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Specialty: Cancer & Oncology
Cancer: Lung Cancer
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Total 651 results found since Jan 2013.
PARN Knockdown in Cell Lines Results in Differential and Cell-Specific Alterations in the Expression of Cancer-Associated mRNAs
CONCLUSION: The results of this study reveal that PARN deficiency leads to an altered stability of cancer-associated mRNA, distinctly, in cells of different lineages. Despite previous reports suggesting a potential therapeutic role of PARN in cancer, our results suggest that PARN may not be an important biomarker, particularly in lung cancer.PMID:35092390 | DOI:10.31557/APJCP.2022.23.1.207
Source: Asian Pacific Journal of Cancer Prevention - January 29, 2022 Category: Cancer & Oncology Authors: Nishith Babu Dechamma Pandyanda Nanjappa Sandra Nazareth Srividya Arjuna Anirban Chakraborty Source Type: research
SOX2 knockdown with siRNA reverses cisplatin resistance in NSCLC by regulating APE1 signaling
AbstractSOX2 is related to drug resistance in many types of cancer, including lung cancer. Herein, we investigated the role of SOX2 and its regulatory signaling in cisplatin-treated non-small-cell lung cancer (NSCLC). The effects of SOX2 on cell viability, proliferation, and apoptosis were evaluated in vitro. Western blotting, real-time quantitative PCR, immunohistochemistry, and luciferase reporter assays were used to investigate the underlying mechanism. Kaplan –Meier survival analysis and the log-rank test were used to assess the relationship between SOX2 expression and patient survival. A549/CDDP cells had marked res...
Source: Medical Oncology - January 20, 2022 Category: Cancer & Oncology Source Type: research
CircRNA ANXA2 Promotes Lung Cancer Proliferation and Metastasis by Upregulating PDPK1 Expression
This study focused on the role of circRNA ANXA2 (circANXA2) in lung cancer and the molecular mechanism of cancer promotion. Real-time quantitative PCR (RT-PCR) was used in detecting the expression abundance of circANXA2 in different lung cancer cells and tissues. The subcellular localization of circANXA2 was detected through fluorescence in situ hybridization. circANXA2 expression was knocked down through siRNA. CCK-8, clone formation assay, and TUNEL assay were used in evaluating the effects of circANXA2 on cell proliferation, clone formation ability, and apoptosis. The role of circANXA2 in tumor proliferation was further...
Source: Journal of Oncology - January 7, 2022 Category: Cancer & Oncology Authors: Yan Ju Bin Yuan Wenan Wu Jin Zhao Xiaorui Shi Source Type: research
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type-2 inflammation
J Clin Invest. 2021 Nov 11:e151685. doi: 10.1172/JCI151685. Online ahead of print.ABSTRACTAltered redox biology challenges all cells, with compensatory responses often determining a cell's fate. When 15 lipoxygenase-1 (15LO1), a lipid peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine binding protein-1 (PEBP1), hydroperoxy-phospholipids, which drive ferroptotic cell death, are generated. Peroxidases, including glutathione peroxidase-4 (GPX4), metabolize hydroperoxy-phospholipids to hydroxy derivatives to prevent ferroptotic death, but consume reduced glutathione ...
Source: Clinical Lung Cancer - November 11, 2021 Category: Cancer & Oncology Authors: Tadao Nagasaki Alexander J Schuyler Jinming Zhao Svetlana N Samovich Kazuhiro Yamada Yanhan Deng Scott P Ginebaugh Stephanie A Christenson Prescott G Woodruff John V Fahy John B Trudeau Detcho Stoyanovsky Anuradha Ray Yulia Y Tyurina Valerian E Kagan Sall Source Type: research
MicroRNA-3907 promotes the proliferation and migration of sebaceous gland carcinoma of the eyelid by targeting thrombospondin 1
Oncol Lett. 2021 Dec;22(6):833. doi: 10.3892/ol.2021.13094. Epub 2021 Oct 14.ABSTRACTMicroRNAs (miRNAs/miRs) play an important role in various types of carcinoma, including sebaceous gland carcinoma (SGC) of the eyelid. miR-3907 was found to be highly expressed in lung cancer; however, to the best of our knowledge, the biological role of miR-3907 in SGC has not previously been evaluated. The aim of the present study was to determine the role and mechanism of miR-3907 in the occurrence and development of SGC. miR-3907 was screened and identified as a novel upregulated miRNA in SGC tissues and cells, as determined using miRN...
Source: Oncology Letters - October 25, 2021 Category: Cancer & Oncology Authors: Chuanli Zhang Limin Zhu Xun Liu Meixia Jiang Qin Tang Fei Xu Tingting Lin Lijie Dong Yanjin He Source Type: research
SPTBN2, a New Biomarker of Lung Adenocarcinoma
ConclusionWe uncovered a novel gene, SPTBN2, that was significantly upregulated in LUAD tissues relative to normal tissue expression. SPTBN2 is highly expressed in LUAD, positively correlated with poor prognosis, and can promote the proliferation, migration, and invasion of LUAD cells.
Source: Frontiers in Oncology - October 20, 2021 Category: Cancer & Oncology Source Type: research
Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion
CONCLUSION: These findings indicated that CAP1 phosphorylation can promote lung cancer proliferation, migration, and invasion. Phosphorylation sites of CAP1 might be a novel target for lung cancer treatment.PMID:34636991 | DOI:10.1007/s00432-021-03819-9
Source: Clinical Lung Cancer - October 12, 2021 Category: Cancer & Oncology Authors: Jie Zeng Xuan Li Long Liang Hongxia Duan Shuanshuan Xie Changhui Wang Source Type: research
Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells
CONCLUSIONS: Our study found that ADD3 functioned as a tumor suppressor gene during osteosarcoma development. The abnormal upregulation of miR-23b-3p targeted the expression of ADD3 and resulted in accelerated osteosarcoma cell proliferation and migration. Thus, the miR-23b-3p/ADD3 axis contributes to the development of osteosarcoma and ADD3 is a key driver of malignancy.PMID:34632867 | DOI:10.1177/03008916211050687
Source: Tumori - October 11, 2021 Category: Cancer & Oncology Authors: Zhigang Suo Xiucai Ma Yueping Ding Yu Zhou Xiangguo Duan Le Fei Jianmin Song Huiqiang Ding Source Type: research
