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E-051 acute ischemic stroke due to tumorigenic embolism treated with mechanical thrombectomy
ConclusionIn acute stroke secondary to malignant tumorigenic embolism, mechanical thrombectomy might be a safe and effective treatment option.DisclosuresB. Bell: None. A. Saad: None. K. Layton: None. S. Shamim: None. G. Snipes: None. K. Hesselrode: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Bell, B., Saad, A., Layton, K., Shamim, S., Snipes, G., Hesselrode, K. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy
In conclusion, our results reveal the important contribution of FUS aggregates in promoting astrocyte activation in stroke pathology independent of its transcriptional regulation activity. We thus propose that aggregation of FUS is an important pathological process in ischemic stroke and targeting FUS aggregates might be of unique therapeutic value in the development of future treatment strategies for ischemic stroke.PMID:35718207 | DOI:10.1016/j.expneurol.2022.114144
Source: Experimental Neurology - June 19, 2022 Category: Neurology Authors: Shusheng Wu Yuye Yin Longfei Du Source Type: research

Acute Ischemic Stroke Due to Undifferentiated Sarcoma: A Case Report and Literature Review.
Authors: Fukami Y, Yamaguchi K, Miyasaki A, Negoro M Abstract Tumor emboli due to a sarcoma are usually confirmed by an autopsy or operative findings. A sarcoma embolus in an acute stroke patient is rare. We herein report a 37-year-old man with acute stroke caused by internal carotid artery occlusion who underwent embolectomy. A histopathological analysis of an embolus obtained with a mechanical retriever device was diagnosed as undifferentiated sarcoma. This is the first case of extracardiac sarcoma extraction via mechanical retrieval performed during intervention for acute ischemic stroke. A histopathologic evalu...
Source: Internal Medicine - August 29, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Biological Plausibility of a Link Between Arterial Ischemic Stroke and Infection with Varicella-Zoster Virus or Herpes Simplex Virus.
Abstract There are now 9 human herpesviruses; the increase from 8 to 9 was caused by a recent decision to split human herpesvirus (HHV) strains 6A and 6B into distinct species. The 9 species are subdivided into three subfamilies, called alpha: herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV); beta: cytomegalovirus (CMV), HHV6A, HHV6B and HHV7; gamma: Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (sometimes called HHV8). These same herpesviruses have evolved with humankind around the world since the great migration of modern humans across the Mandeb Strait out of Afri...
Source: Circulation - January 26, 2016 Category: Cardiology Authors: Grose C Tags: Circulation Source Type: research

Investigation into the potential mechanism and molecular targets of Fufang Xueshuantong capsule for the treatment of ischemic stroke based on network pharmacology and molecular docking
Fufang Xueshuantong (FFXST) capsule is a traditional Chinese medicine (TCM) preparation used to activate blood circulation, resolve stasis, benefit qi, and nourish yin in clinical practice. However, its potential mechanism and molecular targets after ischemic stroke (IS) have not been investigated. The aim of this research was to investigate the molecular mechanisms of FFXST in the treatment of IS based on network pharmacology and molecular docking. We used the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) to collect candidate compounds of four herbs in FFXST; disease-related diff...
Source: Frontiers in Pharmacology - September 15, 2022 Category: Drugs & Pharmacology Source Type: research

Carotid Intimal Sarcoma Presenting as Large Vessel Occlusion and Diagnosed by Embolus Histopathology: Case Report
We report the case of a patient who presented with acute embolic ischemic stroke and was found to have IS based on a histopathologic evaluation of his embolectomy specimen. Subsequent comprehensive imaging studies failed to detect a primary tumor site. Multidisciplinary interventions including a course of radiotherapy were performed. The patient died of recurrent multifocal strokes 92 days after diagnosis. Discussion Meticulous histopathologic analysis should be conducted on cerebral embolectomy specimens. Histopathology may be useful in diagnosing IS.
Source: Neurology Clinical Practice - January 19, 2023 Category: Neurology Authors: Johnson, M. D., Rogers, E. J., Khan, M. W., McMullen, P. D., Akkipeddi, S. M. K., Mattingly, T., Benesch, C. G., Bender, M. T. Tags: Clinical/Scientific Note Source Type: research

Chemoradiotherapy for Inoperable Carotid Body Leiomyosarcoma: A Case Report and Review of Literature
Vascular leiomyosarcoma is an extremely rare tumor and is associated with poor prognosis among leiomyosarcoma. Surgical resection remains the main treatment option. But outcome of definitive treatment with chemoradiotherapy in inoperable patients is not clear. Here, we report treatment and outcome of definitive chemoradiotherapy in a case of vascular leiomyosarcoma. A 64-year-old man with the initial presentation of pulsatile right neck mass was diagnosed with right carotid body leiomyosarcoma. He refused surgical intervention due to risk of carotid body injury and ischemic stroke. Successful tumor control was achieved wit...
Source: Frontiers in Oncology - February 11, 2021 Category: Cancer & Oncology Source Type: research

A case report of an ischaemic stroke, caused by a primary cardiac intimal sarcoma
We present a case of intimal sarcoma identified without any cardiac s...
Source: BMC Cardiovascular Disorders - February 1, 2023 Category: Cardiology Authors: Joshua Lloyd, Navinee Gilliat, Graeme Porter and Francesco Pirone Tags: Case Report Source Type: research

A case of acute ischemic stroke caused by doxorubicin-induced cardiomyopathy in a patient with synovial sarcoma
Source: Acta Neurologica Belgica - March 30, 2023 Category: Neurology Source Type: research