Long term outcome of WHIM syndrome in 18 patients: high risk of lung disease and HPV-related malignancies.

CONCLUSION: The WHIM syndrome onsets early in life and should be suspected in patients with chronic neutropenia. WHIM patients need careful monitoring and timely intervention for complications, mainly lung disease and HPV-related malignancies. We suggest that immunoglobulin replacement therapy should be promptly considered to control the frequency of bacterial infections and prevent chronic lung damage.
PMID: 30716504 [PubMed - as supplied by publisher]

Source: Clinical Lung Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Dotta L, Notarangelo LD, Moratto D, Kumar R, Porta F, Soresina A, Lougaris V, Plebani A, Smith CIE, Norlin AC, Gòmez Raccio AC, Bubanska E, Bertolini P, Amendola G, Visentini M, Fiorilli M, Venuti A, Badolato R Tags: J Allergy Clin Immunol Pract Source Type: research