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Cancer: Adenocarcinoma

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Total 766 results found since Jan 2013.

Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
In conclusion, there is a crosstalk between polyamines and MAT2A. Increased MAT2A expression provides more SAMe for polyamines biosynthesis; increased polyamine (putrescine in this case) can activate MAT2A at the transcriptional level. This along with increased ODC expression in cancer all feed forward to further enhance the proliferative capacity of the cancer cell. PMID: 23588207 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - April 12, 2013 Category: Cytology Authors: Tomasi ML, Ryoo M, Skay A, Tomasi I, Giordano P, Mato JM, Lu SC Tags: Exp Cell Res Source Type: research

HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis
Conclusion: the present study confirms the overexpression of HOXB7 mRNA expression in PDAC and demonstrates that decreasing its protein level by siRNA could significantly increase apoptosis and modulate several biological processes. HOXB7 might be a promising target for future therapies.
Source: BMC Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Thais ChileMaria FortesMaria Corrêa-GiannellaHelena BrentaniDurvanei AugustoRenato PugaVanessa de PaulaMarcia KubruslyEstela NovakTelésforo BacchellaRicardo Giorgi Source Type: research

B7-H4 downregulation induces mitochondrial dysfunction and enhances doxorubicin sensitivity via the cAMP/CREB/PGC1-α signaling pathway in HeLa cells.
Abstract B7-H4 is a B7 family coregulatory protein that inhibits T cell-mediated immunity. B7-H4 is overexpressed in various cancers; however, the functional role of B7-H4 in cancer metabolism is poorly understood. Because mitochondria play pivotal roles in development, proliferation, and death of cancer cells, we investigated molecular and functional alterations of mitochondria in B7-H4-depleted HeLa cells. In a human study, overexpression of B7-H4 was confirmed in the cervices of adenocarcinoma patients (n = 3) compared to noncancer patients (n = 3). In the cell line model, B7-H4 depletion was performed ...
Source: Pflugers Archiv : European Journal of Physiology - March 23, 2014 Category: Physiology Authors: Kim HK, Song IS, Lee SY, Jeong SH, Lee SR, Heo HJ, Thu VT, Kim N, Ko KS, Rhee BD, Jeong DH, Kim YN, Han J Tags: Pflugers Arch Source Type: research

Role Of Intracellular Calcium And NADPH Oxidase NOX5-S In Acid-Induced DNA Damage In Barrett's cells and Barrett's Esophageal Adenocarcinoma Cells.
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca(2+) in FLO cells, an increase which is blocked by Ca(2+) free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of i...
Source: Am J Physiol Gastroi... - April 3, 2014 Category: Gastroenterology Authors: Li D, Cao W Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma.
This study aims to find the key LncRNA associated with lung adenocarcinoma and to evaluate its biological role and clinical significance in tumor progression. Microarray analysis of 32,756 LncRNA was performed to screen the significantly different LncRNA between human lung adenocarcinoma tissues and adjacent non-cancerous lung tissues, which was named as LncRNA ZXF1. Expression of LncRNA ZXF1 was analyzed in 62 lung adenocarcinoma tissues and adjacent non-cancerous lung tissues by quantitative reverse-transcription PCR (qRT-PCR). Correlations between LncRNA ZXF1 expression and the clinicopathological features and prognosis...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2014 Category: Drugs & Pharmacology Authors: Zhang L, Zhou XF, Pan GF, Zhao JP Tags: Biomed Pharmacother Source Type: research

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy.
CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. PMID: 24764668 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 21, 2014 Category: Gastroenterology Authors: Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, Nomura F Tags: World J Gastroenterol Source Type: research

Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca2+ in FLO cells, an increase that is blocked by Ca2+-free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of intrac...
Source: AJP: Gastrointestinal and Liver Physiology - May 15, 2014 Category: Gastroenterology Authors: Li, D., Cao, W. Tags: CANCER BIOLOGY Source Type: research

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling
Conclusion: Our results demonstrate that the impact of S6K1 kinase on neuroblastoma cells is not mediated through modulation of GLI1 expression/activity.
Source: BMC Cancer - August 18, 2014 Category: Cancer & Oncology Authors: Yumei DiaoMohammed RahmanVictoria VillegasMalin WickströmJohn JohnsenPeter Zaphiropoulos Source Type: research

908P * NUCLEAR EXPRESSION OF BCL10 HAS A ROLE IN THE REGULATION OF CELL GROWTH OF OVARIAN CANCER THROUGH THE ACTIVATION OF NF-{kappa}B-DEPENDENT CYCLIN D1 SIGNALING
Conclusions: Our findings indicate that nuclear BCL10 plays an important role in controlling the growth and progression of ovarian cancer cells through NF-B dependent cyclin D1 regulation.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Kuo, S., Chou, C., Chen, R., Cheng, A. Tags: gynaecological cancers Source Type: research

Abstract 471: Transcriptional coactivator CBP regulates hTERT expression through the cooperation with Sp1/AP-2{beta} and predicts poor prognosis in human lung cancers
In this study, we identified CBP as a transcriptional coactivator that specifically binds to hTERT promoter through co-anchoring with transcriptional factors Sp1 and AP-2β and promotes hTERT expression in human lung cancer cells. Streptavidin-agarose pulldown and chromatin immunoprecipitation assays revealed the tumor-specific binding of CBP, Sp1 and AP-2β on the hTERT promoter. The colocalization and interaction between CBP and Sp1 or AP-2β in lung cancer cells were detected. High expression levels of CBP and hTERT in lung cancer cells and tissues were also detected compared to normal lung cells and adjacent normal lun...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Guo, W. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2485: Secretome signature associated with TITF1/NKX2-1-negative non-small cell lung cancer
Conclusion: Our findings suggest functional relevance of SRGN in tumor microenvironment and tumor aggressiveness in TITF1/NKX2-1-negative NSCLC. Validation study for plasma levels of CXCL1 and CXCL5 in NSCLC subjects is now on-going. Citation Format: Ayumu Taguchi, Muge Celiktas, Dhillon Dilsher, Qing Zhang, Chee-Hong Wong, Alice Chin, Adi Gazdar, Samir Hanash. Secretome signature associated with TITF1/NKX2-1-negative non-small cell lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Taguchi, A., Celiktas, M., Dilsher, D., Zhang, Q., Wong, C.-H., Chin, A., Gazdar, A., Hanash, S. Tags: Cancer Chemistry Source Type: research

Abstract 3318: Using synthetic lethal screening to identify therapeutic targets for innately platinum resistant lung cancer
Although platinum-based chemotherapy is the standard of care for most cases of advanced lung adenocarcinoma, its effectiveness is limited by the frequent incidence of innate chemoresistance. As a result, response rates rarely exceed 20%, even though cis-platinum and carboplatin are highly effective in other settings such as small cell lung, ovarian and testicular cancers. We hypothesized that innate chemoresistance in lung adenocarcinoma is mediated by one or more signalling pathways dependent on the expression of a single gene, and that these pathways could ultimately be targeted therapeutically. To address this question,...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Marini, K. D., Rossello, F. J., Martelotto, L. G., Watkins, D. N. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3485: Efficient transfection of cancer cell lines using the 4D-NucleofectorTM System
In this study we used the 4D-Nucleofector™ System in combination with the 96-well Shuttle™ Add-on for optimizing transfection conditions for multiple cancer cell lines. An exemplary optimization process is depicted for the human prostate carcinoma cell line DU 145 and for the human colorectal adenocarcinoma cell line COLO 205. Optimization steps included the selection of the appropriate Nucleofector™ Solution, Nucleofector™ Program and plasmid DNA concentration. Transfection parameters were thereby optimized for a variety of adherent and non-adherent human cancer cell lines resulting in transfection efficiencies of...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Schroeder, J., Altrogge, L., Lorbach, E., Kokatam, S., Schaepermeier, S., Weigel, M., Andretta-Beu, G., Buesch, S., Grabeck, T., Krumnow, A., Spicker, S., Kallol, S., Kapoor, P., Toell, A. Tags: Molecular and Cellular Biology Source Type: research

Abstract 4455: Targeting a novel kras-integrin-linked kinase regulatory circuitry in pancreatic cancer
In this study, we have identified a novel KRAS-E2F1-ILK-hnRNP A1 regulatory circuitry that governs the expression of oncogenic KRAS. Integrin-linked kinase (ILK) is a serine/threonine kinase that mediates a diversity of cellular functions including cell survival, cell-matrix interactions, angiogenesis and also plays a role in epithelial to mesenchymal transition (EMT) in cancer cells. Dysregulation of ILK expression has been observed in several tumors including breast, ovary, melanoma, lung, prostate and pancreas and reported to be correlated with tumor progression, metastasis and chemoresistance to gemcitabine in pancreat...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Chu, P.-C., Yang, M.-C., Kulp, S. K., Chen, C.-S. Tags: Molecular and Cellular Biology Source Type: research

Abstract 5203: Long non-coding RNA H19 as a novel therapeutic target for pancreatic cancer
Long non-coding RNAs (lncRNAs), non-protein coding transcripts longer than 200 nucleotides, have been recently reported to play important roles in carcinogenesis and cancer metastasis through epigenetic regulation. In the present study, we examined the expression levels and roles of lncRNA in pancreatic cancer to elucidate whether lncRNA could be a novel candidate for pancreatic cancer therapy. First, we injected PANC-1 and PK-45H, pancreatic ductal adenocarcinoma cells into the spleens of NOD/Shi-scid, IL-2Rγnull (NOG) mice, and then established novel cell lines from liver and lung metastatic nodules. Microarray analysis...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Yoshimura, H., Matsuda, Y., Suzuki, T., Naito, Z., Ishiwata, T. Tags: Molecular and Cellular Biology Source Type: research