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Total 241 results found since Jan 2013.

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies
Abstract Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of a...
Source: Clinical Reviews in Allergy and Immunology - June 7, 2016 Category: Allergy & Immunology Source Type: research

Nebulized Fentanyl for Dyspnea in a Hospice Patient with True Allergy to Morphine and Hydromorphone.
Authors: Wahler RG, Smith DB, Mulcahy KB Abstract An 86-year-old white female was admitted to hospice care with lung cancer. Even with optimal medical management, she suffered from dyspnea and required opioid therapy. However, the patient had a true morphine and hydromorphone allergy. She was administered nebulized fentanyl for symptomatic relief of dyspnea with good effect and she did not experience any allergic response. PMID: 28287363 [PubMed - in process]
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 15, 2017 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Allergen immunotherapy, cancer, and immune disorders
Purpose of review The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years. Recent findings Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic f...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Marijuana: Respiratory Tract Effects.
Abstract Marijuana is the most commonly used drug of abuse in the USA. It is commonly abused through inhalation and therefore has effects on the lung that are similar to tobacco smoke, including increased cough, sputum production, hyperinflation, and upper lobe emphysematous changes. However, at this time, it does not appear that marijuana smoke contributes to the development of chronic obstructive pulmonary disease. Marijuana can have multiple physiologic effects such as tachycardia, peripheral vasodilatation, behavioral and emotional changes, and possible prolonged cognitive impairment. The carcinogenic effects ...
Source: Clinical Lung Cancer - May 29, 2013 Category: Cancer & Oncology Authors: Owen KP, Sutter ME, Albertson TE Tags: Clin Rev Allergy Immunol Source Type: research

Epigenetics in Immune-Mediated Pulmonary Diseases.
Abstract Immune-mediated pulmonary diseases are a group of diseases that resulted from immune imbalance initiated by allergens or of unknown causes. Inflammatory responses without restrictions cause tissue damage and remodeling, which leads to airway hyperactivity, destruction of alveolar architecture, and a resultant loss of lung function. Epigenetic mechanisms have been demonstrated to be involved in inflammation, autoimmunity, and cancer. Recent studies have identified that epigenetic changes also regulate molecular pathways in immune-mediated lung diseases. Aberrant DNA methylation status, dysregulation of his...
Source: Clinical Lung Cancer - November 19, 2013 Category: Cancer & Oncology Authors: Liu Y, Li H, Xiao T, Lu Q Tags: Clin Rev Allergy Immunol Source Type: research

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.
CONCLUSION: These data highlight a critical role for ILC2s in the development of adaptive type 2 responses to local, but not systemic, antigen exposure. PMID: 24679471 [PubMed - in process]
Source: Clinical Lung Cancer - April 1, 2014 Category: Cancer & Oncology Authors: Gold MJ, Antignano F, Halim TY, Hirota JA, Blanchet MR, Zaph C, Takei F, McNagny KM Tags: J Allergy Clin Immunol Source Type: research

Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis.
CONCLUSION: This is the first report that exploits next-generation sequencing to determine local and peripheral blood IGH repertoires in patients with respiratory allergic disease. We demonstrate that natural pollen exposure was associated with changes in IgE repertoires that were suggestive of ongoing germinal center reactions. Furthermore, these changes were more often apparent in nasal biopsy specimens compared with peripheral blood and in patients with AR compared with healthy control subjects. PMID: 25171866 [PubMed - in process]
Source: Clinical Lung Cancer - September 1, 2014 Category: Cancer & Oncology Authors: Wu YC, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ Tags: J Allergy Clin Immunol Source Type: research

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies.
Abstract Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients' survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF-A, IgE, an...
Source: Clinical Colorectal Cancer - June 7, 2016 Category: Cancer & Oncology Authors: Bonamichi-Santos R, Castells M Tags: Clin Rev Allergy Immunol Source Type: research

miRNAs are required for Langerhans cell, skin and lung resident macrophage ontogeny.
Abstract CAPSULE SUMMARY: Our study demonstrates that miRNAs serve as critical epigenetic regulators in the ontogeny of LCs and TRMs in the skin and lungs, suggesting that miRNAs may be promising targets for LC and TRM-related allergic diseases. PMID: 29751006 [PubMed - as supplied by publisher]
Source: Clinical Lung Cancer - May 8, 2018 Category: Cancer & Oncology Authors: Yao Y, Martin C, Yin C, Guo C, Dong Z, Zhou L, Mi QS Tags: J Allergy Clin Immunol Source Type: research

Involvement of miR-126 in autoimmune disorders.
Conclusion: Although miR-126 relevant role in several immune-related diseases, further studies are needed to clear its molecular mechanisms; the final step of these novel researches could be the blockage or the prevention of the diseases onset by creating of new targeted therapy. PMID: 29743819 [PubMed]
Source: Clinical Lung Cancer - May 12, 2018 Category: Cancer & Oncology Authors: Casciaro M, Di Salvo E, Brizzi T, Rodolico C, Gangemi S Tags: Clin Mol Allergy Source Type: research

High ambient levels of grass, weed and other pollens are associated with asthma admissions in children and adolescents: A large 5-year case-crossover study.
CONCLUSIONS: Although boys are more vulnerable to grass pollen, weed, and other pollens are also important triggers of asthma exacerbations in all children and adolescents. These findings are important for urban green space planning and the development of pollen monitoring systems for families with children at risk of asthma exacerbations during peak pollen seasons. This article is protected by copyright. All rights reserved. PMID: 29975808 [PubMed - as supplied by publisher]
Source: Clinical Lung Cancer - July 5, 2018 Category: Cancer & Oncology Authors: Shrestha SK, Katelaris C, Dharmage SC, Burton P, Vicendese D, Tham R, Abramson MJ, Erbas B Tags: Clin Exp Allergy Source Type: research

Long term outcome of WHIM syndrome in 18 patients: high risk of lung disease and HPV-related malignancies.
CONCLUSION: The WHIM syndrome onsets early in life and should be suspected in patients with chronic neutropenia. WHIM patients need careful monitoring and timely intervention for complications, mainly lung disease and HPV-related malignancies. We suggest that immunoglobulin replacement therapy should be promptly considered to control the frequency of bacterial infections and prevent chronic lung damage. PMID: 30716504 [PubMed - as supplied by publisher]
Source: Clinical Lung Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Dotta L, Notarangelo LD, Moratto D, Kumar R, Porta F, Soresina A, Lougaris V, Plebani A, Smith CIE, Norlin AC, Gòmez Raccio AC, Bubanska E, Bertolini P, Amendola G, Visentini M, Fiorilli M, Venuti A, Badolato R Tags: J Allergy Clin Immunol Pract Source Type: research

Detection of Novel Autoantibodies to Nucleolin's RNA-binding Domains as a Serum Tumor Biomarker Through ELISA
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):616-625. doi: 10.18502/ijaai.v21i6.11520.ABSTRACTExpression and location of nucleolin are often abnormal in malignancies, which may result in the production of autoantibodies. Despite this, the identification of such autoantibodies may be essential for the early diagnosis and prognosis of cancers. In this investigation, the recombinant nucleolin protein was generated using an Escherichia coli expression system and was used an indirect enzyme-linked immunosorbent assay to detect anti-nucleolin autoantibodies in cancer patients' sera. Lung cancer patients' autoantibodies displ...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Fatemeh Ezzatifar Alireza Rafiei Reza Valadan Hossein Asgarian-Omran Mahmood Jeddi-Tehrani Source Type: research