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Radio-immunotherapy by < sup > 188 < /sup > Re-antiCD20 and stable silencing of IGF-IR in Raji cells, new insight in treatment of lymphoma
Gene. 2023 Jul 19:147638. doi: 10.1016/j.gene.2023.147638. Online ahead of print.ABSTRACTHematologic malignancies such as Non-Hodgkin's lymphoma (NHL), remain a serious threat to human health due to their heterogeneity and complexity. The inherent genetic heterogeneity of NHL B-cells, as well as the instability of lymphoma cancer cells, results in drug resistance in lymphoma, posing a fundamental challenge to NHL treatment. Burkitt lymphoma (including Raji cell line) is a rare and highly aggressive form of B-cell NHL. Since overexpression of the insulin-like growth factor-1 receptor (IGF-1R) playing a prominent role in the...
Source: Gene - July 21, 2023 Category: Genetics & Stem Cells Authors: Leila Nasehi Baharak Abdolhossein Zadeh Hossein Rahimi Mohammad Hossein Ghahremani Source Type: research

Clinical applications of gene therapy for rare diseases: A review
Int J Exp Pathol. 2023 May 13. doi: 10.1111/iep.12478. Online ahead of print.ABSTRACTRare diseases collectively exact a high toll on society due to their sheer number and overall prevalence. Their heterogeneity, diversity, and nature pose daunting clinical challenges for both management and treatment. In this review, we discuss recent advances in clinical applications of gene therapy for rare diseases, focusing on a variety of viral and non-viral strategies. The use of adeno-associated virus (AAV) vectors is discussed in the context of Luxturna, licenced for the treatment of RPE65 deficiency in the retinal epithelium. Imly...
Source: Herpes - May 13, 2023 Category: Infectious Diseases Authors: Ioannis Papaioannou James S Owen Rafael J Y áñez-Muñoz Source Type: research

Current advancements in self-assembling nanocarriers-based siRNA delivery for cancer therapy
Colloids Surf B Biointerfaces. 2022 Nov 2;221:113002. doi: 10.1016/j.colsurfb.2022.113002. Online ahead of print.ABSTRACTDifferent therapeutic practices for treating cancers have significantly evolved to compensate and/or overcome the failures in conventional methodologies. The demonstrated potentiality in completely inhibiting the tumors and in preventing cancer relapse has made nucleic acids therapy (NAT)/gene therapy as an attractive practice. This has been made possible because NAT-based cancer treatments are highly focused on the fundamental mechanisms - i.e., silencing the expression of oncogenic genes responsible fo...
Source: Colloids and Surfaces - November 12, 2022 Category: Biotechnology Authors: Ganeshlenin Kandasamy Dipak Maity Source Type: research

SOCS1 Gene Therapy for Head and Neck Cancers: An Experimental Study
CONCLUSION: Overexpression of SOCS1 has a potent antitumor effect on HNSCC, suggesting the potential for clinical use. The varying effectiveness among cancer cells by over expression of SOCS1 may contribute to efficacy of SOCS 1 gene therapy for clinical use.PMID:35790291 | DOI:10.21873/anticanres.15823
Source: Cell Research - July 5, 2022 Category: Cytology Authors: Taihei Kajiyama Satoshi Serada Minoru Fujimoto Tomoharu Ohkawara Masahiro Komori Masamitsu Hyodo Tetsuji Naka Source Type: research

RAISING is a high-performance method for identifying random transgene integration sites
Commun Biol. 2022 Jun 2;5(1):535. doi: 10.1038/s42003-022-03467-w.ABSTRACTBoth natural viral infections and therapeutic interventions using viral vectors pose significant risks of malignant transformation. Monitoring for clonal expansion of infected cells is important for detecting cancer. Here we developed a novel method of tracking clonality via the detection of transgene integration sites. RAISING (Rapid Amplification of Integration Sites without Interference by Genomic DNA contamination) is a sensitive, inexpensive alternative to established methods. Its compatibility with Sanger sequencing combined with our CLOVA (Clo...
Source: Cancer Control - June 2, 2022 Category: Cancer & Oncology Authors: Yusaku Wada Tomoo Sato Hiroo Hasegawa Takahiro Matsudaira Naganori Nao Ariella L G Coler-Reilly Tomohiko Tasaka Shunsuke Yamauchi Tomohiro Okagawa Haruka Momose Michikazu Tanio Madoka Kuramitsu Daisuke Sasaki Nariyoshi Matsumoto Naoko Yagishita Junji Yama Source Type: research

Fight Aging! Newsletter, February 14th 2022
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process. Naked Mole Rats Exhibit Minimal Cardiac Aging https://www.fightaging.org/archives/2022/02/naked...
Source: Fight Aging! - February 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reactivation of γ-globin expression using a minicircle DNA system to treat β-thalassemia
Gene. 2022 Feb 7:146289. doi: 10.1016/j.gene.2022.146289. Online ahead of print.ABSTRACTReactivation of fetal hemoglobin by editing the B-cell lymphoma/leukemia 11A (BCL11A) erythroid enhancer is an effective gene therapy for β-thalassemia. Using the CRISPR/Cas9 system, fetal γ-globin expression can be robustly reactivated to mitigate the clinical course of β-thalassemia. In our study, we found that the transfection efficiencies of CD34+ hematopoietic stem/progenitor cells (HSPCs) were significantly and negatively correlated with the length of plasmids and greatly affected by the linearization of plasmids. Furthermore, ...
Source: Gene - February 10, 2022 Category: Genetics & Stem Cells Authors: Shuang-Ping Ma Xu-Xia Gao Guo-Qiang Zhou Hao-Kun Zhang Jing-Min Yang Wen-Juan Wang Xian-Min Song Hong-Yan Chen Da-Ru Lu Source Type: research

Fight Aging! Newsletter, September 6th 2021
In conclusion, patients over 90 years of age had an overall low prevalence of fractures and relative preservation of bone health, suggesting a preserved bone molecular profile in these individuals. Epigenetic factors and activity levels might also have favorably affected bone health. The low percentage of osteoporosis and fractures likely reduced the morbidity and mortality in this population, potentially contributing to their overall longevity. Building a Therapy for Aging Based on SIRT6 Upregulation https://www.fightaging.org/archives/2021/08/building-a-therapy-for-aging-based-on-sirt6-upregulation/ Ge...
Source: Fight Aging! - September 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

New Treatment for Relapsed or Refractory Large B-cell lymphoma
Am J Nurs. 2021 Jun 1;121(6):21-22. doi: 10.1097/01.NAJ.0000753644.07326.f6.ABSTRACTLisocabtagene maraleucel (Breyanzi), a personalized cell-based gene therapy, has been approved to treat adults with various relapsed or refractory large B-cell lymphomas.PMID:34009160 | DOI:10.1097/01.NAJ.0000753644.07326.f6
Source: The American Journal of Nursing - May 19, 2021 Category: Nursing Authors: Diane S Aschenbrenner Source Type: research

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