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Total 766 results found since Jan 2013.

ERGIC3 silencing additively enhances the growth inhibition of BFA on lung adenocarcinoma cells.
CONCLUSION: ERGIC3 silencing in combination with BFA treatment could additively inhibit lung cancer cell growth. This finding might shed a light on new adjuvant therapy for lung adenocarcinoma. PMID: 31530266 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - September 16, 2019 Category: Cancer & Oncology Authors: Zhao Q, Wu M, Zheng X, Yang L, Zhang Z, Li X, Chen J Tags: Curr Cancer Drug Targets Source Type: research

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response.
Conclusions: These data identify a previously unknown role for GSK-3 kinases in the regulation of the TopBP1/ATR/Chk1 DNA damage response pathway. The data also support the inclusion of patients with PDAC in clinical studies of 9-ING-41 alone and in combination with gemcitabine. PMID: 31533931 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - September 17, 2019 Category: Cancer & Oncology Authors: Ding L, Madamsetty VS, Kiers S, Alekhina O, Ugolkov A, Dube J, Zhang Y, Zhang JS, Wang E, Dutta SK, Schmitt DM, Giles FJ, Kozikowski AP, Mazar AP, Mukhopadhyay D, Billadeau DD Tags: Clin Cancer Res Source Type: research

Cancer ‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer
In conclusion, Wnt2 secreted by CAFs plays a key role in cancer progression and is a potential therapeutic target for CRC.
Source: Cancer Medicine - October 16, 2019 Category: Cancer & Oncology Authors: Takashi Aizawa, Hideaki Karasawa, Ryo Funayama, Matsuyuki Shirota, Takashi Suzuki, Shimpei Maeda, Hideyuki Suzuki, Akihiro Yamamura, Takeshi Naitoh, Keiko Nakayama, Michiaki Unno Tags: ORIGINAL RESEARCH Source Type: research

Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells.
CONCLUSIONS: Given that the lncRNA CCAT1 was found to be overexpressed in endometrial cancer, affected the growth of HEC-1B cells and the expression of growth regulatory genes, our data suggest CCAT1 to exert oncogenic functions in endometrial cancer and encourage further studies to examine to what extent this lncRNA might be a potential therapy target in this cancer entity. PMID: 32173521 [PubMed - as supplied by publisher]
Source: The International Journal of Biochemistry and Cell Biology - March 11, 2020 Category: Biochemistry Authors: Treeck O, Skrzypczak M, Schüler-Toprak S, Weber F, Ortmann O Tags: Int J Biochem Cell Biol Source Type: research

FAM60A promotes cisplatin resistance in lung cancer cells by activating SKP2 expression
Cisplatin is a widely used chemotherapeutic drug in lung cancer treatment. Most cancer patients eventually develop cisplatin resistance, resulting in a poor prognosis. Previously, we identified a novel marker, family with sequence similarity 60A (FAM60A), that was responsible for resistance in cisplatin-resistant human lung adenocarcinoma A549 (A549/DDP) cells. Here, we investigated the biological effects of FAM60A in A549/DDP cells and explored the underlying molecular mechanisms to understand its functional role in cisplatin resistance. Real-time quantitative PCR and western blot analysis were used to determine the expre...
Source: Anti-Cancer Drugs - August 14, 2020 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF ‑α.
In conclusion, low expression of PRKCDBP promoted cisplatin resistance in LAD by DNMT1 and TNF‑α. PMID: 32945503 [PubMed - as supplied by publisher]
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Deregulation of a Cis-Acting lncRNA in Non-small Cell Lung Cancer May Control HMGA1 Expression
ConclusionOur results suggest that HMGA1-lnc is a novel cis-acting lncRNA that negatively regulates HMGA1 gene expression in lung cells. Further characterization of this regulatory mechanism may advance our understanding of the maintenance of lung cancer phenotypes and uncover a novel therapeutic intervention point for tumors driven by HMGA1.
Source: Frontiers in Genetics - January 11, 2021 Category: Genetics & Stem Cells Source Type: research

Cancers, Vol. 13, Pages 827: Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and its Target APOBEC3G and Thereby Pancreatic Cancer Progression
We examined whether sulforaphane interferes with lncRNA signaling and analyzed five PDAC and two nonmalignant cell lines, patient tissues (n = 30), and online patient data (n = 350). RT-qPCR, Western blotting, MTT, colony formation, transwell and wound healing assays; gene array analysis; bioinformatics; in situ hybridization; immunohistochemistry and xenotransplantation were used. Sulforaphane regulated the expression of all of five examined lncRNAs, but basal expression, biological function and inhibition of H19 were of highest significance. H19 siRNA prevented colony formation, migration, invasion and Smad2 phosphorylat...
Source: Cancers - February 16, 2021 Category: Cancer & Oncology Authors: Yiqiao Luo Bin Yan Li Liu Libo Yin Huihui Ji Xuefeng An Jury Gladkich Zhimin Qi Carolina De La Torre Ingrid Herr Tags: Article Source Type: research

LncRNA NFYC-AS1 promotes the development of lung adenocarcinomas through autophagy, apoptosis, and MET/c-Myc oncogenic proteins
CONCLUSIONS: In summary, the above results suggest that NFYC-AS1 may promote the proliferation of LAUD through autophagy and apoptosis.PMID:34926665 | PMC:PMC8640918 | DOI:10.21037/atm-21-4995
Source: Cancer Control - December 20, 2021 Category: Cancer & Oncology Authors: Ye Song Jike Du Pinglan Lu Qingfeng Zou Shaoting Zeng Meiyuan Liu Xiaoye Hu Wen Ma Hanhong Lin Xiaoyan Liu Feiyu Niu Source Type: research

Thymidine phosphorylase induction by ionizing radiation antagonizes 5-fluorouracil resistance in human ductal pancreatic adenocarcinoma
Radiat Environ Biophys. 2022 Jan 27. doi: 10.1007/s00411-022-00962-w. Online ahead of print.ABSTRACTChemoresistance in pancreatic ductal adenocarcinoma (PDAC) frequently contributes to failure of systemic therapy. While the radiosensitizing properties of 5-fluorouracil (FU) are well known, it is unknown whether ionizing radiation (IR) sensitizes towards FU cytotoxicity. Here, we hypothesize that upregulation of thymidine phosphorylase (TP) by IR reverses FU chemoresistance in PDAC cells. The FU resistant variant of the human PDAC cell line AsPC-1 (FU-R) was used to determine the sensitizing effects of IR. Proliferation rat...
Source: Radiation and Environmental Biophysics - January 27, 2022 Category: Physics Authors: Lucas D Lee Ioannis Pozios Verena Liu Silke B Nachbichler Dirk B öhmer Carsten Kamphues Katharina Beyer Christiane J Bruns Martin E Kreis Hendrik Seeliger Source Type: research

Investigation of the effects of the toll-like receptor 4 pathway on immune checkpoint vista in pancreatic cancer
In this study, we investigated the relation of TLR4 and downstream pathways with immune-check point VISTA in pancreatic cancer proliferation. We initially collected pancreatic cancer-related datasets using the GEPIA2 and UALCAN databases. Based on this data obtained the effect of various concentrations and incubation times of naloxone were used on PANC-1 cells proliferation. A combination of naloxone and VISTA-siRNA were applied, and the effect of both naloxone and combinedtreatment on TLR4, Interleukin 1 receptor associated kinase 4 (IRAK4) and VISTA gene expression were analyzed in pancreatic cancer cells. As a result of...
Source: Investigational New Drugs - February 3, 2022 Category: Drugs & Pharmacology Source Type: research

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