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In Situ Formed ROS-responsive Hydrogel with STING Agonist and Gemcitabine to Intensify immunotherapy Against Pancreatic Ductal Adenocarcinoma
This article is protected by copyright. All rights reserved.PMID:36971070 | DOI:10.1002/adhm.202203264
Source: Adv Data - March 27, 2023 Category: Epidemiology Authors: Meng Wang Qida Hu Junming Huang Fu Zhang Zhuo Yao Shiyi Shao Xinyu Zhao Tingbo Liang Source Type: research

Characterization of procyanidin extracts from hawthorn (Crataegus pinnatifida) in human colorectal adenocarcinoma cell line Caco-2, simulated Digestion, and fermentation identified unique and novel prebiotic properties
This study aims to explore the dynamic changes of HPCs during in vitro digestion and fermentation, as well as their Caco-2 permeability, focusing mainly on the interaction between gut microbiota and HPCs. The results showed that the digested HPC samples had characteristic absorption peaks at 280 nm, and there were absorption peaks in the stretching vibration zone, including OH and CC on the benzene ring, which suggested that procyanidins were the main components in HPCs after in vitro digestion. Meanwhile, HPCs had the highest stability in the oral phase. However, the total procyanidin content of HPCs decreased during gast...
Source: Cell Research - March 4, 2023 Category: Cytology Authors: Xue Han Qian Zhou Zhe Gao Guanying Bianca Xu Hong Chen Bimal Chitrakar Yasai Sun Wen Zhao Xuan Lin Kaixuan Zhou Zhisheng Zhang Source Type: research

Synthesis and Anticancer activity of Novel Chromene Derivatives, Chromeno2,3-d1,3oxazines, and Chromeno2,3-dpyrimidines
CONCLUSION: Several chromene derivatives had been synthesized and their structures had been confirmed using different spectroscopic techniques. Some of the chromene derivatives that were screened against different cancer cell lines showed promising anticancer activity higher than the reference standard drug. For example, chromene derivative 2 had anticancer activity against human colon cancer cell lines (HT-29) higher than the reference drug doxorubicin. Chromene derivative 5 had anticancer activity against liver cancer cell lines (HepG-2) higher than the reference drug doxorubicin. Chromene derivative 6 had anticancer act...
Source: Medicinal Chemistry - December 27, 2022 Category: Chemistry Authors: Mahmoud N M Yousif Usama Fathy Nabil M Yousif Source Type: research

Dimethyl cardamonin from fruits of Campomanesia reitziana D. Legrand promotes gastroprotection and gastric healing effects in rodents
Chem Biodivers. 2022 Oct 17. doi: 10.1002/cbdv.202200727. Online ahead of print.ABSTRACTCampomanesia reitziana D. Legrand (Myrtaceae) displays antiulcer properties when given to rodents. The major active chemical components of C. reitziana are chalcones, including 4',6'-dihydroxy-3',5'-dimethyl-2'-methoxy chalcone or dimethyl cardamonin (DMC), therefore, we hypothesized that this compound could have antiulcer effects and the aim of the present study was to evaluate its gastroprotective and gastric healing properties. DMC was isolated from the fruits of C. reitziana and its gastroprotective effect was evaluated by ethanol a...
Source: Chemistry and Biodiversity - October 17, 2022 Category: Biochemistry Authors: Benhur Judah Cury Thaise Boeing Lincon Bordignon Somensi Adriana Campos Valdir Cechinel-Filho Priscila de Souza Luisa Mota da Silva Source Type: research

Potential of unglycosylated horseradish peroxidase variants for enzyme prodrug cancer therapy
In this study, we generated recombinant, unglycosylated HRP variants in Escherichia coli using random mutagenesis and investigated their biochemical properties and suitability for cancer treatment. The cytotoxicity of the HRP-IAA enzyme prodrug system was assessed in vitro with HCT-116 human colon, FaDu human nasopharyngeal squamous cell carcinoma and murine colon adenocarcinoma cells (MC38). Extensive cytotoxicity was shown in all three cancer cell lines: the cell viability of HCT-116 and MC38 cells treated with HRP-IAA was below 1% after 24 h incubation and the surviving fraction of FaDu cells was ≤ 10% after 72 h. How...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 15, 2021 Category: Drugs & Pharmacology Authors: Diana Humer Valentina Furlanetto Anna-Katharina Schruef Angelika Wlodarczyk Mario Kuttke Christina Divne Oliver Spadiut Source Type: research

Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges
This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges o...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research