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Specialty: Gastroenterology
Cancer: Skin Cancer

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Total 72 results found since Jan 2013.

Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma < em > via < /em > the PI3K/AKT pathway
CONCLUSION: Our study suggests for the first time that DDX51 promotes cancer cell proliferation by regulating the PI3K/AKT pathway; thus, DDX51 might be a therapeutic target for ESCC.PMID:35125830 | PMC:PMC8790558 | DOI:10.3748/wjg.v28.i4.464
Source: World Journal of Gastroenterology - February 7, 2022 Category: Gastroenterology Authors: Dong-Xin Hu Qi-Feng Sun Lin Xu Hong-Da Lu Fan Zhang Zhen-Miao Li Ming-Yan Zhang Source Type: research

LncRNA CASC9 promotes proliferation, migration and apoptosis of hepatocellular carcinoma cells by down-regulating miR-424-5p.
CONCLUSION: CASC9 reduced proliferation, invasion and migration and induced apoptosis in HCC cells by inhibiting miR-424-5p. LncRNAs, long non-coding RNAs; HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein; CASC9, cancer sensitivity 9; ESCC, esophageal squamous cell carcinoma; qRT-PCR, quantitative reverse transcription polymerase chain reaction; ATCC, American Type Culture Collection; DMEM, Dulbecco's Modified Eagle Medium; CCK-8, cell counting kit-8; RIPA, radio-immunoprecipitation assay; SDS-PAGE, sodium dodecylsulphate polyacrylamide gel electrophoresis; PVDF, polyvinylidene fluoride; GAPDH, glyceraldehyde-3-phosph...
Source: Annals of Hepatology - December 23, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Role of cIAP1 and XIAP in Apoptosis Induced by Tumor Necrosis Factor Alpha in Esophageal Squamous Cell Carcinoma Cells
ConclusioncIAP1 and XIAP play an essential role in the resistance of ESCC cells against apoptosis.
Source: Digestive Diseases and Sciences - January 2, 2017 Category: Gastroenterology Source Type: research

Long noncoding RNA, tissue differentiation ‐inducing nonprotein coding RNA is upregulated and promotes development of esophageal squamous cell carcinoma
Summary Esophageal squamous cell carcinoma (ESCC) is one of the major causes of cancer death worldwide, especially in Eastern Asia. Due to the poor prognosis, it is necessary to further dissect the underlying mechanisms and explore therapeutic targets of ESCC. Recently, studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. Increasing evidence indicates that some lncRNAs are widely involved in the development and progression of ESCC, such as HOTAIR, SPRY4‐IT1 and POU3F3. An emerging lncRNA, tissue differentiation‐inducing nonprotein coding RNA (TINC...
Source: Diseases of the Esophagus - February 1, 2016 Category: Gastroenterology Authors: Y. Xu, M. Qiu, Y. Chen, J. Wang, W. Xia, Q. Mao, L. Yang, M. Li, F. Jiang, L. Xu, R. Yin Tags: Original Article Source Type: research

Long noncoding RNA, tissue differentiation‐inducing nonprotein coding RNA is upregulated and promotes development of esophageal squamous cell carcinoma
Summary Esophageal squamous cell carcinoma (ESCC) is one of the major causes of cancer death worldwide, especially in Eastern Asia. Due to the poor prognosis, it is necessary to further dissect the underlying mechanisms and explore therapeutic targets of ESCC. Recently, studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. Increasing evidence indicates that some lncRNAs are widely involved in the development and progression of ESCC, such as HOTAIR, SPRY4‐IT1 and POU3F3. An emerging lncRNA, tissue differentiation‐inducing nonprotein coding RNA (TINC...
Source: Diseases of the Esophagus - January 1, 2016 Category: Gastroenterology Authors: Y. Xu, M. Qiu, Y. Chen, J. Wang, W. Xia, Q. Mao, L. Yang, M. Li, F. Jiang, L. Xu, R. Yin Tags: Original Article Source Type: research

Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer.
CONCLUSION: γ-catenin is a tumor suppressor in ESCC and may serve as a prognostic marker. Dysregulated expression of γ-catenin may play important roles in ESCC progression. PMID: 24914344 [PubMed - in process]
Source: World Journal of Gastroenterology - May 21, 2014 Category: Gastroenterology Authors: Fang WK, Liao LD, Gu W, Chen B, Wu ZY, Wu JY, Shen J, Xu LY, Li EM Tags: World J Gastroenterol Source Type: research

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy.
CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. PMID: 24764668 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 21, 2014 Category: Gastroenterology Authors: Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, Nomura F Tags: World J Gastroenterol Source Type: research

Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues
Apurinic/apyrimidinic endonuclease-1 (APE-1) is a key enzyme responsible for DNA base excision repair and is also a multifunctional protein such as redox effector for several transcriptional factors. Our study was designed to investigate APE-1 expression and to study its interaction with cyclooxygenase (COX)-2 expression and VEGF production in the esophageal cancer. The expression of APE-1, COX-2, monocyte chemoattractant protein (MCP)-1, CC-chemokine receptor (CCR)2, and VEGF were evaluated by immunohistochemistry in 65 human esophageal squamous cell carcinoma (ESCC) tissues. Real-time PCR and Western blotting were perfor...
Source: AJP: Gastrointestinal and Liver Physiology - February 1, 2014 Category: Gastroenterology Authors: Nagoya, H., Futagami, S., Shimpuku, M., Tatsuguchi, A., Wakabayashi, T., Yamawaki, H., Kodaka, Y., Kawagoe, T., Watarai, Y., Makino, H., Miyashita, M., Tsuchiya, S., Crowe, S. E., Sakamoto, C. Tags: CALL FOR PAPERS Source Type: research

Apurinic/Apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.
Conclusion APE-1 is overexpressed and associated with COX-2 expression and VEGF production in esophageal cancer tissues. PMID: 24284961 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - November 27, 2013 Category: Gastroenterology Authors: Nagoya H, Futagami S, Shimpuku M, Tatsuguchi A, Wakabayashi T, Yamawaki H, Kodaka Y, Kawagoe T, Watarai Y, Makino H, Miyashita M, Tsuchiya S, Crowe SE, Sakamoto C Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research