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Specialty: Cancer & Oncology
Condition: Stroke
Cancer: Brain Cancers
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Total 93 results found since Jan 2013.
Diagnostic accuracy of major stroke types in Chinese adults: A clinical adjudication study involving 40,000 stroke cases
Lancet Reg Health West Pac. 2022 Mar 5;21:100415. doi: 10.1016/j.lanwpc.2022.100415. eCollection 2022 Apr.ABSTRACTBACKGROUND: Widespread use of brain imaging in suspected stroke cases in Chinese adults has prompted the need for clinical adjudication studies of stroke types. We conducted a clinical adjudication study to assess the reporting and diagnostic accuracy of major stroke types.METHODS: The prospective China Kadoorie Biobank recruited >512,000 adults (mean age 52 years, 59% women) from 10 urban and rural areas in China during 2004-2008, and recorded 45,859 first-ever incident stroke cases during an 11-year follow...
Source: Cancer Control - March 14, 2022 Category: Cancer & Oncology Authors: Iain Turnbull Robert Clarke Neil Wright Yu Guo Christina Kartsonaki Pei Pei Alex Hacker Canqing Yu Simon Gilbert Ling Yang Jinyi Zhou Sam Sansome Jun Lv Liming Li Zhengming Chen Yiping Chen Source Type: research
Rm-02 * long-term survival in glioblastoma patients following stroke: a non-consecutive case series
CONCLUSION: Long-term survival with glioblastoma is uncommon, particularly following recurrence, and particularly in the absence of ongoing treatment. Though stroke is in general a poor prognostic factor for patients with glioblastoma, here we highlight the possibility that the acute vascular disruption that results from strokes can occasionally arrest tumor growth. Although endovascular embolization is unlikely to ever be considered an appropriate treatment for glioblastoma, these findings support the notion that vascular disrupting agents and endovascular therapies that are limited to a single vascular territory may have...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Hu, J., Phuphanich, S., Fan, X., Rudnick, J., Prasad, R. Tags: RESISTANCE/RECURRENCE MECHANISMS Source Type: research
Stroke of luck: Scientists discover target for stroke therapy in blood-brain barrier
(Tokyo University of Science) The blood-brain barrier prevents immune cells from circulating freely in the brain, and the breakdown of its function is a major cause of post-stroke inflammation. Now, for the first time, researchers have identified how a toxic stroke byproduct, acrolein, could activate the barrier-degrading enzyme proheparanase (proHPSE). The research group has discovered that proHPSE degrades the glycocalyx within the post-stroke brain's blood vessels, providing hope for new and effective therapeutics against post-stroke inflammation.
Source: EurekAlert! - Cancer - February 22, 2021 Category: Cancer & Oncology Source Type: news
Diagnosis and Management of Stroke in Adults with Primary Brain Tumor
This article reviews the risk factors, clinical presentations, differential diagnosis, and the types of strokes frequently seen in patients with primary brain neoplasms. This includes a discussion of approaches with a review of the available literature and provides recommendations for primary and secondary prevention specific to this patient population.Recent FindingsStrokes in patients with brain tumors are often multifactorial. However, tailored approaches to stroke care are necessary to achieve optimal patient outcomes, AHA/ASA stroke guidelines provide little information on the management of stroke in cancer patients. ...
Source: Current Oncology Reports - May 11, 2022 Category: Cancer & Oncology Source Type: research
Transcranial Doppler Velocity and Brain MRI/MRA Changes in Children With Sickle Cell Anemia on Chronic Transfusions to Prevent Primary Stroke
ConclusionsFor children with SCA and abnormal TCD velocities, transfusions lower TCD velocities and help prevent stroke, but do not always result in normal velocities or protect against progression of cerebral vasculopathy. Improved adherence to transfusion goals may improve on‐treatment TCD velocities. Pediatr Blood Cancer 2013;9999:XX–XX. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - April 26, 2013 Category: Cancer & Oncology Authors: Vivien A. Sheehan, Eileen N. Hansbury, Matthew P. Smeltzer, Gail Fortner, M. Beth McCarville, Banu Aygun Tags: Research Article Source Type: research
Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00077-6. doi: 10.1016/j.brainresbull.2022.03.008. Online ahead of print.ABSTRACTIschemic stroke in rodents is usually induced by intraluminal occlusion of the middle cerebral artery (MCA) via the external carotid artery (ECA) or the common carotid artery (CCA). The latter route requires permanent CCA occlusion after ischemia, and here, we assess its effects on long-term outcomes. Transient occlusion of MCA and CCA was performed at normal body temperature. After 90minutes of ischemia, mice were randomized to permanent CCA occlusion or no occlusion (control group). Body weight, and m...
Source: Cancer Control - March 19, 2022 Category: Cancer & Oncology Authors: Zhong Yang Xuan Li Zhipeng Cao Peng Wang David S Warner Huaxin Sheng Source Type: research
Can mental practice adjunct in the recovery of motor function in the upper limbs after stroke? A systematic review and meta-analysis
CONCLUSION: Current evidence does not support the use of the mental practice to increase the recovery of the upper limb after stroke, although the evidence is conflicting for some aspects of the technique.PMID:36267434 | PMC:PMC9578308 | DOI:10.4103/bc.bc_28_22
Source: Cancer Control - October 21, 2022 Category: Cancer & Oncology Authors: Danielle Aprigio Juliana Bittencourt Maria Ramim Victor Marinho Igor Brauns Isabelle Fernandes Pedro Ribeiro Bruna Velasques Ana Catarina Alves E Silva Source Type: research
Ischemic stroke in a patient with EGFR ‐mutated non–small‐cell lung cancer after treatment with ramucirumab
This article presents the case of a non–small-cell lun g cancer patient who experienced a new ischemic stroke after treatment with ramucirumab. The findings suggest that further studies may be necessary to investigate the relationship between ramucirumab and the risk of ischemic stroke.
Source: Thoracic Cancer - October 29, 2022 Category: Cancer & Oncology Authors: Guo ‐Yu Chen,
Wen‐Chien Cheng,
Chih‐Yen Tu Tags: CASE REPORT Source Type: research
Survivors of childhood cancer have high-risk of recurrent stroke
(University of California - San Francisco) A new study from the UCSF Pediatric Brain Center shows that childhood cancer survivors suffering one stroke have double the risk of suffering a second stroke, when compared with non-cancer stroke survivors.
Source: EurekAlert! - Cancer - August 26, 2015 Category: Cancer & Oncology Source Type: news
Acute ischaemic stroke and myocardial infarction after chemotherapy with vinorelbine for non-small cell lung cancer: a case report.
We report about a 70-year-old male with metastatic non-small cell lung cancer who received vinorelbine as an outpatient. The patient presents with a cardiovascular risk profile. He was admitted to the hospital 3 days later with acute left-sided hemiplegia and hemianopia. Brain computed tomography (CT) demonstrated acute right hemispheric ischaemic stroke. Nine days after admission, the patient additionally suffered ST elevation myocardial infarction. A coronary angiogram demonstrated high grade stenosis of the right coronary artery treated with two bare-metal stents. Caution should be noted in patients who present with a c...
Source: Journal of Chemotherapy - November 18, 2015 Category: Cancer & Oncology Tags: J Chemother Source Type: research
Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke.
In conclusion, xenogenic ADMSC/ADMSC-derived exosome therapy was safe and offered the additional benefit of reducing BIZ and improving neurological function in rat AIS.
PMID: 27793019 [PubMed - as supplied by publisher]
Source: Oncotarget - October 31, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Ntox-11. recurrent episodes of stroke-like migraine attacks after radiation therapy (smart) syndrome in adults
We report two cases of multiply-recurrent SMART syndrome, one autopsy-documented. Case 1 is a 46 year old woman with an atypical meningioma treated with resection and radiation who presented sixteen months after completion of radiation with sudden onset hemiparesis and dysarthria. Brain MRI showed the typical gyriform enhancement seen in SMART syndrome. No other attributable disorders were found on extensive workup, and both symptoms and radiographic abnormalities resolved over several weeks without further therapies. Six months later she again presented with identical symptoms and MRI findings. Incomplete resolution ...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Mohler, A., Kleinschmidt-DeMasters, B. K., Damek, D. Tags: NEUROTOXICITY OF THERAPY Source Type: research
Chronic cerebral hypoperfusion and blood-brain barrier disruption in uninjured brain areas of rhesus monkeys subjected to transient ischemic stroke
J Cereb Blood Flow Metab. 2022 Feb 9:271678X221078065. doi: 10.1177/0271678X221078065. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) disruption is a pivotal pathophysiological process in ischemic stroke. Although temporal changes in BBB permeability during the acute phase have been widely studied, little is known about the chronic phase of cerebrovascular changes that may have a large impact on the long-term outcome. Therefore, this study was aimed to measure cerebral vascular abnormalities using CT perfusion in nine rhesus monkeys subjected to transient middle cerebral artery occlusion (tMCAO) for ≥1 year (MCA...
Source: Cancer Control - February 9, 2022 Category: Cancer & Oncology Authors: Yingqian Zhang Bangcheng Zhao Qi Lai Qinxi Li Xun Tang Yinbing Zhang Zhixiang Pan Qiang Gao Zhihui Zhong Source Type: research
Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration
The objectives of this study were to (1) determine the effect of MMP-12 suppression by shRNA-mediated gene silencing on neurological/functional recovery, (2) establish the optimal timing of MMP-12shRNA treatment that provides maximum therapeutic benefit, (3) compare the effectiveness of acute versus chronic MMP-12 suppression, and (4) evaluate potential sex-related differences in treatment outcomes. Young male and female Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion and reperfusion. Cohorts of rats were administered either MMP-12shRNA or scrambled shRNA sequence (control) expressing plasm...
Source: Cancer Control - October 21, 2022 Category: Cancer & Oncology Authors: Siva Reddy Challa Koteswara Rao Nalamolu Casimir A Fornal Billy C Wang Ryan C Martin Elsa A Olson Ammar L Ujjainwala David M Pinson Jeffrey D Klopfenstein Krishna Kumar Veeravalli Source Type: research
