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Total 153 results found since Jan 2013.

Time trends of incidence of age-associated diseases in the US elderly population: medicare-based analysis
Conclusion: time trends of the incidence of diseases common in the US elderly population were evaluated. The results show dramatic increase in incidence rates of melanoma, goiter, chronic renal and Alzheimer's disease in 1992–2005. Besides specifying widely recognised time trends on age-associated diseases, new information was obtained for trends of asthma, ulcer and goiter among the older adults in the USA.
Source: Age and Ageing - June 17, 2013 Category: Geriatrics Authors: Akushevich, I., Kravchenko, J., Ukraintseva, S., Arbeev, K., Yashin, A. I. Tags: Research Papers Source Type: research

UNMC Nanotechnology Protects Skin From Cancer And Early Wrinkles
Nanotechnology developed at the University of Nebraska Medical Center could strengthen things like sunscreen and anti-aging cosmetics into more potent barriers, protecting the skin from UV radiation that can cause wrinkles and skin cancer. A new startup company, ProTransit Nanotherapy, L.L.C., was founded on the innovation, and hopes to commercialize the nontoxic, biodegradable system within the next 18 months. If successful, the nanotechnology could serve as a platform that can deliver targeted treatments to a vast range of ailments, including stroke and heart disease...
Source: Health News from Medical News Today - July 10, 2013 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Preparation of well-defined ibuprofen prodrug micelles by RAFT polymerization.
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevated risk of stroke, however, can limit their use and exploration in new indications.　Here we report a facile method to prepare well-defined amphiphilic diblock copolymer NSAID prodrugs by direct reversible addition fragmentation transfer (RAFT) polymerization of the acrylamide derivative of ibuprofen (IBU), a widely used NSAID. The synthesis and self-as...
Source: Biomacromolecules - August 12, 2013 Category: Biochemistry Authors: Hasegawa U, van der Vlies AJ, Wandrey C, Hubbell JA Tags: Biomacromolecules Source Type: research

Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)
Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
Source: Annals of the Rheumatic Diseases - December 4, 2013 Category: Rheumatology Authors: Dougados, M., Soubrier, M., Antunez, A., Balint, P., Balsa, A., Buch, M. H., Casado, G., Detert, J., El-zorkany, B., Emery, P., Hajjaj-Hassouni, N., Harigai, M., Luo, S.-F., Kurucz, R., Maciel, G., Mola, E. M., Montecucco, C. M., McInnes, I., Radner, H., Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoporosis, Rheumatoid arthritis, Epidemiology, Calcium and bone Clinical and epidemiological research Source Type: research

Evaluation of Reconstructive Techniques for Anterior and Middle Skull Base Defects Following Tumor Ablation
Conclusions: Vascularized flaps provide reliable and durable reconstructive options for anterior and middle skull base defects after resection of large complex malignant neoplasms of the craniofacial region. Free flaps, such as RFFFs, ALTs, and TDAPs, are well suited for these defects. They have a low risk of complications and low donor-site morbidity and offer good functional and esthetic outcomes.
Source: Journal of Oral and Maxillofacial Surgery - July 15, 2013 Category: ENT & OMF Authors: Jayini S. Thakker, Rui Fernandes Tags: Surgical Oncology and Reconstruction Source Type: research

Small study finds that 3 years after prostate cancer treatment, men may report high quality of life and functioning
Commentary on: Jakobsson L, Persson L, Lundqvist P. Daily life and life quality 3 years following prostate cancer treatment. BMC Nurs 2013;12:11. Implications for practice and research The male patients in this study reported high levels of quality of life, with high ratings for overall physical functioning and health. They appeared to adjust to the diminished sexual function. Nurses can use these outcomes and the results from other studies to inform patients. Nurses should understand that each individual will have a different prediagnosis level of and valuation of sexual activity/function. Further multicentred large studi...
Source: Evidence-Based Nursing - March 14, 2014 Category: Nursing Authors: Albaugh, J. Tags: Adult nursing, Stroke, Prostate cancer, Urological cancer, Sexual and gender disorders, Prostate, Health education Source Type: research

Concomitant Low Dose Doxorubicin Treatment and Exercise.
Abstract Cardiotoxicity is a common side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3x10(5)) were injected subcutaneously into the scruff of 6-8 week old male C57BL/6 mice (n= 48). A 4 mg/kg cumulative dose of DOX (IP) was administered over 2 weeks (2 mg/kg, 1 day/week) and exercise (EX) consisted of treadmill walking (10 m/min, 45 min/d, 5 days/week, 2 weeks). Four experi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 9, 2014 Category: Physiology Authors: Sturgeon K, Schadler K, Muthukumaran G, Ding D, Bajulaiye A, Thomas NJ, Ferrari VA, Ryeom S, Libonati JR Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Concomitant low-dose doxorubicin treatment and exercise
Cardiotoxicity is a side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low-intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3 x 105) were injected subcutaneously into the scruff of 6- to 8-wk-old male C57BL/6 mice (n = 48). A 4 mg/kg cumulative dose of DOX was administered over 2 wk, and exercise (EX) consisted of treadmill walking (10 m/min, 45 min/day, 5 days/wk, 2 wk). Four experimental groups were tested: 1) sedentary (SED) + vehicl...
Source: AJP: Regulatory, Integrative and Comparative Physiology - September 15, 2014 Category: Physiology Authors: Sturgeon, K., Schadler, K., Muthukumaran, G., Ding, D., Bajulaiye, A., Thomas, N. J., Ferrari, V., Ryeom, S., Libonati, J. R. Tags: Cardiovascular and Renal Integration Source Type: research

Talon noir: paring can eliminate the need for a biopsy
Introduction Talon noir (black heel or calcaneal petechiae) is a benign condition that appears as an asymmetric brown-black epidermal macule on the heel or elsewhere on the plantar foot. Punctate papillary dermal haemorrhages extend into the subcorneal space following shearing forces in an area of recurrent or sudden trauma.1 These lesions can mimic melanoma and haemorrhagic viral warts, especially in cases where there is no history of trauma. If the diagnosis of talon noir is considered, simple bedside tests can obviate the need for a biopsy to exclude malignant melanoma or unnecessary treatment for a presumed viral wart....
Source: Postgraduate Medical Journal - November 26, 2014 Category: Journals (General) Authors: Googe, A. B., Schulmeier, J. S., Jackson, A. R., Brodell, R. T. Tags: General practice / family medicine, Drugs: cardiovascular system, Pain (neurology), Stroke, Skin cancer, Screening (oncology), Radiology, Dermatology, Surgical diagnostic tests, General surgery, Epidemiology Images in medicine Source Type: research

Clinical Outcomes of Metastatic Intra-cerebral Hemorrhage and Role of Acute Radiotherapy (P3.077)
CONCLUSIONS: Early recognition of metastatic disease as the etiology of ICH is important, particularly when it is the presenting manifestation. Despite the overall poor prognosis of metastatic cancer, early radiotherapy may increase survival and offer quality of life in selected group of patients. A larger case series is needed.Disclosure: Dr. Afzal has nothing to disclose. Dr. Mendoza has nothing to disclose. Dr. Latorre has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Afzal, U., Mendoza, M., Latorre, J. Tags: Cerebrovascular Disease and Interventional Neurology: Hemorrhagic and Ischemic Stroke Source Type: research

Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases
The present review aims to ascertain whether different infertility etiologies share particular genes and/or molecular pathways with other pathologies and are associated with distinct and particular risks of later-life morbidity and mortality. In order to reach this aim, we use two different sources of information: (1) a public web server named DiseaseConnect (http://disease-connect.org) focused on the analysis of common genes and molecular mechanisms shared by diseases by integrating comprehensive omics and literature data; and (2) a literature search directed to find clinical comorbid relationships of infertility etiologi...
Source: Reproductive Biology and Endocrinology - April 15, 2015 Category: Endocrinology Authors: Juan TarínMiguel García-PérezToshio HamataniAntonio Cano Source Type: research

Things I Wish I'd Known When I Was Younger
I am 64 years old. There, I admit it. Women don't always want to admit their age, but there is one really good thing about seeing the decades roll by: I finally appreciate that "women's health" means different things at different times. For this year's National Women's Health Week, we're focusing on what steps women can take at different ages and stages to live a healthier life. And now that I am older, I'd like to share some of my thoughts on things I wish someone had told me when I was younger. In my 20s Fall in love with working out. Sometimes when you're young, you think you don't need to exercise. You can run, jum...
Source: Healthy Living - The Huffington Post - May 11, 2015 Category: Consumer Health News Source Type: news

Tildrakizumab (MK‐3222), an Anti‐ IL‐23p19 Monoclonal Antibody, Improves Psoriasis in a Phase 2b Randomized Placebo‐ Controlled Trial
ConclusionsTildrakizumab demonstrated superior efficacy vs. placebo that was maintained up to 52 weeks of treatment and for an additional 20 weeks after cessation of study therapy. Tildrakizumab was generally safe and well tolerated. These results suggest that IL‐23p19 is a key target for suppressing psoriasis. ClinicalTrials Registry # NCT01225731This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - June 1, 2015 Category: Dermatology Authors: K. Papp, D. Thaçi, K. Reich, E. Riedl, R.G. Langley, J.G. Krueger, A.B. Gottlieb, H. Nakagawa, E.P. Bowman, A. Mehta, Q. Li, Y. Zhou, R. Shames Tags: Original Article Source Type: research

Tildrakizumab (MK-3222), an Anti- IL-23p19 Monoclonal Antibody, Improves Psoriasis in a Phase 2b Randomized Placebo- Controlled Trial.
CONCLUSIONS: Tildrakizumab demonstrated superior efficacy vs. placebo that was maintained up to 52 weeks of treatment and for an additional 20 weeks after cessation of study therapy. Tildrakizumab was generally safe and well tolerated. These results suggest that IL-23p19 is a key target for suppressing psoriasis. ClinicalTrials Registry # NCT01225731 This article is protected by copyright. All rights reserved. PMID: 26042589 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - June 3, 2015 Category: Dermatology Authors: Papp K, Thaçi D, Reich K, Riedl E, Langley RG, Krueger JG, Gottlieb AB, Nakagawa H, Bowman EP, Mehta A, Li Q, Zhou Y, Shames R Tags: Br J Dermatol Source Type: research

Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study.
Abstract High levels of arsenic exposure have been associated with increases in cardiovascular disease risk. However, studies of arsenic's effects at lower exposure levels are limited and few prospective studies exist in the United States using long-term arsenic exposure biomarkers. We conducted a prospective analysis of the association between toenail arsenic and cardiovascular disease mortality using longitudinal data collected on 3939 participants in the New Hampshire Skin Cancer Study. Using Cox proportional hazard models adjusted for potential confounders, we estimated hazard ratios and 95% confidence interva...
Source: Toxicology and Applied Pharmacology - June 2, 2015 Category: Toxicology Authors: Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR Tags: Toxicol Appl Pharmacol Source Type: research