Further research into the underlying pathomechanisms of PNS may improve our understanding of the RCC tumour biology and is urgently needed.
Source: World Journal of Urology - February 10, 2018 Category: Urology & Nephrology Source Type: research

Paraneoplastic cast nephropathy associated with malignant prolactinoma: A case report and literature review
We report on a 54-year-old man with a history of macroprolactinoma transforming into a pituitary carcinoma secreting both prolactin and growth hormone with metastases to the stomach, bone, lungs, retroperitoneum, and kidney. Reviewing the literature, this case is the first reporting of a pituitary carcinoma with biopsy-proven paraneoplastic cast nephropathy. Symptoms and renal function improved following a course of palliative chemotherapy and radiotherapy. After 2 years, his disease progressed requiring further palliative treatment that was complicated by severe chest sepsis. He was not fit for further chemotherapy, recei...
Source: Clinical Nephrology - May 10, 2022 Category: Urology & Nephrology Authors: Maha Mohamed Alison Brown Katrina Wood Edwin Wong Source Type: research

Incidence and clinical relevance of paraneoplastic syndromes in patients with renal cell carcinoma
CONCLUSIONS: Using EMR data, laboratory evidence of PNS was present in one-third of a contemporary cohort of patients undergoing nephrectomy, with >50% of PNS resolving after surgery. Consistent with prior reports, PNS are more common in higher-stage RCC and are associated with poorer survival in RCC patients.PMID:37537025 | DOI:10.1016/j.urolonc.2023.06.015
Source: Urologic Oncology - August 3, 2023 Category: Urology & Nephrology Authors: Tudor Moldovan Dennis Boynton Joshua Kuperus Jessica Parker Sabrina L Noyes Christopher M Brede Conrad M Tobert Brian R Lane Source Type: research

Leukemoid Reaction: A Rare Paraneoplastic Syndrome in Bladder Cancer Associated With a Grave Prognosis
A 43-year-old man presented with fevers to 101.8°F and malaise over a 2-week period. One month before presentation, he developed an episode of gross hematuria. Subsequent cystoscopy revealed a 5 cm bladder tumor. He underwent transurethral resection of the bladder tumor, and pathology showed muscle-invasive squamous cell carcinoma. His past medical history was significant for hemiplegia and frontal lobe syndrome secondary to a head injury, yet he did not have the typical risk factor of long-term indwelling catheter. He had no family history of genitourinary malignancy. He had a remote history of smoking as a teenager. He ...
Source: Urology - September 16, 2013 Category: Urology & Nephrology Authors: Daniel D. Shapiro, Aaron Potretzke, Tracy M. Downs Tags: Grand Rounds Source Type: research

Glomerular diseases and cancer: evaluation of underlying malignancy.
The objective of this review article is to: (i) discuss paraneoplastic glomerular disease, (ii) review cancer as an adverse effect of immunosuppressive agents used to treat glomerulopathies, and (iii) in the absence of international approved guidelines, propose a screening program based on expert opinion aimed at guiding nephrologists to early detect malignancies during their clinical practice. PMID: 26498294 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - October 26, 2015 Category: Urology & Nephrology Authors: Pani A, Porta C, Cosmai L, Melis P, Floris M, Piras D, Gallieni M, Rosner M, Ponticelli C Tags: J Nephrol Source Type: research

Small Renal Mass
In many ways, the focus of physicians treating kidney cancer has evolved greatly over the past two decades, not unlike that of those treating prostate cancer, from the management of advanced disease, to surgical refinement, to judicious consideration of who needs therapy. Historically, renal malignancies were deemed the “internist’s tumor” because they often presented with medical illnesses in the form of paraneoplastic symptoms, and they were often incurable by the time they were symptomatic. The classic triad of flank pain, hematuria, and a palpable bulge is now largely for historical interest only.
Source: Urologic Clinics of North America - April 13, 2017 Category: Urology & Nephrology Authors: Samir S. Taneja Tags: Foreword Source Type: research

Hypoglycemia in Renal Cell Carcinoma: A Rare Paraneoplastic Syndrome
A 65-year-old male adult foster care patient presented to the emergency room with altered mental status and respiratory depression which required intubation. The patient was also found to be hypoglycemic and hypertensive. He was admitted to the medical intensive care unit where a chronic type B aortic dissection and an exophytic superior pole right renal mass measuring 4.5  × 5.5 cm were discovered on CT scan (Figure 1). He continued experiencing recurrent episodes of hypoglycemia during his admission and was placed on double portion meals and intravenous glucose with dextrose 10% (D10) in water.
Source: Urology - October 9, 2018 Category: Urology & Nephrology Authors: Nicole DiIenno, Esther Han, Conrad Maitland, Velji Kansara Source Type: research

The Case | A paraneoplastic kidney injury?
An 80-year-old man was referred for acute kidney injury (AKI). His medical history included high blood pressure, obstructive sleep apnea, and benign prostatic hyperplasia.
Source: Kidney International - July 19, 2023 Category: Urology & Nephrology Authors: Lucile Duvaltier, Khalil El Karoui, Nelly Bosselut, Arnaud Boutan-Laroze, Jean-Jacques Boffa, David Buob, Romain Brousse Tags: Make Your Diagnosis Source Type: research