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Specialty: Molecular Biology
Cancer: Adenocarcinoma

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Total 75 results found since Jan 2013.

The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma
Mol Cell Biol. 2022 Jun 15:e0001822. doi: 10.1128/mcb.00018-22. Online ahead of print.ABSTRACTYes-associated protein 1 (YAP1) is indispensable for the development of mutant KRAS-driven pancreatic ductal adenocarcinoma (PDAC). High YAP1 mRNA is a prognostic marker for worse overall survival in patient samples; however, the regulatory mechanisms that mediate its overexpression are not well understood. YAP1 genetic alterations are rare in PDAC, suggesting that its dysregulation is likely not due to genetic events. HuR is an RNA-binding protein whose inhibition impacts many cancer-associated pathways, including the "conserved ...
Source: Mol Biol Cell - June 15, 2022 Category: Molecular Biology Authors: Samantha Z Brown Grace A McCarthy James R Carroll Roberto Di Niro Carl Pelz Aditi Jain Thomas L Sutton Hannah D Holly Avinoam Nevler Christopher W Schultz Matthew D McCoy Joseph A Cozzitorto Wei Jiang Charles J Yeo Dan A Dixon Rosalie C Sears Jonathan R B Source Type: research

LncRNA PWAR6 regulates proliferation and migration by epigenetically silencing YAP1 in tumorigenesis of pancreatic ductal adenocarcinoma
In conclusion, our data manifest the vital roles of PWAR6 in PDAC tumorigenesis and underscore the potential of PWAR6 as a promising target for PDAC diagnosis and therapy.PMID:33834618 | DOI:10.1111/jcmm.16480
Source: Molecular Medicine - April 9, 2021 Category: Molecular Biology Authors: Shanshan Huang Yaqi Li Jinhua Hu Li Li Zhen Liu Hui Guo Bailing Jiang Jun Chen Junhe Li Xiaojun Xiang Jun Deng Jianping Xiong Source Type: research

Role of DACH1 on proliferation, invasion, and apoptosis in human lung adenocarcinoma cells.
CONCLUSION: DACH1 is downregulated in lung adenocarcinoma tissue. In vitro assessment shows that DACH1 functions as a tumor suppressor, suggesting its potential use as new target for lung cancer treatment. PMID: 33463463 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - January 18, 2021 Category: Molecular Biology Authors: Yu J, Jiang P, Zhao K, Chen Z, Zuo T, Chen B Tags: Curr Mol Med Source Type: research

Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer
Conclusion: This approach provides a new therapeutic avenue to improve the antitumor efficacy of PDAC therapies by normalizing tumor stroma using the PCBP2 siRNA nanocomplex.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F. Staveley-OCarroll, Guangfu Li, Kun Cheng Tags: Research Paper Source Type: research

USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer
Conclusions: Taken together, these results provide evidence to suggest that therapeutic approaches targeting USP7, in combination with immunotherapy, should be considered for lung cancer treatment.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Xiaomeng Dai, Lisen Lu, Suke Deng, Jingshu Meng, Chao Wan, Jing Huang, Yajie Sun, Yan Hu, Bian Wu, Gang Wu, Jonathan F. Lovell, Honglin Jin, Kunyu Yang Tags: Research Paper Source Type: research

Ribosomal protein S3 selectively affects colon cancer growth by modulating the levels of p53 and lactate dehydrogenase.
In this study, we aim at determining the expression levels of RPS3 in a colon cancer cell line Caco-2 compared to a normal colon mucosa cell line NCM-460 and study the effects of targeting this protein by siRNA on cellular behavior. RPS3 was found to be expressed in both cell lines. However, siRNA treatment showed a more protruding effect on Caco-2 cells compared to NCM-460 cells. RPS3 knockdown led to a significant decrease in the proliferation, survival, migration and invasion and an increase in the apoptosis of Caco-2 cells. Western blot analysis demonstrated that these effects correlated with an increase in the level o...
Source: Molecular Biology Reports - August 2, 2020 Category: Molecular Biology Authors: Alam E, Maaliki L, Nasr Z Tags: Mol Biol Rep Source Type: research

Long non-coding RNA H19 is responsible for the progression of lung adenocarcinoma by mediating methylation-dependent repression of CDH1 promoter.
Abstract Lung adenocarcinoma is a common histologic type of lung cancer with a high death rate globally. Increasing evidence shows that long non-coding RNA H19 (lncRNA H19) and CDH1 methylation are involved in multiple tumours. Here, we tried to investigate whether lncRNA H19 or CDH1 methylation could affect the development of lung adenocarcinoma. First, lung adenocarcinoma tissues were collected to detect CDH1 methylation. Then, the regulatory mechanisms of lncRNA H19 were detected mainly in concert with the treatment of overexpression of lncRNA H19, siRNA against lncRNA H19, overexpression of CDH1 and demethylat...
Source: J Cell Mol Med - July 16, 2019 Category: Molecular Biology Authors: Gao LM, Xu SF, Zheng Y, Wang P, Zhang L, Shi SS, Wu T, Li Y, Zhao J, Tian Q, Yin XB, Zheng L Tags: J Cell Mol Med Source Type: research

Chemotherapy priming of the Pancreatic Tumor Microenvironment Promotes Delivery and Anti-Metastasis Efficacy of Intravenous Low-Molecular-Weight Heparin-Coated Lipid-siRNA Complex
Conclusion: These results suggested our sequential delivery of PTX-Lip and LH-Lip/siBCL-2 might provide a practical approach for PDAC or other ECM-rich tumors.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Qianwen Yu, Yue Qiu, Xiaoxiao Chen, Xuhui Wang, Ling Mei, Haiyao Wu, Kai Liu, Yayuan Liu, Man Li, Zhirong Zhang, Qin He Tags: Research Paper Source Type: research

BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1
Conclusion: Our data indicated that BPI-9016M is an effective agent against lung adenocarcinoma, particularly in tumors with c-Met activation, and likely functions through upregulation of miR203 leading to reduced DKK1 expression.
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Panpan Zhang, Shaolei Li, Chao Lv, Jiahui Si, Ying Xiong, Lieming Ding, Yuanyuan Ma, Yue Yang Tags: Research Paper Source Type: research

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
Publication date: Available online 5 October 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Giovanna Butera, Raffaella Pacchiana, Nidula Mullappilly, Marilena Margiotta, Stefano Bruno, Paola Conti, Chiara Riganti, Massimo DonadelliAbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated generally resulting in conformational changes of mutant p53 (mutp53) proteins, which acquire oncogenic functions triggering aggressiveness of cancers and alteration of energetic metabo...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 6, 2018 Category: Molecular Biology Source Type: research

NEK4 kinase regulates EMT to promote lung cancer metastasis.
Abstract Epithelial-to-mesenchymal transition (EMT) is a dynamic transitional state from the epithelial to mesenchymal phenotypes. Numerous studies have suggested that EMT and its intermediate states play important roles in tumor invasion and metastasis. To identify novel regulatory molecules of EMT, we screened a siRNA library targeting human 720 kinases in A549 lung adenocarcinoma cells harboring E-cadherin promoter-luciferase reporter vectors. NIMA-related kinase-4 (NEK4) was identified and characterized as a positive regulator of EMT in the screening. Suppression of NEK4 resulted in the inhibition of cell migr...
Source: J Cell Mol Med - September 24, 2018 Category: Molecular Biology Authors: Ding NH, Zhang L, Xiao Z, Rong ZX, Li Z, He J, Chen L, Ou DM, Liao WH, Sun LQ Tags: J Cell Mol Med Source Type: research

ZIP9 but not the androgen receptor mediates testosterone-induced migratory activity of metastatic prostate cancer cells
Publication date: Available online 15 September 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Ahmed Bulldan, Joerg-Walter Bartsch, Lutz Konrad, Georgios Scheiner-BobisAbstractLNCaP cells are derived from a metastatic lesion of human prostate adenocarcinoma. They express the classical androgen receptor (AR) and ZIP9, a Zn2+ transporter that also binds testosterone and mediates signaling by interacting with G-proteins.Our results show that LNCaP cells respond to testosterone by mobilizing their migratory machinery. Their exposure to testosterone triggers the formation of lamellipodia, re...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 16, 2018 Category: Molecular Biology Source Type: research