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Nutrition: Flavonoids
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Total 121 results found since Jan 2013.
Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope
Phytother Res. 2023 Sep 5. doi: 10.1002/ptr.7975. Online ahead of print.ABSTRACTFlavonoids are natural polyphenolic compounds considered safe, pleiotropic, and readily available molecules. It is widely distributed in various food products such as fruits and vegetables and beverages such as green tea, wine, and coca-based products. Many studies have reported the anticancer potential of flavonoids against different types of cancers, including solid tumors. The chemopreventive effect of flavonoids is attributed to various mechanisms, including modulation of autophagy, induction of cell cycle arrest, apoptosis, and antioxidant...
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Mukta Gupta Javed Ahmad Javed Ahamad Snehashis Kundu Archit Goel Awanish Mishra Source Type: research
Naringin modulates microglial polarization through the PPAR- γ/NF-κB signaling pathway to promote functional recovery following spinal cord injury
CONCLUSION: Nar promotes functional recovery by regulating microglial polarization and inhibiting the inflammatory response in SCI, and its mechanism may be related to the PPAR-γ/NF-κB signaling pathway activity.PMID:37661010 | DOI:10.1016/j.brainres.2023.148563
Source: Brain Research - September 3, 2023 Category: Neurology Authors: Bo Li Xi-Fan Mei Source Type: research
Don ’ t Get Dragged Down By “ Zombie Cells ”
Did you watch any of the zombie shows that were all over the airways a few years back?
I confess my sons and I really got into the program The Walking Dead. Watching the cast of characters try to survive in a world overrun by dead zombies was a fun way to spend some time together and wrap up a Sunday night.
Typically, when I think of the word “zombie,” I’m thinking of science fact, not fiction…
Zombie cells are known scientifically as senescent cells. These are dysfunctional cells that have stopped dividing and are nearing the end of their natural lives.
Zombie cells are too sick and damaged to carry out the...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Source Type: news
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't n...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice
Curr Res Pharmacol Drug Discov. 2023 Jul 11;5:100161. doi: 10.1016/j.crphar.2023.100161. eCollection 2023.ABSTRACTChronic stress is a risk factor for depression and is characterized by elevated levels of brain monoamine oxidase A (MAOA). Mounting evidence has shown that MAOA is a biochemical link between stress and depression. Apigenin (API), a natural flavonoid, as demonstrated in vitro inhibitory effect on MAOA, is suggestive of antidepressant-like activity. However, the in vivo inhibitory effect of API on MAOA and how it affects depression still remain unclear. Here, we report the probable mechanisms of action of API in...
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Juliet N Olayinka Oluwole B Akawa Emmanuela K Ogbu Anthony T Eduviere Raymond I Ozolua Mahmoud Soliman Source Type: research
Neuroprotective Strategies for Stroke by Natural Products: Advances and Perspectives
Curr Neuropharmacol. 2023 Jul 17. doi: 10.2174/1570159X21666230717144752. Online ahead of print.ABSTRACTCerebral ischemic stroke is a disease with high prevalence and incidence. Its management focuses on rapid reperfusion with intravenous thrombolysis and endovascular thrombectomy. Both therapeutic strategies reduce disability, but the therapy time window is short, and the risk of bleeding is high. Natural products (NPs) have played a key role in drug discovery, especially for cancer and infectious diseases. However, they have made little progress in clinical translation and pose challenges to the treatment of stroke. Rece...
Source: Current Neuropharmacology - July 17, 2023 Category: Drugs & Pharmacology Authors: Aifen Liu Jingyan Hu Tzu-Shao Yeh Chengniu Wang Jilong Tang Xiaohong Huang Bin Chen Liexiang Huangfu Weili Yu Lei Zhang Source Type: research
Neuroprotective Effect of Quercetin and Nano-quercetin Against Cyclophosphamide-induced Oxidative Stress in the Rat Brain: Role of Nrf2/ HO-1/Keap-1 Signaling Pathway
Neurotoxicology. 2023 Jul 5:S0161-813X(23)00088-8. doi: 10.1016/j.neuro.2023.06.008. Online ahead of print.ABSTRACTQuercetin (Qu) is a powerful flavanol antioxidant that is naturally found in plants and is part of the flavonoid family. Qu has a wide range of biological properties, such as neuroprotective, anti-cancer, anti-diabetic, anti-inflammatory, and radical scavenging capabilities. However, the in vivo application of QU is limited by its poor water solubility and low bioavailability. These issues could be addressed by utilizing Qu nanoformulations. Cyclophosphamide (CP) is a potent chemotherapeutic agent that causes ...
Source: Cancer Control - July 7, 2023 Category: Cancer & Oncology Authors: Dina A AbdElrazek Marwa A Ibrahim Neven H Hassan Eman I Hassanen Khaled Y Farroh H I Abass Source Type: research
3',4'-Dihydroxyflavonol Attenuates Lipopolysaccharide-Induced Neuroinflammatory Responses of Microglial Cells by Suppressing AKT-mTOR and NF- κB Pathways
Biol Pharm Bull. 2023;46(7):914-920. doi: 10.1248/bpb.b23-00033.ABSTRACTMicroglia-related neuroinflammation contributes to the pathogenesis of a variety of neurodegenerative disorders such as Alzheimer's disease. The synthetic flavonoid, 3',4'-dihydroxyflavonol (3,3',4'-trihydroxyflavone), has been shown to protect brain or myocardial ischemia reperfusion-induced cell death and prevent the aggregation of amyloid-β protein, a process that causes progressive neurodegeneration in Alzheimer's disease. Here, we explored the anti-neuroinflammatory ability of 3',4'-dihydroxyflavonol in lipopolysaccharide (LPS)-activated MG6 micr...
Source: Biological and Pharmaceutical Bulletin - July 2, 2023 Category: Drugs & Pharmacology Authors: Tatsuhiro Akaishi Shohei Yamamoto Kazuho Abe Source Type: research
Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway
In this study, we aimed to investigate the mechanisms of Pb-induced anxiety, depression and neuroinflammation, and the neuroprotective effect of ICAB in mouse brains. We found that ICAB supplementation significantly improved behavioral abnormalities, neuroinflammation and oxidative stress induced by Pb. ICAB attenuated Pb-induced anxiety and depression behavior in mice, as indicated by decreasing the duration of immobility in tail suspension test and increasing the crossing number, rearing number and time in center in open field test. Accordingly, ICAB inhibited oxidative stress by decreasing malondialdehyde (MDA) level an...
Source: Neurotoxicology - June 29, 2023 Category: Neurology Authors: Jia-Xue Shi Chao Cheng Hai-Nan Ruan Jun Li Chan-Min Liu Source Type: research
