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Condition: Ischemic Stroke
Cancer: Brain Cancers
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Total 832 results found since Jan 2013.
Acute ischemic stroke secondary to ventriculoperitoneal shunt dysfunction in a child with Moyamoya syndrome
CONCLUSION: Children who receive RT for brain tumor, particularly if the circle of Willis region is involved, require close surveillance for the development of vasculopathy and consequent stroke. This surveillance must be even tighter if the patient has been treated with ventricular shunt for the possible synergistic interaction between the two causes on reducing cerebral perfusion and increasing the risk of acute ischemic events.PMID:35928308 | PMC:PMC9345112 | DOI:10.25259/SNI_434_2022
Source: Surgical Neurology International - August 5, 2022 Category: Neurosurgery Authors: Francesca Vitulli Pietro Spennato Domenico Cicala Giuseppe Mirone Maria Rosaria Scala Giuseppe Cinalli Source Type: research
Characterization of Astrocytes in the Minocycline-Administered Mouse Photothrombotic Ischemic Stroke Model
In this study, we used a mouse photothrombotic ischemic stroke model to examine the characteristics of astrocytes after the administration of minocycline during ischemic stroke. Minocycline increased astrocyte reactivity and affected the localization of astrocytes in the penumbra region. Molecular characterization revealed that the induced expression of mRNA encoding the fatty acid binding protein 7 (FABP7) by photothrombosis was enhanced by the minocycline administration. Meanwhile, minocycline did not significantly affect the phenotype or class of astrocytes. The expression of Fabp7 mRNA was well correlated with that of ...
Source: Neurochemical Research - July 30, 2022 Category: Neuroscience Authors: Mari Kondo Haruka Okazaki Kei Nakayama Hirofumi Hohjoh Kimie Nakagawa Eri Segi-Nishida Hiroshi Hasegawa Source Type: research
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Drug Deliv. 2022 Dec;29(1):2469-2480. doi: 10.1080/10717544.2022.2104405.ABSTRACTIschemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents loaded in nanocarriers to be delivered by noninvasive means (i.e. via intranasal route) became a popular approach. In the current study, melatonin (MEL) was loaded in lipidic nanocapsules (LNCs) prepared using the phase inversion method, and characterized in terms of size, polydispersity, zeta potential, in vitro drug release...
Source: Drug Delivery - July 27, 2022 Category: Drugs & Pharmacology Authors: Eman A Bseiso Sarah A AbdEl-Aal Maha Nasr Omaima A Sammour Nabaweya A Abd El Gawad Source Type: research
E-152 Neurointervention in the pediatric population: 18-years experience from a single center
ConclusionsAt out institution, multidisciplinary interaction allowed the treatment of a wide variety of cerebrovascular diseases in the pediatric population. Pediatric patients carry high complication risks due to frequent presence of systemic conditions, but joined experience from pediatric neurology, neurosurgery and neurointervention departments allow their treatment with optimal planning and results.Abstract E-152 Table 1Intracranial aneurysms Variable Value Age at diagnosis, mean (SD) or median (IQR) 16 (16–19) Male:Female 12:10 Associated conditions•Moya moya•Connective tissue disorder•Von Wille...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Donnelly, B., Monteiro, A., Recker, M., Khawar, W., Waqas, M., Cappuzzo, J., Reynolds, R., Siddiqui, A., Levy, E. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
E-164 Recurrent strokes as the initial presentation of colorectal adenocarcinoma
ConclusionCryptogenic strokes in patients with cancer are cardioembolic manifestations of cancer-mediated hypercoagulability such as NBTE, which consists of sterile, platelet-fibrin vegetations on cardiac valves. The mechanism of thromboembolism in patients with cancer is based on the interaction between tumor cells and leukocytes, which creates a thrombogenic vascular lining and induces the release of substances that activate the coagulation cascade. The diagnosis of NBTE should depend on the distribution of occluded vessels, identification of thrombus, and exclusion of other possible causes such as infective endocarditis...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Babici, D., Phillip Johansen, P., Rodriguez-Hernandez, A., Sommerville, S., Snelling, B., Miller, T. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
Neuroprotective, Anti-inflammatory Effect of Furanochrome, Visnagin Against Middle Cerebral Ischemia-Induced Rat Model
In this study, the anti-ischemic effect of a furanochrome visnagin was assessed in in vivo rat model. Middle cerebral ischemic/reperfusion was induced in healthy male Sprague Dawley rats and treated with different concentrations of visnagin. The neuroprotective effect of visnagin against cerebral ischemia-induced rats was assessed by analyzing the neurological score, brain edema, infract volume, and Evans blue leakage. The anti-inflammatory property of visnagin was assessed by quantifying proinflammatory cytokines in serum and brain tissues of cerebral ischemia-induced rats. Prostaglandin E-2, COX-2, and NFκ-β were estim...
Source: Applied Biochemistry and Biotechnology - July 12, 2022 Category: Biochemistry Authors: Qiangyuan Tian Hua Yin Jisen Li Jinggong Jiang Binbin Ren Junhui Liu Source Type: research
Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
In conclusion, this systematic review informs on several potential risk factors and predictors for VTE in people with ischemic stroke. To improve risk stratification and guide development of risk prediction models, further confirmation is needed, as there were few high-quality studies on each factor.PMID:35815351 | DOI:10.1111/jth.15813
Source: Thrombosis and Haemostasis - July 11, 2022 Category: Hematology Authors: Birgitte G T øndel V ânia M Morelli John-Bjarne Hansen Sigrid K Braekkan Source Type: research
Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke
Curr Neuropharmacol. 2022 Jul 6. doi: 10.2174/1570159X20666220706115957. Online ahead of print.ABSTRACTAs the first peripheral immune cells to enter the brain after ischemic stroke, neutrophils are important participants in stroke-related neuroinflammation. Neutrophils are quickly mobilized from the periphery in response to a stroke episode and cross the blood-brain barrier to reach the ischemic brain parenchyma. This process involves the mobilization and activation of neutrophils from peripheral immune organs (including the bone marrow and spleen), their chemotaxis in the peripheral blood, and their infiltration into the ...
Source: Current Neuropharmacology - July 7, 2022 Category: Drugs & Pharmacology Authors: Meizhen Xie Yulei Hao Liangshu Feng Tian Wang Mengyue Yao Hui Li Di Ma Jiachun Feng Source Type: research
